The NCBI BioSystems database is now available to the public at: www.ncbi.nlm.nih.gov/biosystems/ .
The database can be searched directly or accessed via links from databases such as Entrez Gene, Protein, PubChem, Compound, and more. The BioSystems database page footer contains a link to the Help Desk (firstname.lastname@example.org), where questions can be sent.
A biosystem or biological system is a group of molecules that interact in a biological system. One type of biosystem is a biological pathway, which can consist of interacting genes, proteins, and small molecules. Another type of biosystem is a disease, which can involve components such as genes, biomarkers, and drugs.
A number of databases, such as KEGG and BioCyc, provide diagrams showing the components and products of biological pathways along with corresponding annotations and links to literature. The NCBI BioSystems Database was developed as a collaborative and complementary project to (1) serve as a centralized repository of data; (2) connect the biosystem records with associated literature, molecular, and chemical data throughout the Entrez system; and (3) facilitate computation on biosystems data.