Principal Investigator

Marc W. Halterman, M.D., Ph.D. University of Rochester work 601 Elmwood Ave Rochester NY 14642 office: MC 1-9609 p 585-273-1335

Contact

Marc Halterman Lab University of Rochester work KMRB 1-9828 601 Elmwood Ave Rochester NY 14642

Affiliations

Molecular-Based Therapies for Ischemic Brain Injury

We are interested in finding new approaches to treat ischemic brain injury. In particular, our lab focuses on signaling nodes in transcriptional networks that regulate neuron survival and are amenable to small molecule regulation. Putative targets identified through genomic and proteomic-based screens are first validated in vivo and studied further using primary neuronal cultures, neurospheres and related in vitro assays. To manipulate gene function we use several complementary approaches including knockout mouse models, viral mediated gene regulation, site-directed mutagenesis and pharmacological inhibition. Ultimately, our goal is to identify novel therapeutic targets and treatments for disorders in which ischemia is a central component.

Current Research Projects