Stroke and Cerebrovascular Research

Scope of Research: Basic Science and Clinical Research

Research goals of the Stroke Unit include 1) expanding our understanding of the mechanisms of ischemic injury to the brain; 2) improving acute ischemic stroke treatment; 3) developing more effective strategies in secondary stroke prevention; and 4) identifying cost-effective diagnostic testing and treatment.

Clinical stroke research includes:
• Active participation in clinical trials of novel treatment agents for acute stroke (Activated Protein C), endovascular interventions in acute stroke, insulin in hyperglycemic patients with intracerebral hemorrhage, and secondary prevention in patients with insulin resistance, small vessel ischemic disease or patent forament ovale.
• Identifying predictive factors for the use of transesophagel echocardiography in acute stroke
• Cost-effectiveness of carotid artery stenting vs endarterectomy
• Characterizing risk of stroke in patients with ventricular-assist devices
• Utility of telemetry in acute stroke monitoring
• Use of anti-platelet agents following carotid interventions
• Medical vs. surgical management of unruptured brain AVMs
• Genetic study of strokes in siblings

Basic science research includes:
• Investigating the response of the brain to hypoxia and how it influences cell death during stroke. In particular, we are interested in the role of Hypoxia-inducible factor 1 alpha in altering cell death during hypoxia and stroke.
• Collaborative research on putative neuroprotectants in acute ischemic stroke (Berislav Zlokovic, M.D., Ph.D.)

Curtis Benesch, M.D., M.P.H., Unit Chief
(585) 275-2530