Welcome to the Mapstone Lab
Dr. Mapstone studies cognitive function in health and disease. His research addresses mechanisms of cognitive impairment in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease and ways to detect these cognitive changes as early in the course of the disease as possible.
His current work in this area focuses on blood based and electrophysiological biomarker discovery for Alzheimer’s and Parkinson’s diseases. His research also addresses cognitive effects of treatment for neurological diseases such as deep brain stimulation, stem cell therapy and cognitive training. Dr. Mapstone is a clinical neuropsychologist and his research is integrated into his clinical work.
- Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study.Alzheimers Dement. 11, 600-607.e1. (2015 Jun 01).
- Memory timeline: Brain ERP C250 (not P300) is an early biomarker of short-term storage.Brain Res. 1604, 74-83. (2015 Apr 16).
- Fatigability disrupts cognitive processes' regulation of inflammatory reactivity in old age.Am J Geriatr Psychiatry. 22, 1544-54. (2014 Dec 01).