Welcome to the Maggirwar Lab
Research Focus - Platelets, HIV and Inflammation
Despite the use of antiretroviral therapies, a majority of HIV infected individuals still develop HIV-associated neurocognitive disorders (HAND), indicating that host inflammatory mediators, in addition to viral proteins, may be contributing to these disorders. Our lab is interested in determining the mechanisms by which host factors are contributing to these disorders, with a large focus on alterations to the blood brain barrier (BBB) during infection that allow infiltration of the CNS by activated leukocytes. Specifically, we are focusing on the dysregulation of signaling events within platelets, leading to pro-inflammatory complications, as well as other cell types that are involved in regulation of the BBB such as pericytes, astrocytes, and endothelial cells that make up the neurovascular unit.
- Dual targeting of the thioredoxin and glutathione antioxidant systems in malignant B cells: A novel synergistic therapeutic approach. Exp Hematol. 43, 89-99. (2015 Feb 01).
- Investigating the role of ankyrin-rich membrane spanning protein in human immunodeficiency virus type-1 Tat-induced microglia activation. J Neurovirol. In press. (2015 Jan 31).
- Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation. J Immunol. 192, 4674-84. (2014 May 15).