Research Aab Cardiovascular Research Institute (CVRI) Advancing our understanding of the basic mechanisms responsible for normal and pathological function of the cardiovascular system. Allergy/Immunology/Rheumatology The division of Allergy/Immunology/Rheumatology seeks to expand the understanding of the mechanisms that underlie musculoskeletal, autoimmune, and allergic disorders, with the goal of developing more effective and less toxic treatments. Cardiology The division of Cardiology's clinical and basic research efforts set us apart uniquely from other institutions in the region. The Center for Cardiovascular Research, part of the University of Rochester Aab Institute for the Biomedical Sciences, has brought together some of the top scientists in the field of vascular biology and cardiac diseases. This program has been instrumental in developing our basic and translational research efforts, which are truly bringing the lab bench to the bedside. Endocrinology/Metabolism The multiple research initiatives within the Endocrinology Department include Polycystic Ovarian Syndrome (PCOS), diabetes, bone disorders, and endocrine tumors, including those of the pituitary, adrenal, thyroid, and parathyroid. Gastroenterology and Hepatology The division of Gastroenterology and Hepatology is a full service academic division, which incorporates state-of-the-art technology with clinical experience, active education programs and basic and clinical research. The Gastroenterology & Hepatology clinicians provide services for patients which enables physicians to diagnose and treat many gastrointestinal conditions in new, less invasive ways. General Medicine Research initiatives of the General Medicine Division focus on areas of medical education and improvement in clinical practice and outcomes. Genetics The division of Genetics has focused on two research areas: the evaluation of genetic screening and the development of more effective anticancer agents by targeting the mutation responsible for initiating a given type of cancer. Geriatrics and Aging The division of Geriatrics and Aging continues to lead nationally in exploring medical practice patterns and their impact on patient care, as well as exploring new inpatient and outpatient programs that serve that serve the community in an efficient manner. Hematology/Oncology Our mission is not only to treat illness, but to relentlessly search for better ways to unlock the mysteries of disease. Today, we are presented with extraordinary opportunities to better understand cancers and develop breakthrough approaches to diagnosis and therapy through research. With growing programs in: Epigenetics of Cancer; Prostate/Genitourinary; Cancer Control and Epidemiology; Integrative Cancer Biology; Cancer Stem Cells and Metastasis, and; Hematologic Malignancy and Inflammation - leading to innovations that quickly bring discoveries from the bench to the bedside. The most profound impact is being felt by those who seek care. Breakthrough treatments are available faster in Rochester because of this research enterprise. Some of the nation's best medical minds are present in our community, working together to translate new scientific knowledge into tomorrow's health care, care that prevents, arrests or repairs that ravages of disease. The research engine is gaining momentum as a result of an aggressive recruitment initiative and we're seeing the benefits in additional research funding over the last several months. Hospital Medicine Alec O'Connor, MD, MPH is actively involved in clinical and educational research. His clinical research relates to various aspects of the pharmacologic management of pain, particularly neuropathic pain. His educational research addresses topics relevant to the educational value of hospital medicine experiences for medical residents. Valerie Lang, MD collaborates with him on inpatient educational issues relevant to medical students. Other members of the division collaborate with Drs. O'Connor and Lang on these projects. Infectious Diseases Research programs within the Infectious Diseases Division focus primarily on clinical virology, vaccine development, and translational research. Major areas of interest include HIV, Influenza, Respiratory Syncytial Virus, Human Papillomavirus, and Dengue. The division maintains active collaborations with investigators in the Center for Vaccine Biology and Immunology, and the Division of Immunology. Nephrology The Nephrology division has an active research enterprise, which leads to a large number of publications in excellent, peer reviewed journals. Palliative Care The research and performance component of the Palliative Care division is dedicated to advancing the science of palliative care by rigorously exploring key issues in palliative care and developing new knowledge, as well as providing a framework for clinical, educational, and financial outcome evaluations. Pulmonary/Critical Care The Division of Pulmonary and Critical Care houses a highly collaborative group of investigators engaged in clinical and basic research. Areas of interest include the health effects of air pollutions, asthma, lung immunology, nitric oxide metabolism, pulmonary fibrosis, pulmonary hypertension, respiratory viral infections and sepsis.