Welcome to the Thakar Lab
Immune response to infections and vaccination depends on several factors including age, immunogenicity of the antigens, host genotype and host’s immune history.
The research focus of our lab is to delineate the effects of these factors using bioinformatics, systems biology and dynamic modeling tools. We typically integrate different datasets including gene expression, serum cytokine levels and known information about signaling and metabolic pathways.
Current Research Projects
- Boolean modeling: a logic-based dynamic approach for understanding signaling and regulatory networks and for making useful predictions. Wiley Interdiscip Rev Syst Biol Med. 6, 353-69. (2014 Sep 30).
- Immune markers associated with host susceptibility to infection with West Nile virus. Viral Immunol. 27, 39-47. (2014 Mar 01).
- Overcoming NS1-mediated immune antagonism involves both interferon-dependent and independent mechanisms. J Interferon Cytokine Res. 33, 700-8. (2013 Nov 01).