Experimental Therapeutics Fellowship

Neurology Fellowship Programs

Important Programs and Facilities

Translational Neurology: At the Bench

Translational Research
A joint initiative of the Departments of Neurology and Neurosurgery is the URMC Center for Translational Neuromedicine. The Center includes the Divisions of Cell and Gene Therapy of the Neurology Department, and of Glial Diseases and Therapeutics of the Department of Neurosurgery, Co-directed by Steven Goldman, M.D., Ph.D. and Maiken Nedergaard, M.D., DMSc. The Center is exploiting neuronal and glial progenitor cells to develop new treatments for a variety of diseases including the neurodegenerative diseases, myelin diseases, and CNS tumors.

Translational Neurology: Bench to Bedside

Clinical Coordination and Execution
The Center for Human Experimental Therapeutics includes the headquarters for Coordinating Centers for multi-center therapeutic trials in a variety of neurological diseases. They include: Parkinson's disease, Huntington's disease, Tourette’s syndrome, dystonia, Alzheimer's disease, multiple sclerosis, epilepsy, peripheral neuropathy, Duchenne dystrophy, facioscapulohumeral dystrophy, inclusion body myositis, myotonic dystrophy, non-dystrophic myotonia, periodic paralysis, episodic ataxia, AIDS, dementia and attention deficit disorder.

Clinical Research Center
Neurology has major involvement in the NIH-funded Clinical Research Center of the University of Rochester. This facility accommodates both inpatient and outpatient clinical studies and is a part of Rochester’s Clinical and Translational Science Institute, of which Rochester is one of the first of the NIH funded sites nationally. Rochester’s CTS Building opened in May 2011 and is home to this research and to the Center for Human Experimental Therapeutics directed by Karl Kieburtz, M.D., M.P.H. Richard T. Moxley, III, M.D. is Director of the Clinical Research Center.

Translational Neurology: At the Bedside: The Neurology Department is a site for the NeuroNEXT network (principal investigator Robert Holloway). In addition, the Rochester Center for Clinical Human Experimental Therapeutics is home to the research pharmacy for NeuroNEXT.

Movement Disorders
Movement and Inherited Neurologic Disorders (MIND): working in concert with The Center for Human Experimental Therapeutics (CHET), the MIND Unit trains fellows in the clinical and experimental evaluation of movement disorders. Fellows are also trained in deep brain stimulation management, working together with colleagues in the Department of Neurosurgery.

Strong Epilepsy Program at the University of Rochester Medical Center: Funded by New York State, federal and private support, this program brings state-of-the-art medical and surgical treatment to patients with epilepsy. Rochester is involved in multi-center clinical trials and in outcome research.

Neuromuscular Disease
Center grants funded by NINDS: Muscular Dystrophy Cooperative Research Center, Principal Investigator: Richard T. Moxley, III, M.D.; FOR-DMD: Finding the Optimum Corticosteroid regimen for Duchenne Muscular Dystrophy, Principal Investigator: Robert C. Griggs, M.D. The Muscle Study Group (MSG) Coordination Center is directed by Rabi Tawil, M.D. These provide the facilities and support for the conduct of major multi-center clinical trials, sponsored by NIH, FDA, many foundations and the pharmaceutical industry.

Child Neurology
The Child Neurology division trains fellows in subspecialty care and research in a wide spectrum of pediatric disorders. Ongoing work includes clinical trials (federal and private funding) as well as natural history, epidemiology, outcomes, and neurophysiology research. Jonathan Mink, M.D., Ph.D. is Co-Principal Investigator of the University of Rochester NeuroNEXT site, and of the Neurological Sciences Academic Development Award Program (NSADA, K12).

Under the direction of J. Steven Lamberti, MD, the Department of Psychiatry’s Schizophrenia Research Laboratory offers fellows an opportunity to participate in clinical trials that focus on the treatment of schizophrenia and related disorders. The Laboratory features NIH and industry sponsored studies involving novel compounds, with an emphasis on finding drugs that are more effective and have fewer side effects than currently available treatments.

Translational Neurology:  Design and Assessment

Health Services Delivery
Major programs in health services research with faculty who maintain joint appointments in the Department of Public Health Sciences, directed by Robert Holloway, M.D., M.P.H., Professor and Chair of Neurology.

Epidemiology and Statistics
Major interactions with the Department of Biostatistics and Computational Biology including full-time joint faculty appointments, (Michael McDermott, Ph.D. and Christopher Beck, Ph.D.) and major computer and programming resources.