2002
Grammas P, Yamada M, Zlokovic BV : The Cerebromicrovasculature: A key player in the pathogenesis of Alzheimer's disease. J Alzheimer's Disease 4(2002) 217-223.
Giri R, Selvaraj S, Miller C, Hofman F, Yan SD,
Stern D, Zlokovic BV, Kalra V: Effect of endothelial cell polarity on ß-amyloid-induced migration of monocytes across normal and AD endothelium
. AM J Physiol Cell Physiol 283: C895-904, 2002.
Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T,
Frangione B, Zlokovic BV: Circulating amyloid-ß peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascular Pharmacology 38(2002) 303-313.
Monro OR, Mackic JB, Yamada S, Segal MB, Ghiso J, Maurer C,
Calero M, Frangione B, Zlokovic BV: Substitution at codon 22 reduces clearance of Alzheimer's amyloid-ß peptide from the cerebrospinal fluid and prevents its transport from the
central nervous system into blood. Neurobiology of Aging 23(2002) 405-412.
Bading J, Yamada S, Mackic JB, Kirkman L, Miller C, Calero M,
Ghiso J, Frangione B, Zlokovic BV: Brain Clearance of Alzheimer's Amyloid-ß40 in the Squirrel Monkey: A SPECT Study in a Primate Model of Cerbral Amyloid Angiopathy. Journal of Drug Targeting 2002 Vol. 10(4), pp. 359-368.
Zlokovic BV.
Vascular risk factors for Alzheimer's Disease. Adv Drug Deliv Rev 54(2002) 1533-1537.
2001
Allende R, Teja S, Alleyne
CH: Microvascular decompression for trigeminal neuralgia. Neurology 57:1093, 2001.
Alleyne CH, Jr, Oyesiku
NM, Barrow DL, Tindall SC, Tindall GT: Combined, simultaneous pterional and
transsphenoidal approach to pituitary tumors. (In press)
Bakos R. Lecture,
7/14/01: Franz Schubert, His Musical Life and Medical History, Eastman School of Music.
Chen P, Shibata M,
Zidovetzki R, Fisher M, Zlokovic BV, Hofman FM. Endothelin-1 and monocyte chemoattractant
protein-1 modulation in ischemia and human brain-derived endothelial cell cultures. J Neuroimmunology 116, 62-73, 2001.
Cheng T,
Marlene Hosey. Interaction of b-tubulin with a1c subunit of voltage gated calcium channel.
Submitted to Circulation Research, 2001.
MacDonald TJ,
Taga T, Shimada H, Tabrizi P, Zlokovic BV, Cheresh DA.
Preferential susceptibility of brain tumors to the antiangiogenic
effects of an alpha(v) integrin antagonist. Neurosurgery 48 (1), 151-157, 2001.
Shibata M,
Subramanyan RK, Amar A, Fernandez J, Griffin J, Zlokovic BV. Anti-inflamatory,
antithrombotic and neuroprotective effects of activated protein C in a
murine model of focal ischemic stroke with cerebrovascular thrombosis Circulation 103: 1799-1805, 2001.
Tian Gao,
Adofo E. Cuadra, Hong Ma, Moritz Bunemann, Brian L. Gerhardstein, Tong Cheng, Robert Ten Eick and Marlene Hosey.
C-terminal fragments of the a1c subunit associate with
and regulate L-type calcium cannels containing C-terminally truncated a1c
subunits. Journal of Biological Chemistry 276: 21089-21097, 2001.
Zlokovic BV,
Cox C. Lower cognitive performance of older football players
possessing apolipoprotein E epsilon4. Neurosurgery 48 (5), 1196-1197, 2001.
2001 Research Papers-Peer Reviewed
Mackic JB,
Ghiso J, Frangione B, Kirkman L, Bading J, Zlokovic BV. Differential
cerebrovascular sequestration and enhanced blood-brain barrier
permeability to circulating Alzheimer's amyloid-ß peptide in aged
Rhesus vs. Aged Squirrel monkey. Gen Pharmacology Vasc Biol (in press), 2001.
