Principal Investigator

Steven A. Goldman, M.D., Ph.D. University of Rochester work Box 645 Rochester NY p 585-275-9550

The Goldman Lab Genomics Database

To view and compare gene lists or search for a gene, please visit our genomics database.

Contact

Goldman Lab University of Rochester work 601 Elmwood Ave Rochester NY 14642 p 585-276-4595 f 585-276-2298

Affiliations

Welcome to the Division of Cell and Gene Therapy

In the division of Cell and Gene Therapy, within the Center for Translational Neuromedicine (CTN), our goal is to understand the regulatory control of stem and progenitor cells of the human CNS, and to utilize that knowledge to design new approaches for treating neurological diseases, primarily using cell and gene therapy. We have two principal focuses, one on the glial disorders potentially modifiable through a better understanding of glial progenitor cell biology, and the other on those neuronal disorders potentially treatable through the induction of neuronal addition or replacement from mobilized endogenous stem and progenitor cells. Our disease targets are those attributable to dysfunction or loss of single cell types; for instance, demyelinating disease is studied as a potential target for oligodendrocyte progenitor cell delivery, while Huntington’s disease is studied as a potential beneficiary of medium spiny neuronal replacement from endogenous stem cells. Conversely, gliomas and gliomagenesis are studied from the standpoint of dysregulated signaling by endogenous glial progenitors.

In regards to the glial disorders, we are targeting an expansive category that includes not only multiple sclerosis and vascular demyelination, but also the hereditary leukodystrophies and storage disorders, as well as glial neoplasms and even neuropsychiatric disorders. In particular, we have a strong focus on using cell transplantation technologies for the treatment of the glial and myelin disorders.

At the same time, we continue to study adult neurogenesis, in both songbird and mammalian models, with the goal of mobilizing endogenous progenitors in those neurodegenerative disorders potentially ameliorated by neuronal replacement. Our intent is to induce neuronal production in adults as a means of structural repair of damaged or diseased neural circuits, with the induction of medium spiny neurogenesis for cell replacement in Huntington’s Disease being prototypic.

To these various ends, we have developed a broad set of stem and progenitor cell focused technologies that have permitted us to make substantial progress on many fronts.

