Li Lab

Selected Publications:

  1. Jeon KI, Xu X, Aizawa T, Lim JH, Jono H, Kwon DS, Abe JI, Berk BC, Li JD*, Yan C*.Vinpocetine inhibits NF-kappa B-dependent inflammation via an IKK-dependent but PDE-independent mechanism. Proc Natl Acad Sci U S A. 2010. *Corresponding authors. [Epub ahead of print]
  2. Ishinaga H, Jono H, Lim JH, Komatsu K, Xu X, Lee J, Woo CH, Xu H, Feng XH, Chen LF, Yan C, Li JD. Synergistic induction of NF-κB by TGF-β and TNF-α is mediated by PKA-dependent RelA acetylation. Biochem J. 417:583-91, 2009
  3. Ha UH, Lim JH, Kim HJ, Wu W, Jin S, Xu H, Li JD. MKP1 regulates the induction of MUC5AC Mucin by S. pneumoniae Pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem. 83:30624-31, 2008.
  4. Lim JH, Ha UH, Woo CH, Xu H, Li JD. CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia. Cell Microbiol. 10:2247-56, 2008.
  5. Koga T, Lim JH, Jono H, Ha UH, Xu H, Ishinaga H, Morino S, Xu X, Yan C, Kai H, Li JD. Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling. J Biol Chem. 283:12546-54, 2008.
  6. Lim JH, Jono H, Koga T, Woo CH, Ishinaga H, Bourne P, Xu H, Ha UH, Xu H, Li JD. Tumor Suppressor CYLD Acts as a Negative Regulator for Nontypeable Haemophilus influenza-Induced Inflammation in the Middle Ear and Lung of Mice. PLoS ONE, 2(10):e1032, 2007.
  7. Lim JH, Stirling B, Derry J, Koga T, Jono H, Woo CH, Xu H, Ha UH, Andalibi A, Feng XH, Briles DE, Zhu, H., Huang, Y, Zhang, W, Weng, X, Yin, Z, Davis RJ, Flavell RA, Li JD. Tumor Suppressor CYLD Acts as a Crucial Regulator of Acute Lung Injury in Lethal Streptococcus pneumoniae Infections. Immunity, 27(2):349-60, 2007.
  8. Ishinaga, H, Jono H, Lim JH, Kweon SM, Xu H, Ha UH, Xu H, Koga T, Yan C, Feng XH, Chen LF, & Li J.D. TGF-β Induces p65 Acetylation to Enhance Bacteria-induced NF-κB Activation. EMBO J, 26, 150-1162, 2007.
  9. Ha, U.H., Lim, J.H., Jono, H., Srivastava, A., Malley, R., Pagès, G., Jacques Pouysségur, P. & Li J.D. A Novel Role for IKKα and IKKβ in ERK-dependent Innate Mucosal Defense Response against Streptococcus pneumoniae. J. Immunol. 178, 1736-1747, 2007.
  10. Mikami F, Lim JH, Ishinaga H, Ha UH, Gu H, Koga T, Jono H, Kai H, Li JD. Li JD. TGF-β-Smad3/4 Signaling Pathway Acts as a Positive Regulator for TLR2 Induction by Bacteria via a Dual-mechanism Involving Functional Cooperation with NF-κB and MAPK Phosphatase 1-dependent Negative Cross-talk with p38 MAPK. J. Biol. Chem. 281, 22397-22408. 2006.
  11. Yoshida, H, Jono, H, Kai, H, Li JD. The tumor suppressor CYLD acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 and TRAF7. J Biol Chem. 280:41111-41121, 2005.
  12. Mikami, F, Gu, H, Jono, H, Andalibi, A, Kai, H, Li JD. Epidermal growth factor receptor acts as a negative regulator for bacterium nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via an Src-dependent p38 mitogen-activated protein kinase signaling pathway. J Biol Chem. 280:36185-94, 2005
  13. Watanabe, T., Jono, H., Han, J., Lim, D.J. and Li, J.D. Synergistic Activation of NF-κB by Nontypeable Haemophilus influenzae and Tumor Necrosis Factor-α. Proc. Natl. Acad. Sci. USA, 101:3563-8, 2004.
  14. Jono, H, Lim, JH, Chen, L.F. Xu, H, Trompouki, E., Pan, ZK, Mosialos, G, Li, J.D. NF-κB Is Essential for Induction of CYLD, the Negative Regulator of NF-κB. J. Biol. Chem. (Accelerated Publication) 279, 36171-36174, 2004.
  15. Jono, H., Xu, H., Kai, H., Lim, D.J., Kim, Y.S., Feng, X.H. and Li, J.D. TGF-β-Smad Signaling Pathway Negatively Regulates Nontypeable Haemophilus influenzae-induced MUC5AC Mucin Transcription via MAPK Phosphatase-1-dependent Inhibition of p38 MAPK. J. Biol. Chem. 278, 27811-27819, 2003.
  16. Li, J.D. Exploitation of host epithelial signaling networks by respiratory bacterial pathogens. J. Pharmacol. Sci. 91:1-7, 2003.
  17. Imasato, A., Desbois-Mouthon, C., Han, J., Kai, H., Cato, A.C., Akira, S., Li, J.D. Inhibition of p38 MAPK by glucocorticoids via induction of MAP kinase phosphatase-1 enhance nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2. J. Biol. Chem. 277:47444-47450, 2002.
  18. Jono, H., Shuto, T., Xu, H., Kai, H., Lim, D.J., Gum, J.R., Kim, Y.S., Yamaoka, S, Feng, X.H. and Li, J.D. Transforming Growth Factor-β-Smad Signaling Pathway Cooperates with NF-κB to Mediate Nontypeable Haemophilus influenzae-induced MUC2 Mucin Transcription. J. Biol. Chem. 277:45547-45557, 2002.
  19. Shuto, T., Imasato, I., Jono, H., Xu, H., Watanabe, T., Kai, H., Andalibi, A., Linthicum, F., Guan, Y.L., Han, J., Cato, A.C., Akira, S., Lim, D.J. and Li, J.D. Glucocorticoids synergistically enhance Nontypeable Haemophilus influenzae-induced Toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase. J. Biol. Chem. 277:17263-17270, 2002.
  20. Wang, B., Lim, D.J., Han, J., Kim, Y.S., Basbaum, C.B. and Li, J.D. Novel Cytoplasmic Proteins of Nontypeable Haemophilus influenzae Up-regulate Human MUC5AC Mucin Transcription via a Positive p38 MAP Kinase Pathway and a Negative PI 3-Kinase-Akt Pathway. J. Biol. Chem. 277:949-957, 2002.
  21. Shuto, T., Xu H., Wang, B, Han, J., Kai, H., Gu, X.X., Murphy, T., Lim, D.J. and Li, J.D. Activation of NF-κB by Nontypeable Haemophilus influenzae is mediated by Toll-like Receptor-2-TAK1-dependent NIK-IKKα/β-IκBα and MKK3/6-p38 MAP kinase signaling pathways. Proc. Natl. Acad. Sci. USA, 98:8774-8779, 2001.
Portrait of Jian-Dong Li, Ph. D.


Jian-Dong Li M.D., Ph.D.
Marie C. & Joseph C. Wilson Professor of
Microbiology & Immunology

GEBS Cluster Affiliation: IMV


Contact Information:

University of Rochester
School of Medicine
and Dentistry
601 Elmwood Ave, Box 672
Rochester, New York 14642

Phone: (585) 275-7195
Fax: (585) 473-9573

E-mail Dr. Li