Fall Semester 2012
MBI 431 - Microbial Physiology
Monday & Wednesday's
2:00-3:15 PM
MBI Conference Room, Del Monte 2-11211
Course Description: MBI 431 is an advanced course on microbial physiology. This course provides a survey of microbial physiology with emphasis on metabolism, regulation, cell walls, membranes, ecology, and adaptation to extreme environments. The class meets twice per week for two lectures of 75 minutes each. Extensive handout materials are provided, and readings are from the current literature. Basic biochemistry is a prerequisite for this course. There is no required textbook. There will be two midterm exams and a final exam. All exams are open book. It is imperative that you take excellent notes and keep them organized. The exams are not cumulative.
Instructors:
Professor Martin Pavelka, Course Director
2-11128 DelMonte Building, Phone 5-4670
Office Hours: By appointment
Email: martin_pavelka@urmc.rochester.edu
Professor Jacqueline Abranches
G-9641 Kornberg Medical Research Building, Phone 3-1425
Office Hours: By appointment
Email: jacqueline_abranches@urmc.rochester.edu
Professor Virginia Clark (Emeritus)
Office Hours: By appointment
Email: ginny_clark@urmc.rochester.edu
Professor Michelle Dziejman
2-11135 DelMonte Building, Phone 3-4459
Office Hours: By appointment
Email: michelle_dziejman@urmc.rochester.edu
Professor Jose Lemos
G-9643 Kornberg Medical Research Building, Phone 5-1850
Office Hours: By appointment
Email: jose_lemos@urmc.rochester.edu
Professor Robert Quivey
G-9647 Kornberg Medical Research Building, Phone 5-0382
Office Hours: By appointment
Email: robert_quivey@urmc.rochester.edu
Class Schedule
| Date | Lecturer | Lecture Topic |
|---|---|---|
| September 5 | Martin Pavelka | Cell Envelope I - Structure |
| September 10 | Robert Quivey | Bacterial cytoplasmic membrane - structure/function |
| September 12 | Mchelle Dziejman | Secretion pathways
|
| September 17 | Martin Pavelka | Cell Envelope II - Synthesis |
| September 19 | Martin Pavelka | Cell Envelope III -Outer membrane components LPS, OM, Lipoprotein |
| September 24 | Martin Pavelka | Cell Division |
| September 26 | Robert Quivey | ATP generation at the substrate level I. Carbohydrate metabolism |
| October 1 | Robert Quivey | ATP generation at the substrate level II. Fermentation III. TCA Cycle |
| October 3 | Robert Quivey | Electron transport I. ATP synthesis and oxidative phosphorylation |
| October 8 | No Class - Fall Break | |
| October 10 | Robert Quivey | Electron transport II. Anaerobic respiration |
| Exam 1 | Pavelka/Quivey/Dziejman | Time and room to be announced |
| October 17 | Ginny Clark | Regulation of transcription - RNA polymerase |
| October 22 | Ginny Clark | Regulation of transcription - Activators and repressors |
| October 24 | Ginny Clark | Regulation of transcription – Two component systems |
| October 29 | Ginny Clark | Mechanism of translation |
| October 31 | Ginny Clark | Regulation of translation I |
| November 5 | Ginny Clark | Regulation of translation II |
| November 7 | Ginny Clark | DNA synthesis |
| November 12 | Ginny Clark | Chromosome replication and growth of populations |
| November 14 | Ginny Clark | Chemotaxis |
| Exam 2 | Ginny Clark | Time and room to be announced |
| November 19 | Lemos, José | Environmental factors |
| November 21 - 23 | No Class - Fall Break | |
| November 26 | Lemos, José | Stress II |
| November 28 | Lemos, José | Stress III |
| December 3 | Lemos, José | Biofilms and evolution |
| December 10 | Abranches, Jacqueline | Bioremediation |
| Exam 3 | Lemos, José | Time and room to be announced |