2000
Alleyne CH,
Theodore N, Spetzler RF, Coons SW. Osteosarcoma of the
temporal fossa with hemorrhagic presentation: Case Report. Neurosurgery 47:447-451, 2000.
Alleyne CH,
Hassan M, Zabramski JM. The efficacy and cost of prophylactic
and periprocedural antibiotics in patients with external ventricular
drains. Neurosurgery 47:1124-1129, 2000.
Alleyne CH,
Numaguchi Y, Wang HZ. Transarterial embolization of a dural
arteriovenous fistula involving an isolated segment of the
superior petrosal sinus: Case report. Int Neurorad 6:337-341, 2000.
Benzakour O,
Kanthou C. The anticoagulant factor, protein S, is produced
by cultured human vascular smooth muscle cells and its expression
is up-regulated by thrombin. Blood 95: 2008-2014, 2000.
Bingaman KD, Alleyne CH, Jr. Olson JJ. Intracranial Extraskeletal
Mesenchymal Chondrosarcoma: Case Report. Neurosurgery 46:207-212, 2000.
Calero M,
Rostegno A, Matsubara E, Zlokovic BV, Ghiso J. Apolipoprotein J
(clusterin) and Alzheimer's disease. Micro Res Tech 50(4),
305-315, 2000.
Huang J,
Mocco J, Choudhri TF, Poisik A, Popilskis SJ, Emerson R, DelaPaz RL,
Khandji AG, Pinsky DJ, Connolly Jr ES, Zlokovic BV. A
Modified Transorbital Baboon Model of Reperfused Stroke/On Models
of Ischemic Stroke in Non-human Primates and Rodents. Stroke 31: 3054-3063, 2000.
Mac Donald T,
Tabrizi P, Shimada H, Zlokovic BV, Laug WE. Preferential
Susceptibility of Brain Tumors to the Anti-Angiogenic Effects of
an Alpha v-Integrin Antagonist. Neurosurgery 48(1): 151-157, 2000.
Ninomia T,
Wang L, Kumar R, Kim A, McComb G, Weiss MH, Zlokovic BV.
Brain injury and cerebrovascular fibrin deposition correlate with
reduced anti-thrombotic brain capillary functions in a hypertensive
stroke model. J Cereb Blood Flow Metab 20(6): 998-1009, 2000.
Numaguchi Y,
Wang HZ, Stern A, Alleyne CH, Lunsford LD. The arteriovenous
malformation associated with major arterial occlusion and Moyamoya
vessels: a cerebral blood flow study. Int Neurorad 6:185-193, 2000.
Subramanyan RK, Zlokovic BV. Anti-human fibrin antibodies cross react with
corresponding mouse fibrin. Arterioscler Thromb Vasc Biol 20(7):1848-49, 2000.
Shibata M,
Yamada S, Kumar RS, Calero M, Bading B, Frangione B, Holtzman DM,
Miller CA, Strickland DK, Ghiso J, Zlokovic BV. Clearance
of Alzheimer's Amyloid-ß1-40 Peptide from Brain by LDL
Receptor-Related Protein-1 at the Blood-Brain Barrier. J Clin Invest 106(12): 1489-1499, 2000.
Tokuda T,
Matsubara E, Calero M, Vidal R, Kumar A, Permanne B, Zlokovic BV,
Smith J, LaDu MJ, Rostagno A, Frangione B, Ghiso J. Lipidation
of apolipoprotein E influences its isoform specific interaction with
Alzheimer's amyloid ß.peptides. Biochem J 348, 359-365, 2000.
Sultana C,
Yamin S, Stins M, Yan SD, Schmidt AM, Stern D, Kim KS, Zlokovic BV,
Kalra VK. ß-Amyloid induced migration of monocytes across the
human brain endothelial cells is linked to RAGE and PECAM-1. Am J Physiology Cell Physiol 279, C1772-C1781, 2000.
Vishteh AG, Alleyne CH, Spetzler RF. Therapeutic carotid occlusion:
The case for prophylactic bypass. Clinical Neurosurgery 46:339-350, 2000.
Yan S-D,
Roher A, Chaney M, Zlokovic BV, Stern D, Schmidt A-M.
