March 10, 2014
A study involving Rochester-area seniors has yielded the first accurate blood test that can predict who is at risk for developing Alzheimer's disease. This discovery – which appears today in the journal Nature Medicine – could be the key to unlocking a new generation of treatments that seek to head off the disease before neurological damage becomes irreversible.
The biomarker – which consists of 10 specific lipids found in blood plasma – predicted with greater than 90 percent accuracy which individuals would go on to develop Alzheimer's disease or a precursor condition known as amnestic mild cognitive impairment (aMCI). The cost of the simple blood test required to detect these lipids is a fraction of other techniques and, unlike alternatives, it identifies risk early in the disease process before cognitive symptoms appears.
The ability to identify individuals who are at risk of developing Alzheimer's before the clinical manifestation of cognitive impairment has long been a Holy Grail of the neuromedicine community,said Mark Mapstone, Ph.D., a neuropsychologist with the University of Rochester School of Medicine and Dentistry and lead author of the study.
Current efforts to develop a treatment for this disease are coming up short because they are probably being used too late. Biomarkers that can allow us to intervene early in the course of the disease could be a game-changer.
February 26, 2014
Dr. Laurie Seltzer Receives Award from Journal of Pediatric Neurology for the 2013 Best Paper
The Department of Neurology is pleased and proud to announce that Dr. Laurie Seltzer, DO, Senior Instructor of Child Neurology and Epilepsy recently received an award from the editors of Pediatric Neurology for the best paper submitted in 2013 by a resident or fellow. The paper, Intraoperative EEG Predicts Postoperative Seizures in Infants with Congenital Heart Disease was published online on December 23rd 2013 and will also appear in a forthcoming print issue of the journal. The research was supported in part by a NIH Institutional Research and Academic Career Development Award (K12 NS 066098).
In this prospective, observational study, Dr. Seltzer and her co-investigators reviewed preoperative, intraoperative and postoperative EEG of 32 infants who underwent cardiac surgery. Among 17 of the children, the surgery involved deep hypothermic circulatory arrest (DHCA). Specific intraoperative EEG patterns seen in two patients undergoing prolonged DHCA were predictive of postoperative seizure within 2 days after surgery. The results suggest that the intraoperative EEG may be used not only as a tool for monitoring current status during surgery, but also as a predictive tool to determine risk for postoperative seizure in infants undergoing surgery with DHCA.
Dr. Seltzer’s accomplishment will be recognized at the 2014 Child Neurology Society Meeting in Columbus, OH.
January 28, 2014
Strong Memorial Hospital has been recognized by The Joint Commission and the American Heart Association/American Stroke Association as a Comprehensive Stroke Center. This designation, which has only been conferred on two other hospitals in New York State, places Strong among an elite group of institutions that provide highly-specialized complex stroke care.
We are proud that the Joint Commission has recognized our dedicated team of neurologists, neurosurgeons, radiologists, emergency department physicians, nurses, therapists, and staff,said neurologist Curtis Benesch, M.D., M.P.H., the medical director of the URMC Stroke and Cerebrovascular Center.
This certification is a testament to their commitment to provide the highest and most comprehensive level of stroke care to our community.
January 11, 2014
Sleep seems like a perfectly fine waste of time. Why would our bodies evolve to spend close to one-third of our lives completely out of it, when we could instead be doing something useful or exciting? Something that would, as an added bonus, be less likely to get us killed back when we were sleeping on the savanna?
Sleep is such a dangerous thing to do, when you're out in the wild,Maiken Nedergaard, a Danish biologist who has been leading research into sleep function at the University of Rochester's medical school, told me.
It has to have a basic evolutional function. Otherwise it would have been eliminated.
To read more please see the NY Times article.
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