Faculty Lab Websites
Please click on the name of a lab to learn more about that lab, their research, and the people who work there.
Our group began in 1977 with a research interest in the mechanisms of chromosomal DNA replication. We defined the biochemical functions of proteins in the human replication system. The proteins in this complex display unique mechanisms of protein-DNA interaction.
Current research interests in my laboratory include (a) Host Adaptation by emerging Influenza viruses, (b) Role of the virus polymerase HIV Vaccine Development, and (c) NeuroAIDS Research: Cerebrovascular effects of Methamphetamine and Novel Therapeutic Approaches.
Our laboratory uses S. aureus and A. baumannii as model organisms to study bacterial pathogenesis and develop novel strategies for the therapeutic intervention of bacterial infections. That work has revealed that most bacterial virulence factors are post-transcriptionally regulated in a manner that involves the modulation of their mRNA turnover.
In order to understanding the scope of molecular mechanisms responsible for TTSS mediated disease, we are working to (a) understand the role of the ToxR paralogs and ToxR itself in T3SS related gene expression, (b) identify in vitro conditions that promote expression of the T3SS genes, and (c) identify effector proteins that are required during infection to provide functions critical for colonization and disease.
Our research interests are centered around microbial pathogens and the impact of human microbial flora on human health and disease. The current focus is on (a) virulence determinants of Staphylococcus aureus and (b) relationship of the oral microbial community and oral cancer.
Unlike cells within solid tissues, circulating lymphocytes and other leukocytes continuously migrate and relocate during the course of immune reactions. A subset of integrins (LFA-1, Mac-1, and VLA-4) are expressed on immune cells and play a major role in regulating recruitment of immuno-competent cells to normal or damaged and infected tissues. Under a wide range of pathologic conditions such as autoimmune disease, chronic inflammation, and transplantation rejection, integrin activations are mis-regulated resulting in abnormal leukocyte trafficking, and direct damage to the vasculature and the underlying host tissue.
Understanding how T cells and neutrophils home to and migrate within tissues is a major focus of our research.
We like to know how HIV recruits host cells to initiate inflammatory processes in infected individuals by focusing on effects of platelets on blood-brain barrier integrity.
Evasion of the innate immune response by viruses.
We are using multicolor flow cytometry and Spot assays to detect the simultaneous expression of six or more cytokines by individual human or mouse T cells, to resolve the contributions of partial differentiation, stochastic variation and environmental effects to the spectrum of cytokines produced by individual cells.
The overall goal of our research is to understand the co-evolutionary aspects of selected molecules (e.g., heat shock proteins [hsps], hsp-receptors [CD91], NK cell receptors [KIR, FcRs], non-classical class Ib molecules [XNCs]) and their functions in innate and adaptive immunity against tumors and viruses.
The research in my laboratory centers around the molecular events that regulate MHC class II-restricted antigen presentation and CD4 T cell activation in vivo.
Our focus is on the influenza virus RNA polymerase, and understanding how it contributes to host adaptation. We characterize the polymerase activities of avian and human strains, and identify residues and subunits of the polymerase complex important for the enhanced activity in mammalian hosts in vitro and in vivo.
Our basic research program is focused on studying the function of adhesion molecules expressed by activated and memory T cells in the lung.
The major focus of my laboratory is the study of poxvirus morphogenesis, emphasizing the intracellular envelopment process.