Anolik Lab

The Team :     Jennifer Anolik, M.D.,Ph.D., Assistant Professor of Medicine

                                Kai Bekar, Ph.D., post-doctoral fellow

                                Jennifer Hossler, laboratory technician

                                Teresa Owen, laboratory technician

                                Arumugam Palanichamy, Ph.D., post-doctoral fellow

Jennifer Anolik, M.D., Ph.D.

     Dr. Anolik's research interests include the role of B cells in the pathophysiology of systemic lupus and related autoimmune diseases, as well as the study of new immuno-modulatory treatments for lupus. As part of the research group at the University of Rochester, she has been one of the pioneers in the use of B-cell depletion for the therapy of autoimmune diseases and investigation of the effects of B cell depletion on immune function in SLE patients. Her laboratory currently focuses on the investigation of B cell tolerance and homeostatic mechanisms in early B cell development in human lupus, the effects of B cell targeted therapies on this process, and the development of a murine model of B cell depletion.

     Dr. Anolik has served as a mentor for students in her lab in the past and continues to mentor furture scientists.

Funding

     Dr. Anolik's funding sources include: the NIH, the Lupus Foundation, the Alliance for Lupus Research, the Lupus Research Institute, the Feinstein Institute, Amgen and Genetech.

Publications

     Her most recent publications include:

• Anolik JH, Friedberg J, Barnard J, Owen T, Cushing E, Campbell D, Kelly J, Looney RJ, Fisher RI, Sanz I.  B cell reconstitution after rituximab recapitulates B cell ontogeny, Clinical Immunology, in press, 2006.
• Sabahi R and Anolik JH.  B cell targeted therapy for systemic lupus erythematosus.  Drugs 66:1, 2006.
• Anolik JH, Barnard J, Owen T, Zheng B, Kemshetti S, Looney RJ, Sanz I. Recovery of peripheral blood memory B cells after rituximab treatment in SLE is delayed and lags behind lymphoid tissue memory B cell reconstitution, manuscript submitted 2006.       
• Anolik JH, Barnard J, Zheng B, Owen T, Quach T, Wei C, Miyake B, Milner E, Looney RJ, Sanz I.  Heterogeneity in human transitional B cells revealed by B cell depletion therapy, manuscript submitted 2006.
• Anolik JH, Ravikumar R, Barnard J, Owen T, Cushing E, Kemshetti S, Milner ECB, Dutcher P, Hadley J, Sanz I.  Anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid follicular dendritic cell networks, manuscript in preparation.

For a complete list of Dr. Anolik's publications, click here: Publications