Cellular cofactors potentiating induction of stress and cytotoxicity
by amyloid beta-peptide. Biochim Biophys Acta 1502, 145-157, 2000.
Zhu NL,
Sosnowski BA, Zlokovic BV, Chen TC. Targeted Cytotoxic
Gene delivery to Malignant Gliomas via the Fibroblast Growth
Factor Receptor. Neurosurgical Focus 8(4), Article 4, 2000.
Zlokovic BV,
Jovanovic S, Miao W, Samara S, Verma S, Farrell C. Differential
regulation of leptin transport by the choroid plexus and blood-brain
barrier and high affinity transport systems for entry into
hypothalamus and across the blood-cerebrospinal fluid barrier. Endocrinology 141:4, 1434-1441, 2000.
Zlokovic BV,
Shinya Y, Holtzman D, Ghiso J, Frangione B. Clearance of
Amyloid ß-peptide from brain: transport or metabolism? Nature Med. 6, 718-719. 2000.
1999
Alleyne
CH Jr,
Barrow DL, Joseph G. Surgical management of angiographically
occult spinal dural arteriovenous fistulae (Type I spinal arteriovenous
malformations): Three technical case reports. Neurosurgery 44(4): 891-894, discussion 894-895, 1999.
Alleyne
CH Jr,
He J, Yang J, Hunter SB, Cotsonis G, James CD, Olson JJ. Analysis
of cyclin dependent kinase inhibitors in malignant astrocytomas. Int J Oncol 14(6): 1111-1116, 1999.
Alleyne
CH Jr,
McDougall CG, Spetzler RF, Vishteh AG. Dolichoectatic basilar
artery aneurysm treated with superficial temporal artery-to-superior
cerebellar artery bypass and coiling: Case report. BNI Quarterly 15(4): 23-25, 1999.
Alleyne
CH Jr,
Spetzler RF. What determines the risk of hemorrhage from cerebral
arteriovenous malformations? Critical Reviews in Neurosurgery 9(2): 87-95, 1999.
Alleyne
CH Jr,
Vishteh AG, Spetzler RF. Cerebellopontine angle glioblastoma
multiforme with ventricular metastases: Case report. BNI
Quarterly 15(4): 18-20, 1999.
Alleyne
CH Jr,
Vishteh AG, Spetzler RF, Detwiler PW. Long-term survival of
a patient with invasive cranial base rhinocerebral mucormycosis
treated with combined endovascular, surgical, and medical therapies:
Case report. Neurosurgery 45(6): 1461, 1999.
Chun
JT, Wang L, Pasinetti GM, Finch CE, Zlokovic BV. Glycoprotein
330/megalin (LRP-2) has low prevalence as mRNA and protein in
brain microvessels and choroid plexus. Exp Neurol 157(1):
194-201, 1999.
Imai
F, Sawada M, Suzuki H, Zlokovic BV, Kojima J, Kuno S,
Nagatsu T, Nitatori T, Uchiyama Y, Kanno T. Exogenous microglia
enter the brain and migrate into ischaemic hippocampal lesions. Neurosci Lett 272(2): 127-130, 1999.
Iwanaga
S, Shrier DA, Okawara SH, Numaguchi Y. Value of CT angiography
in the evaluation of a peripheral anterior inferior cerebellar
artery aneurysm: Case report. Clin Imaging 23(2): 77-80,
1999.
Kannan
R, Mackic JB, Zlokovic BV. Corneal transport of circulating
glutathione in normal and galactosemic guinea pigs. Cornea 18(3): 321-327, 1999.
Mackic
JB, Stins M, Jovanovic S, Kim KS, Bartus RT, Zlokovic BV.
Cereport (RMP-7) increases the permeability of human brain microvascular
endothelial cell monolayers. Pharm Res 16(9): 1360-1365,
1999.
Tabrizi
P, Wang L, Seeds N, McComb JG, Yamada S, Griffin JH, Carmeliet
P, Weiss MH, Zlokovic BV. Tissue plasminogen activator
(tPA) deficiency exacerbates cerebrovascular fibrin deposition
and brain injury in a murine stroke model: Studies in tPA-deficient
mice and wild-type mice on a matched genetic background. Arterioscler
Thromb Vasc Biol 19(11): 2801-2806, 1999.
