Mechanisms of Fracture Repair

Project Overview

Fracture healing is a complex process that involves both anabolic and catabolic responses. At the onset of fracture repair there is an initial inflammatory phase followed by the differentiation of MSCs to form a soft cartilage callus and a hard callus of woven bone, which is ultimately remodeled to generate the original cortical bone configuration. These repair processes recapitulate events during cartilage and bone formation during skeletal development. While several developmental signaling pathways have been implicated in fracture repair, we still know very little about the mechanisms that govern this process. Our lab uses an in vivo mouse model of fracture repair that combines both tissue specific “knock-out” mice and pharmacologic signaling inhibitors to better understand the molecular pathways required for normal fracture repair. Additionally, we are exploring drug treatments that promote MSC differentiation to enhance cartilage and bone formation, and thereby lead to accelerated fracture healing.

Contact

Matthew J. Hilton, Ph.D.
University of Rochester
601 Elmwood Ave., Box 665
Rochester, NY 14642
Office: SMD 1-8535
(585) 275-1335
matthew_hilton@urmc.
rochester.edu