Molecular-Based Therapies for Ischemic Brain Injury
We are interested in finding new approaches to treat ischemic brain injury. In particular, our lab focuses on signaling nodes in transcriptional networks that regulate neuron survival and are amenable to small molecule regulation. Putative targets identified through genomic and proteomic-based screens are first validated in vivo and studied further using primary neuronal cultures, neurospheres and related in vitro assays. To manipulate gene function we use several complementary approaches including knockout mouse models, viral mediated gene regulation, site-directed mutagenesis and pharmacological inhibition. Ultimately, our goal is to identify novel therapeutic targets and treatments for disorders in which ischemia is a central component.
Current Research Projects
- De novo mutations in SIK1 cause a spectrum of developmental epilepsies.Am J Hum Genet. 96, 682-90. (2015 Apr 02).
- Provider impressions of the use of a mobile crowdsourcing app in medical practice.Health Informatics J. (2014 Aug 28).
- Crowdsourcing medical expertise in near real time.J Hosp Med. 9, 451-6. (2014 Jul 01).