Lynette Anne Desouza

Contact

• Email: lynette_desouza@urmc.rochester.edu
• Advisor: Dr. Robert S. Freeman
• Lab Website: Freeman Lab
• Program:
  • Interdepartmental Graduate Program in Neuroscience
• Phone: (585) 275-1282
• Address:

  University of Rochester Medical Center
  Box 603
  601 Elmwood Ave.
  Rochester, NY 14642

Area of Interest / Current Research

Molecular mechanisms of neuronal programmed cell death.

Education

• 2004-current : Ph.D. student, Neuroscience, University of Rochester
• 2001-2004: M.Sc. in Neuroscience, Tata Institute of Fundamental Research, Mumbai, India
• 1998-2001: B.Sc. in Lifescience/Biochemistry, St. Xaviers College, Mumbai, India

Publications

• Desouza LA, Ladiwala U, Daniel SM, Agashe S, Vaidya RA, Vaidya VA (2005) Thyroid hormone regulates hippocampal neurogenesis in the adult brain. Mol Cell Neurosci. 29 (3):414-426

Abstracts

• Desouza LA, Ladiwala U, Vaidya VA. (2004) Regulation of adult hippocampal neurogenesis by thyroid hormone. (Abstract) Society for Neuroscience
• Desouza LA and Vaidya VA (2003) Influence of altered thyroid hormone status on adult hipoocampal neurogenesis. (Abstract) Networks and Behavior symposium held the National Centre for Biological Sciences (NCBS), Bangalore, India
• Desouza LA, Ladiwala U, Agashe S, Vaidya RA, Vaidya VA. (2003) Thyroid regulation of adult hippocampal neurogenesis. (Abstract) International Symposium held at the National brain Research Centre (NBRC), Haryana, India

Rotations

These are some labs I have rotated through during my first year:

• David Kornack, Ph.D. Fall 2004
  My project involved characterizing the adult subventicular zone in vivo. This involved characterization of the progenitors within the subventicular zone as well as their interaction with other cells types that secrete and organize the extracellular matrix as well as factors that help maintain the neurogenic niche.
• Hermes Yeh, Ph.D. Spring 2005
  My project involved using an in vitro bioassay to detect acetylcholine release from septal cholinergic neurons. In order to study this, we co-cultured muscle cells with septal neurons and performed patch clamp recordings from muscle cells to measure any changes in acetylcholine release from cholinergic septal neurons.
• Robert Freeman, Ph.D. Summer 2005
  My project involved characterization of RNA interference vectors to knock down hypoxia inducible factors in PC12 cells in order to understand the role of these factors in PC12 cells exposed to hypoxia.