Principal Investigator

Catherine E. Ovitt, Ph.D. University of Rochester work Box 611 Rochester NY p (585) 275-2920 f (585) 276-0190

Specification and Functional Regulation in Mucous Secreting Glands

Lineage tracing has demonstrated that Ascl3-expressing progenitor cells are precursors of mucous-secreting glands

One project is focused on the factors required for the specification of mucous acinar cells. A complementary investigation is identifying changes in saliva secretions resulting from molecular alterations in the mucous cells. The development of interventions to restore gland secretory function first requires a basic understanding of their molecular physiology. The characterization of transporter regulation and functional interactions in both salivary glands and the mucous-secreting glands of the olfactory epithelium is ongoing. Specific interactions within ion transport protein complexes are being explored through proteomic analysis. Lineage tracing has demonstrated that Ascl3-expressing progenitor cells are precursors of mucous-secreting glands. Ascl3 activity is thereby linked to regulation of the molecular program required for mucous cell identity. Additional components of this program are being explored.

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