Clinical Trials

RTOG 0614:
Brain Metastases study testing Investigational drug versus Placebo for Prevention of Cognitive Problems from Whole Brain Radiation Therapy

The purpose of this study is to compare the effects, good and/or bad, of memantine with a placebo on memory and thinking in participants receiving whole brain radiotherapy. Doctors hope that memantine will be effective in preventing thinking problems after whole brain radiotherapy, although there is no proof of this yet. In this study, subjects will get either memantine or the placebo. In addition, we want to find out what effects, good and/or bad, memantine has on participants and their brain tumors. Memantine is currently used to help with thinking and memory for people with different types of dementia. A placebo is a non-active substance that looks the same as, and is given the same way as, an active drug being tested. The effects of the active drug are compared to the effects of the placebo.

For more info, contact Cindy Gu at 585-275-2525