Expression of GPR56 (green) leads to the formation of a
fishnet structure of TG2 (red) in melanoma. Blue: nuclei.
The Xu laboratory investigates the mechanism of metastasis, the spread of cancer cells from their original loci to other parts of the body. It is the major cause of death in cancer patients, but exactly how it occurs is not clear. Metastasis involves multiple levels of interactions between migrating tumor cells and their microenvironment. Understanding these interactions will greatly enhance our knowledge on metastasis and lead to a better treatment of cancer. A major focus of the laboratory is thus to dissect these interactions by studying the functions of cell surface molecules during tumor spread. Knockout mice, mouse cancer models, as well as various biochemical and bioinformatics tools are used in the laboratory.
Current Research Projects
The Xu lab is happy to accept rotation students at this time. Please contact Dr. Xu for more information.
- New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Ann N Y Acad Sci. 1333, 43-64. (2014 Dec 01).
- GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2. Cancer Res. 74, 1022-31. (2014 Feb 15).
- ERBB3 is required for metastasis formation of melanoma cells. Oncogenesis. 3, e110. (2014 Jan 01).