Principal Investigator

Thomas A. Gasiewicz, Ph.D. University of Rochester work Box EHSC 601 Elmwood Ave Rochester NY 14642 office: MC 4-5702 p (585) 275-7723

Role of AhR in Hematopoiesis and Hematopoietic Disease

Ah Receptor (AhR) Presence and Acitivity is Essential For Hematoppoietic Stem Cell (HSC) Regulation and Function.

Our laboratory has demonstrated that persistent activation of AhR by dioxin results in altered numbers and functions of hematopoietic stem cells (HSCs) in mouse bone marrow. Combined with data showing that a lack of AhR function also results in altered HSC characteristics and hematopoietic diseases (such as leukemia), our findings strongly suggest that a normal role for AhR may be to regulate HSC’s. The lab is currently studying this connection as well as how changing AhR regulation and function leads to hematopoietic diseases.

Ongoing Questions for the Lab:

  • Are HSC's direct targets of AhR activation?
  • How does loss of AhR affect HSC function?
  • What is the molecular basis for altered HSC characteristics and function following AhR dysregulation
  • Is the down regulation of the AhR necessary for the normal proliferation of HSC's?
  • How does the AhR regulate normal HSC function?
  • Does altered AhR regulation have a role in leukemia and lymphoma? Does the AhR have a similar role in other stem cell populations?
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