Chen Lab

The Team :     Luojing Chen,Ph.D., Research Assistant Professor of Medicine

                                David Oleksyn , laboratory technician

Luojing Chen, Ph.D.

     Dr. Chen's research interests involve B cell signaling pathways. Dr. Chen’s laboratory is currently focusing on the role of PKK (a protein kinase) in lymphoma and lupus diseases.

Publications

     Her most recent publications include:

Chen, L., Haider, K.; Cariappa, A.; Rowitch, D. and Pillai, S. (2001) PKC associated kinase (PKK), a novel      membrane-associated, ankyrin repeat containing protein kinase. J.  Biol. Chem. 276(24): 21737-21744.

Moran ST, Haider K, Ow Y, Milton P, Chen L, Pillai S. (2003)  Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner. J Biol Chem. 13; 278(24): 21526-33.

Cariappa A, Chen L, Haider K, Tang M, Nebelitskiy E, Moran ST, Pillai S. (2003). A catalytically inactive form of protein kinase C-associated kinase/receptor interacting protein 4, a protein kinase C beta-associated kinase that mediates NF-kappa B activation, interferes with early B cell development. J Immunol. 15;171(4): 1875-80.

Lee SC, Bottaro A, Chen L, Insel RA. Mad1 is a transcriptional repressor of Bcl-6. Mol Immunol. (2006) 43(12): 1965-71.

Kim SW, Oleksyn DW, Rossi RM, Jordan Craig, Sanz I, Chen ,L , Zhao J. (2008). Protein kinase C-associated kinase is required for NF-{kappa}B signaling and survival in diffuse large B-cell lymphoma cells. Blood.,111(3): 1644-1653.

For a complete list of Dr. Chen's publications, click here: Publications