Principal Investigator

David Topham, Ph.D. University of Rochester work Box 609 601 Elmwood Ave Rochester NY 14642 office: KMRB 3-9631 p 585-273-1403 f 585-273-2452

Mathematical and Computational Modeling of Influenza Immunity

Simulation of the effect of target lung epithelial cell number (Ep) on influenza virus (V) replication.

Mathematical and computational methods are being employed to model aspects of the immune response to influenza. In a collaboration among investigators in the Center for Biodefense Immune Modeling (CBIM, Hulin Wu PI). The goal of the CBIM is to develop comprehensive, quantitative models of the immune response to influenza A infection, a potential bioterror agent and emerging pathogen, and create computational tools to explore such scenarios in silico. The Topham Lab has also partnered with scientists at IBM in a project to develop molecular dynamic simulations of human HLA molecules in complex with influenza peptide antigens. This is a collaborative project through the new UR Health Science Center for Computational Innovation (HSCCI. Topham, Executive Director), IBM, and URMC investigators. The goal is to accurately predict 3-dimensional structures of peptide-HLA complexes and assess effects on the T cell repertoire.

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