The Dewhurst Lab

Publications List :

By Year of Publication
Polesskaya O, Silva J, Sanfilippo C, Desrosiers T, Sun A, Shen J, Feng C, Polesskiy A, Deane R, Zlokovic B, Kasischke K, Dewhurst S. "Methamphetamine causes sustained depression in cerebral blood flow." Brain research. 2011; 1373Epub 2010 Dec 13.
Easterhoff D, Dimaio JT, Doran TM, Dewhurst S, Nilsson BL. "Enhancement of HIV-1 infectivity by simple, self-assembling modular peptides." Biophysical journal. 2011; 100(5):1325-34.
Bussey KA, Desmet EA, Mattiacio JL, Hamilton A, Bradel-Tretheway B, Bussey HE, Kim B, Dewhurst S, Takimoto T. "PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells." Journal of virology. 2011; 85(14):7020-8. Epub 2011 May 11.
Caserta MT, Dewhurst S. "Dazed and confused by HHV-6." Blood. 2011; 117(19):5016-8.
Domm W, Brooks L, Chung HL, Feng C, Bowers WJ, Watson G, McGrath JL, Dewhurst S. "Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: Association with mucoadhesion and efficient penetration of the sublingual barrier." Vaccine. 2011; Epub 2011 Jul 27.
Eggert D; Dash PK; Gorantla S; Dou H; Schifitto G; Maggirwar SB; Dewhurst S; Poluektova L; Gelbard HA; Gendelman HE. "Neuroprotective activities of CEP-1347 in models of neuroAIDS." Journal of immunology (Baltimore, Md. : 1950). 2010; 184(2):746-56. Epub 2009 Dec 04.
Desmet EA; Hollenbaugh JA; Sime PJ; Wright TW; Topham DJ; Sant AJ; Takimoto T; Dewhurst S; Maggirwar SB. "Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells." Virology. 2010; Epub 2010 Feb 24.
Love TM; Thurston SW; Keefer MC; Dewhurst S; Lee HY. "Mathematical Modeling of Ultradeep Sequencing Data Reveals That Acute CD8+ T-Lymphocyte Responses Exert Strong Selective Pressure in Simian Immunodeficiency Virus-Infected Macaques, but Still Fail to Clear Founder Epitope Sequences." Journal of virology. 2010; Epub 2010 Mar 24.
Volcy K; Dewhurst S. "Proteasome inhibitors enhance bacteriophage lambda (lambda) mediated gene transfer in mammalian cells." Virology. 2009; 384(1):77-87. Epub 2008 Dec 06.
Schifitto G; Zhong J; Gill D; Peterson DR; Gaugh MD; Zhu T; Tivarus M; Cruttenden K; Maggirwar SB; Gendelman HE; Dewhurst S; Gelbard HA. "Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment." Journal of neurovirology. 2009; 15(2):176-86.
Bimber BN; Chugh P; Giorgi EE; Kim B; Almudevar AL; Dewhurst S; O'Connor DH; Lee HY. "Nef gene evolution from a single transmitted strain in acute SIV infection." Retrovirology. 2009; 6():57. Epub 2009 Jun 08.
Kennedy EM; Hergott C; Dewhurst S; Kim B. "The mechanistic architecture of thermostable Pyrococcus furiosus family B DNA polymerase motif A and its interaction with the dNTP substrate." Biochemistry. 2009; 48(47):11161-8.
Sapinoro R; Volcy K; Rodrigo WW; Schlesinger JJ; Dewhurst S. "Fc receptor-mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells." Virology. 2008; 373(2):274-86. Epub 2008 Jan 14.
Chugh P; Bradel-Tretheway B; Monteiro-Filho CM; Planelles V; Maggirwar SB; Dewhurst S; Kim B. "Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy." Retrovirology. 2008; 5():11. Epub 2008 Jan 31.
Bradel-Tretheway BG; Kelley Z; Chakraborty-Sett S; Takimoto T; Kim B; Dewhurst S. "The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit." The Journal of general virology. 2008; 89(Pt 12):2923-32.
Norman JP; Perry SW; Reynolds HM; Kiebala M; De Mesy Bentley KL; Trejo M; Volsky DJ; Maggirwar SB; Dewhurst S; Masliah E; Gelbard HA. "HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization." PloS one. 2008; 3(11):e3731. Epub 2008 Nov 14.