Major Lines of Investigation

Recent Publications

    1. Wang Z
    2. Zhu B
    3. Zhang M
    4. Parikh H
    5. Jia J
    6. Chung CC
    7. Sampson JN
    8. Hoskins JW
    9. Hutchinson A
    10. Burdette L
    11. Ibrahim A
    12. Hautman C
    13. Raj PS
    14. Abnet CC
    15. Adjei AA
    16. Ahlbom A
    17. Albanes D
    18. Allen NE
    19. Ambrosone CB
    20. Aldrich M
    21. Amiano P
    22. Amos C
    23. Andersson U
    24. Andriole G
    25. Andrulis IL
    26. Arici C
    27. Arslan AA
    28. Austin MA
    29. Baris D
    30. Barkauskas DA
    31. Bassig BA
    32. Beane Freeman LE
    33. Berg CD
    34. Berndt SI
    35. Bertazzi PA
    36. Biritwum RB
    37. Black A
    38. Blot W
    39. Boeing H
    40. Boffetta P
    41. Bolton K
    42. Boutron-Ruault MC
    43. Bracci PM
    44. Brennan P
    45. Brinton LA
    46. Brotzman M
    47. Bueno-de-Mesquita HB
    48. Buring JE
    49. Butler MA
    50. Cai Q
    51. Cancel-Tassin G
    52. Canzian F
    53. Cao G
    54. Caporaso NE
    55. Carrato A
    56. Carreon T
    57. Carta A
    58. Chang GC
    59. Chang IS
    60. Chang-Claude J
    61. Che X
    62. Chen CJ
    63. Chen CY
    64. Chen CH
    65. Chen C
    66. Chen KY
    67. Chen YM
    68. Chokkalingam AP
    69. Chu LW
    70. Clavel-Chapelon F
    71. Colditz GA
    72. Colt JS
    73. Conti D
    74. Cook MB
    75. Cortessis VK
    76. Crawford ED
    77. Cussenot O
    78. Davis FG
    79. De Vivo I
    80. Deng X
    81. Ding T
    82. Dinney CP
    83. Di Stefano AL
    84. Diver WR
    85. Duell EJ
    86. Elena JW
    87. Fan JH
    88. Feigelson HS
    89. Feychting M
    90. Figueroa JD
    91. Flanagan AM
    92. Fraumeni JF
    93. Freedman ND
    94. Fridley BL
    95. Fuchs CS
    96. Gago-Dominguez M
    97. Gallinger S
    98. Gao YT
    99. Gapstur SM
    100. Garcia-Closas M
    101. Garcia-Closas R
    102. Gastier-Foster JM
    103. Gaziano JM
    104. Gerhard DS
    105. Giffen CA
    106. Giles GG
    107. Gillanders EM
    108. Giovannucci EL
    109. Goggins M
    110. Gokgoz N
    111. Goldstein AM
    112. Gonzalez C
    113. Gorlick R
    114. Greene MH
    115. Gross M
    116. Grossman HB
    117. Grubb R
    118. Gu J
    119. Guan P
    120. Haiman CA
    121. Hallmans G
    122. Hankinson SE
    123. Harris CC
    124. Hartge P
    125. Hattinger C
    126. Hayes RB
    127. He Q
    128. Helman L
    129. Henderson BE
    130. Henriksson R
    131. Hoffman-Bolton J
    132. Hohensee C
    133. Holly EA
    134. Hong YC
    135. Hoover RN
    136. Hosgood HD
    137. Hsiao CF
    138. Hsing AW
    139. Hsiung CA
    140. Hu N
    141. Hu W
    142. Hu Z
    143. Huang MS
    144. Hunter DJ
    145. Inskip PD
    146. Ito H
    147. Jacobs EJ
    148. Jacobs KB
    149. Jenab M
    150. Ji BT
    151. Johansen C
    152. Johansson M
    153. Johnson A
    154. Kaaks R
    155. Kamat AM
    156. Kamineni A
    157. Karagas M
    158. Khanna C
    159. Khaw KT
    160. Kim C
    161. Kim IS
    162. Kim YH
    163. Kim YC
    164. Kim YT
    165. Kang CH
    166. Jung YJ
    167. Kitahara CM
    168. Klein AP
    169. Klein R
    170. Kogevinas M
    171. Koh WP
    172. Kohno T
    173. Kolonel LN
    174. Kooperberg C
    175. Kratz CP
    176. Krogh V
    177. Kunitoh H
    178. Kurtz RC
    179. Kurucu N
    180. Lan Q
    181. Lathrop M
    182. Lau CC
    183. Lecanda F
    184. Lee KM
    185. Lee MP
    186. Le Marchand L
    187. Lerner SP
    188. Li D
    189. Liao LM
    190. Lim WY
    191. Lin D
    192. Lin J
    193. Lindstrom S
    194. Linet MS
    195. Lissowska J
    196. Liu J
    197. Ljungberg B
    198. Lloreta J
    199. Lu D
    200. Ma J
    201. Malats N
    202. Mannisto S
    203. Marina N
    204. Mastrangelo G
    205. Matsuo K
    206. McGlynn KA
    207. McKean-Cowdin R
    208. McNeill LH
    209. McWilliams RR
    210. Melin BS
    211. Meltzer PS
    212. Mensah JE
    213. Miao X
    214. Michaud DS
    215. Mondul AM
    216. Moore LE
    217. Muir K
    218. Niwa S
    219. Olson SH
    220. Orr N
    221. Panico S
    222. Park JY
    223. Patel AV
    224. Patino-Garcia A
    225. Pavanello S
    226. Peeters PH
    227. Peplonska B
    228. Peters U
    229. Petersen GM
    230. Picci P
    231. Pike MC
    232. Porru S
    233. Prescott J
    234. Pu X
    235. Purdue MP
    236. Qiao YL
    237. Rajaraman P
    238. Riboli E
    239. Risch HA
    240. Rodabough RJ
    241. Rothman N
    242. Ruder AM
    243. Ryu JS
    244. Sanson M
    245. Schned A
    246. Schumacher FR
    247. Schwartz AG
    248. Schwartz KL
    249. Schwenn M
    250. Scotlandi K
    251. Seow A
    252. Serra C
    253. Serra M
    254. Sesso HD
    255. Severi G
    256. Shen H
    257. Shen M
    258. Shete S
    259. Shiraishi K
    260. Shu XO
    261. Siddiq A
    262. Sierrasesumaga L
    263. Sierri S
    264. Sihoe AD
    265. Silverman DT
    266. Simon M
    267. Southey MC
    268. Spector L
    269. Spitz M
    270. Stampfer M
    271. Stattin P
    272. Stern MC
    273. Stevens VL
    274. Stolzenberg-Solomon RZ
    275. Stram DO
    276. Strom SS
    277. Su WC
    278. Sund M
    279. Sung SW
    280. Swerdlow A
    281. Tan W
    282. Tanaka H
    283. Tang W
    284. Tang ZZ
    285. Tardon A
    286. Tay E
    287. Taylor PR
    288. Tettey Y
    289. Thomas DM
    290. Tirabosco R
    291. Tjonneland A
    292. Tobias GS
    293. Toro JR
    294. Travis RC
    295. Trichopoulos D
    296. Troisi R
    297. Truelove A
    298. Tsai YH
    299. Tucker MA
    300. Tumino R
    301. Van Den Berg D
    302. Van Den Eeden SK
    303. Vermeulen R
    304. Vineis P
    305. Visvanathan K
    306. Vogel U
    307. Wang C
    308. Wang C
    309. Wang J
    310. Wang SS
    311. Weiderpass E
    312. Weinstein SJ
    313. Wentzensen N
    314. Wheeler W
    315. White E
    316. Wiencke JK
    317. Wolk A
    318. Wolpin BM
    319. Wong MP
    320. Wrensch M
    321. Wu C
    322. Wu T
    323. Wu X
    324. Wu YL
    325. Wunder JS
    326. Xiang YB
    327. Xu J
    328. Yang HP
    329. Yang PC
    330. Yatabe Y
    331. Ye Y
    332. Yeboah ED
    333. Yin Z
    334. Ying C
    335. Yu CJ
    336. Yu K
    337. Yuan JM
    338. Zanetti KA
    339. Zeleniuch-Jacquotte A
    340. Zheng W
    341. Zhou B
    342. Mirabello L
    343. Savage SA
    344. Kraft P
    345. Chanock SJ
    346. Yeager M
    347. Landi MT
    348. Shi J
    349. Chatterjee N
    350. Amundadottir LT
    (2014 Jul 15). Imputation and subset based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Hum Mol Genet. In press.
    1. Chandler KB
    2. Brnakova Z
    3. Sanda M
    4. Wang S
    5. Stalnaker SH
    6. Bridger R
    7. Zhao P
    8. Wells L
    9. Edwards NJ
    10. Goldman R
    (2014 Jul 03). Site-specific glycan microheterogeneity of inter-alpha-trypsin inhibitor heavy chain h4. J Proteome Res. 13, 3314-29.
    1. Goldman SA
    2. Osorio J
    (2014 Apr 01). So many progenitors, so little myelin. Nat Neurosci. 17, 483-5.