Yu
H, Wang Y, Eton D, Stins M, Wang L, Apuzzo ML, Weaver FA, McComb
JG, Weiss MH, Zlokovic BV. Retroviral vector-mediated
transfer and expression of human tissue plasminogen activator
cDNA in bovine brain endothelial cells. Neurosurgery 45(4): 962-968, discussion 968-970, 1999.
1998
Alleyne
CH Jr,
Cawley CM, Barrow DL, Bonner GD. Microsurgical anatomy of the
dorsal cervical nerve roots and the cervical dorsal root ganglion/ventral
root complexes. Surg Neurol 50(3): 213-218, 1998.
Alleyne
CH Jr,
Cawley CM, Shengelaia GG, Barrow DL. Microsurgical anatomy of
the artery of Adamkiewicz and its segmental artery. J Neurosurg 89(5): 791-795, 1998.
Alleyne
CH Jr,
Hunter S, Olson JJ, Barrow DL. Lipomatous glioneurocytoma of
the posterior fossa with divergent differentiation: Case report. Neurosurgery 42(3): 639-643, 1998.
Kirsch
M, Strasser J, Allende R, Bello L, Zhang J, Black PMcL.
Angiostatin suppresses malignant glioma growth in vivo. Cancer
Research 58: 4654-4659, 1998.
Lavine
SD, Hofman FM, Zlokovic BV. Circulating antibody against
tumor necrosis factor-alpha protects rat brain from reperfusion
injury. J Cereb Blood Flow Metab 18(1): 52-58, 1998.
LeMay
DR, Kittaka M, Gordon EM, Gray B, Stins MF, McComb JG, Jovanovic
S, Tabrizi P, Weiss MH, Bartus R, Anderson WF, Zlokovic BV.
Intravenous RMP-7 increases delivery of ganciclovir into rat
brain tumors and enhances the effects of herpes simplex virus
thymidine kinase gene therapy. Hum Gene Ther 9(7): 989-995,
1998.
MacDonald
TJ, Tabrizi P, Shimada H, Zlokovic BV, Laug WE. Detection
of brain tumor invasion and micrometastasis in vivo by expression
of enhanced green fluorescent protein. Neurosurgery 43(6):
1437-1442, discussion 1442-1443, 1998.
Mackic
JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern
D, Schmidt AM, Frangione B, Zlokovic BV. Human blood-brain
barrier receptors for Alzheimer's amyloid-beta 1-40. Asymmetrical
binding, endocytosis, and transcytosis at the apical side of
brain microvascular endothelial cell monolayer. J Clin Invest 102(4): 734-743, 1998.
Mackic
JB, Weiss MH, Miao W, Kirkman E, Ghiso J, Calero M, Bading J,
Frangione B, Zlokovic BV. Cerebrovascular accumulation
and increased blood-brain barrier permeability to circulating
Alzheimer's amyloid beta peptide in aged squirrel monkey with
cerebral amyloid angiopathy. J Neurochem 70(1): 210-215,
1998.
Mullins
KJ, Rubio A, Myers SP, Korones DN, Pilcher WH. Malignant
ependymomas in a patient with Turcot's syndrome: Case report
and management guidelines. Surg Neurol 49(3): 290-294,
1998.
Schreiber
SS, Tan Z, Sun N, Wang L, Zlokovic BV. Immunohistochemical
localization of tissue plasminogen activator in vascular endothelium
of stroke-prone regions of the rat brain. Neurosurgery 43(4): 909-913, 1998.
Wang
L, Tran ND, Schreiber SS, Fisher M, Zlokovic BV. Rat
brain capillary thrombomodulin: Structure and function. Thromb
Res 92(5): 213-219, 1998.
Yamada
K, Shrier DA, Tanaka H, Okawara SH. Cerebral giant aneurysm
with extensive vasogenic edema. Radiat Med 16(4): 305-307,
1998.
Yoshiura
T, Shrier DA, Pilcher WH, Rubio A. Cervical spinal meningioma
with unusual MR contrast enhancement. AJNR Am J Neuroradiol 19(6): 1040-1042, 1998.
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