Chugh P; Fan S; Planelles V; Maggirwar SB; Dewhurst S; Kim B. "Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line." Journal of molecular biology. 2007; 366(1):67-81. Epub 2006 Nov 10.
Malboeuf CM; Simon DA; Lee YE; Lankes HA; Dewhurst S; Frelinger JG; Rose RC. "Human papillomavirus-like particles mediate functional delivery of plasmid DNA to antigen presenting cells in vivo." Vaccine. 2007; 25(17):3270-6. Epub 2007 Jan 22.
Santos K; Simon DA; Conway E; Bowers WJ; Mitra S; Foster TH; Lugade A; Lord EM; Federoff HJ; Dewhurst S; Frelinger JG. "Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors." Human gene therapy. 2007; 18(2):93-105.
Sui Z; Sniderhan LF; Schifitto G; Phipps RP; Gelbard HA; Dewhurst S; Maggirwar SB. "Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia." Journal of immunology (Baltimore, Md. : 1950). 2007; 178(5):3226-36.
Zanghi CN; Sapinoro R; Bradel-Tretheway B; Dewhurst S. "A tractable method for simultaneous modifications to the head and tail of bacteriophage lambda and its application to enhancing phage-mediated gene delivery." Nucleic acids research. 2007; 35(8):e59. Epub 2007 Mar 28.
Lankes HA; Zanghi CN; Santos K; Capella C; Duke CM; Dewhurst S. "In vivo gene delivery and expression by bacteriophage lambda vectors." Journal of applied microbiology. 2007; 102(5):1337-49.
Santos K; Sanfilippo CM; Narrow WC; Casey AE; Rodriguez-Colon SM; McDermott MP; Federoff HJ; Bowers WJ; Dewhurst S. "Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging." Journal of virological methods. 2007; 145(1):37-46. Epub 2007 Jul 02.
Duke CM; Maguire CA; Keefer MC; Federoff HJ; Bowers WJ; Dewhurst S. "HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime." Vaccine. 2007; 25(42):7410-21. Epub 2007 Aug 30.
Sapinoro R; Maguire CA; Burgess A; Dewhurst S. "Enhanced transduction of dendritic cells by FcgammaRI-targeted adenovirus vectors." The journal of gene medicine. 2007; 9(12):1033-45.
Maguire CA; Sapinoro R; Girgis N; Rodriguez-Colon SM; Ramirez SH; Williams J; Dewhurst S. "Recombinant adenovirus type 5 vectors that target DC-SIGN, ChemR23 and alpha(v)beta3 integrin efficiently transduce human dendritic cells and enhance presentation of vectored antigens." Vaccine. 2006; 24(5):671-82. Epub 2005 Aug 24.
Sui Z; Fan S; Sniderhan L; Reisinger E; Litzburg A; Schifitto G; Gelbard HA; Dewhurst S; Maggirwar SB. "Inhibition of mixed lineage kinase 3 prevents HIV-1 Tat-mediated neurotoxicity and monocyte activation." Journal of immunology (Baltimore, Md. : 1950). 2006; 177(1):702-11.
Fan S; Maguire CA; Ramirez SH; Bradel-Tretheway B; Sapinoro R; Sui Z; Chakraborty-Sett S; Dewhurst S. "Valproic acid enhances gene expression from viral gene transfer vectors." Journal of virological methods. 2005; 125(1):23-33. Epub 2005 Jan 16.
Dou H; Ellison B; Bradley J; Kasiyanov A; Poluektova LY; Xiong H; Maggirwar S; Dewhurst S; Gelbard HA; Gendelman HE. "Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005; 25(37):8375-85.
Zanghi CN; Lankes HA; Bradel-Tretheway B; Wegman J; Dewhurst S. "A simple method for displaying recalcitrant proteins on the surface of bacteriophage lambda." Nucleic acids research. 2005; 33(18):e160. Epub 2005 Oct 13.
Diamond TL; Roshal M; Jamburuthugoda VK; Reynolds HM; Merriam AR; Lee KY; Balakrishnan M; Bambara RA; Planelles V; Dewhurst S; Kim B. "Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase." The Journal of biological chemistry. 2004; 279(49):51545-53. Epub 2004 Sep 26.



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