Please click on the name of a lab to learn more about that lab, their research, and the people who work there.
- Bambara Lab Our group began in 1977 with a research interest in the mechanisms of chromosomal DNA replication. We defined the biochemical functions of proteins in the human replication system. The proteins in this complex display unique mechanisms of protein-DNA interaction.
- Dewhurst Lab Current research interests in my laboratory include (a) Host Adaptation by emerging Influenza viruses, (b) Role of the virus polymerase HIV Vaccine Development, and (c) NeuroAIDS Research: Cerebrovascular effects of Methamphetamine and Novel Therapeutic Approaches.
- Dunman Lab Our laboratory uses S. aureus and A. baumannii as model organisms to study bacterial pathogenesis and develop novel strategies for the therapeutic intervention of bacterial infections. That work has revealed that most bacterial virulence factors are post-transcriptionally regulated in a manner that involves the modulation of their mRNA turnover.
- Dziejman Lab In order to understanding the scope of molecular mechanisms responsible for TTSS mediated disease, we are working to (a) understand the role of the ToxR paralogs and ToxR itself in T3SS related gene expression, (b) identify in vitro conditions that promote expression of the T3SS genes, and (c) identify effector proteins that are required during infection to provide functions critical for colonization and disease.
- Elliott Lab The goal of our lab is to understand the signaling pathways that regulate how phagocytes locate and engulf apoptotic cells and how this process impacts the immune system in normal and disease states.
- Fowell Lab We are interested in the functional fate of Tregs at sites of inflammation, particularly in the context of autoimmune diabetes.
- Gill Lab Our research interests are centered around microbial pathogens and the impact of human microbial flora on human health and disease. The current focus is on (a) virulence determinants of Staphylococcus aureus and (b) relationship of the oral microbial community and oral cancer.
- Kim Lab (Minsoo) Unlike cells within solid tissues, circulating lymphocytes and other leukocytes continuously migrate and relocate during the course of immune reactions. A subset of integrins (LFA-1, Mac-1, and VLA-4) are expressed on immune cells and play a major role in regulating recruitment of immuno-competent cells to normal or damaged and infected tissues. Under a wide range of pathologic conditions such as autoimmune disease, chronic inflammation, and transplantation rejection, integrin activations are mis-regulated resulting in abnormal leukocyte trafficking, and direct damage to the vasculature and the underlying host tissue. Understanding how T cells and neutrophils home to and migrate within tissues is a major focus of our research.
- Maggirwar Lab We like to know how HIV recruits host cells to initiate inflammatory processes in infected individuals by focusing on effects of platelets on blood-brain barrier integrity.
- Martinez-Sobrido Lab Evasion of the innate immune response by viruses.
- Mosmann Lab We are using multicolor flow cytometry and Spot assays to detect the simultaneous expression of six or more cytokines by individual human or mouse T cells, to resolve the contributions of partial differentiation, stochastic variation and environmental effects to the spectrum of cytokines produced by individual cells.
- Robert Lab The overall goal of our research is to understand the co-evolutionary aspects of selected molecules (e.g., heat shock proteins [hsps], hsp-receptors [CD91], NK cell receptors [KIR, FcRs], non-classical class Ib molecules [XNCs]) and their functions in innate and adaptive immunity against tumors and viruses.
- Sant Lab The research in my laboratory centers around the molecular events that regulate MHC class II-restricted antigen presentation and CD4 T cell activation in vivo.
- Takimoto Lab Our focus is on the influenza virus RNA polymerase, and understanding how it contributes to host adaptation. We characterize the polymerase activities of avian and human strains, and identify residues and subunits of the polymerase complex important for the enhanced activity in mammalian hosts in vitro and in vivo.
- Thakar Lab Delineation the effects of age, immunogenicity of the antigens, host genotype and host’s immune history using using bioinformatics, systems biology and dynamic modeling tools.
- Topham Lab Our basic research program is focused on studying the function of adhesion molecules expressed by activated and memory T cells in the lung.
- Ward Lab The major focus of my laboratory is the study of poxvirus morphogenesis, emphasizing the intracellular envelopment process.