Ischemic neurons, hippocampus: In sharp contrast to the neurons in Slide 1; most of the neurons in this section of hippocampus exhibit a reddish or eosinophilic cytoplasm and pyknosis of the nucleus with loss of clear definition of nucleoli. This change is known as the acute eosinophilic nerve change, and is commonly seen in recent infarcts. It also is observed in hypoxia, hypoglycemia, and contusion of the brain; thus it represents a nonspecific form of acute neuronal necrosis. Note that four neurons on the left-hand side are spared, retaining characteristics similar to those seen in Slide 1.