Fall Semester 2012
                    MBI 431 - Microbial Physiology

                                          Monday & Wednesday's
                                                  2:00-3:15 PM
                             MBI Conference Room, Del Monte 2-11211


Course Description: MBI 431 is an advanced course on microbial physiology. This course provides a survey of microbial physiology with emphasis on metabolism, regulation, cell walls, membranes, ecology, and adaptation to extreme environments. The class meets twice per week for two lectures of 75 minutes each. Extensive handout materials are provided, and readings are from the current literature. Basic biochemistry is a prerequisite for this course. There is no required textbook. There will be two midterm exams and a final exam. All exams are open book. It is imperative that you take excellent notes and keep them organized. The exams are not cumulative.

Instructors:


Professor Martin Pavelka, Course Director

2-11128 DelMonte Building, Phone 5-4670
Office Hours: By appointment
Email: martin_pavelka@urmc.rochester.edu

Professor Jacqueline Abranches

G-9641 Kornberg Medical Research Building, Phone 3-1425
Office Hours: By appointment
Email: jacqueline_abranches@urmc.rochester.edu

Professor Virginia Clark (Emeritus)

Office Hours: By appointment
Email: ginny_clark@urmc.rochester.edu

Professor Michelle Dziejman

2-11135 DelMonte Building, Phone 3-4459
Office Hours: By appointment
Email: michelle_dziejman@urmc.rochester.edu

Professor Jose Lemos

G-9643 Kornberg Medical Research Building, Phone 5-1850
Office Hours: By appointment
Email: jose_lemos@urmc.rochester.edu

Professor Robert Quivey

G-9647 Kornberg Medical Research Building, Phone 5-0382
Office Hours: By appointment
Email: robert_quivey@urmc.rochester.edu

Class Schedule

Date Lecturer Lecture Topic
September 5 Martin Pavelka Cell Envelope I - Structure
September 10 Robert Quivey Bacterial cytoplasmic membrane -
structure/function
September 12 Mchelle Dziejman

Secretion pathways

 

September 17 Martin Pavelka Cell Envelope II - Synthesis
September 19 Martin Pavelka Cell Envelope III -Outer membrane
components LPS, OM, Lipoprotein
September 24 Martin Pavelka Cell Division
September 26 Robert Quivey ATP generation at the substrate level I. Carbohydrate metabolism
October 1 Robert Quivey ATP generation at the substrate level
II. Fermentation
III. TCA Cycle
October 3 Robert Quivey Electron transport
I. ATP synthesis and oxidative phosphorylation
October 8 No Class - Fall Break
October 10 Robert Quivey Electron transport
II. Anaerobic respiration
Exam 1 Pavelka/Quivey/Dziejman Time and room to be announced
October 17 Ginny Clark Regulation of transcription -
RNA polymerase
October 22 Ginny Clark Regulation of transcription - Activators and repressors
October 24 Ginny Clark Regulation of transcription – Two component systems
October 29 Ginny Clark Mechanism of translation
October 31 Ginny Clark Regulation of translation I
November 5 Ginny Clark Regulation of translation II
November 7 Ginny Clark DNA synthesis
November 12 Ginny Clark Chromosome replication and growth of populations
November 14 Ginny Clark Chemotaxis
Exam 2 Ginny Clark Time and room to be announced
November 19 Lemos, José Environmental factors
November 21 - 23 No Class - Fall Break
November 26 Lemos, José Stress II
November 28 Lemos, José Stress III
December 3 Lemos, José Biofilms and evolution
December 10 Abranches, Jacqueline Bioremediation
Exam 3 Lemos, José Time and room to be announced