2003

Lin JH, Yang J, Liu S, Takano T, Wang X, Gao Q, Willecke K, Nedergaard M (2003, Jan). Connexin mediates gap junction-independent resistance to cellular injury. Journal of Neuroscience, 23 (2): 430-441.

Amar AP, Zlokovic BV , Apuzzo ML (2003, Feb). Endovascular restorative neurosurgery: a novel concept for molecular and cellular therapy of the nervous system. Neurosurgery. 52 (2): 402-412.

Cheng T , Liu D, Griffin JH, Fernandez JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV . (2003, Mar). Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nature Medicine, 9 (3): 338-342.

Liu D , Guo H , Griffin JH, Fernandez JA, Zlokovic BV . (2003, Apr). Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation, 107 (13): 1791-1796.

Nunes MC, Roy NS, Keyoung HM, Goodman RR, McKhann G 2 nd , Jiang L, Kang J, Nedergaard M, Goldman SA (2003, Apr). Indentification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nature Medicine, 9 (4): 439-447.

Fernandez JA, Xu X, Liu D , Zlokovic BV , Griffin JH (2003, May-Jun). Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells, Molecules, and Diseases, 30 (3): 271-276.

Domotor E , Benzakour O , Griffin JH, Yule D, Fukudome K, Zlokovic BV (2003, Jun). Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood, 101 : 4797-4801.

Deane R , Du Yan S, Submamaryan RK, Larue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofmann F, Kindy M, Stern D, Zlokovic B (2003, Jul). RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nature Medicine, 9 (7): 907-913.

Anderson CM, Nedergaard M (2003, Jul). Astrocyte-mediated control of cerebral microcirculation. Trends in Neurosciences, 26 (7): 340-344; author reply 344-345.

Alleyne CH , Vishteh AG, Spetzler RF (2003, Oct). Traumatic carotid injury. In: Youmans Neurological Surgery , HR Winn, ed. W.B. Saunders, p. 1669-1676.

Alburquerque FC, Alleyne CH , Baskin JJ, McDougall CG (2003, Oct). Carotid angioplasty and stenting: Interventional treatment of occlusive vascular disease. In: Youmans Neurological Surgery , HR Winn, ed. W.B. Saunders, p. 1651-1660.

Nedergaard M, Ransom B, Goldman SA (2003, Oct). New roles for astrocytes: redefining the functional architecture of the brain. Trends in Neurosciences, 26 (10): 523-530.

Simard M, Arcuino G, Takano T, Liu QS, Nedergaard M (2003, Oct). Signaling at the gliovascular interface. Journal of Neuroscience, 23 (27): 9254-9262.

Ransom B., Behar T., Nedergaard M (2003, Oct). New roles for astrocytes (stars at last). Trends in Neurosciences, 26 (10): 520-522.

Pilcher WH (2003, Oct). Epilepsy surgery: Outcome and complications. In: Youmans Neurological Surgery , HR Winn, ed. W.B. Saunders, p. 2565-2585.

Filbrant CR, Wu Z, Zlokovic BV (2003, Oct). Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes. Neurotoxicology , online: 10.1016/j.neuro.2003.08.007.

Wu Z, Hofman FM, Zlokovic BV (2003, Nov). A simple method for isolation and characterization of mouse brain microvascular endothelial cells. Journal of Neuroscience Methods, 130 (1): 53-63.

Tomlin JM, Alleyne CH (2003, Dec). Fusiform aneurysmal dilation of the vertebral and basilar arteries: natural history, pathophysiology, and current treatment options. Contemporary Neurosurgery , 25 (26): 8 pages.

Zlokovic BV, and Frangione, B. (2003). Transport-clearance hypothesis for Alzheimer's disease and potential therapeutic implications. In: Aß Metabolism and Alzheimer's Disease . T. Saido, ed. Landes Bioscience, p. 114-122.

2002

Grammas P, Yamada M, Zlokovic BV : The Cerebromicrovasculature: A key player in the pathogenesis of Alzheimer's disease. J Alzheimer's Disease 4(2002) 217-223.

Giri R, Selvaraj S, Miller C, Hofman F, Yan SD, Stern D, Zlokovic BV, Kalra V: Effect of endothelial cell polarity on ß-amyloid-induced migration of monocytes across normal and AD endothelium . AM J Physiol Cell Physiol 283: C895-904, 2002.

Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, Zlokovic BV: Circulating amyloid-ß peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascular Pharmacology 38(2002) 303-313.

Monro OR, Mackic JB, Yamada S, Segal MB, Ghiso J, Maurer C, Calero M, Frangione B, Zlokovic BV: Substitution at codon 22 reduces clearance of Alzheimer's amyloid-ß peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiology of Aging 23(2002) 405-412.

Bading J, Yamada S, Mackic JB, Kirkman L, Miller C, Calero M, Ghiso J, Frangione B, Zlokovic BV: Brain Clearance of Alzheimer's Amyloid-ß40 in the Squirrel Monkey: A SPECT Study in a Primate Model of Cerbral Amyloid Angiopathy. Journal of Drug Targeting 2002 Vol. 10(4), pp. 359-368.

Zlokovic BV. Vascular risk factors for Alzheimer's Disease. Adv Drug Deliv Rev 54(2002) 1533-1537.

2001

Allende R, Teja S, Alleyne CH: Microvascular decompression for trigeminal neuralgia. Neurology 57:1093, 2001.

Alleyne CH, Jr, Oyesiku NM, Barrow DL, Tindall SC, Tindall GT: Combined, simultaneous pterional and transsphenoidal approach to pituitary tumors. (In press)

Bakos R. Lecture, 7/14/01: Franz Schubert, His Musical Life and Medical History, Eastman School of Music.

Chen P, Shibata M, Zidovetzki R, Fisher M, Zlokovic BV, Hofman FM. Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures. J Neuroimmunology 116, 62-73, 2001.

Cheng T, Marlene Hosey. Interaction of b-tubulin with a1c subunit of voltage gated calcium channel. Submitted to Circulation Research, 2001.

MacDonald TJ, Taga T, Shimada H, Tabrizi P, Zlokovic BV, Cheresh DA. Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist. Neurosurgery 48 (1), 151-157, 2001.

Shibata M, Subramanyan RK, Amar A, Fernandez J, Griffin J, Zlokovic BV. Anti-inflamatory, antithrombotic and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke with cerebrovascular thrombosis Circulation 103: 1799-1805, 2001.

Tian Gao, Adofo E. Cuadra, Hong Ma, Moritz Bunemann, Brian L. Gerhardstein, Tong Cheng, Robert Ten Eick and Marlene Hosey. C-terminal fragments of the a1c subunit associate with and regulate L-type calcium cannels containing C-terminally truncated a1c subunits. Journal of Biological Chemistry 276: 21089-21097, 2001.

Zlokovic BV, Cox C. Lower cognitive performance of older football players possessing apolipoprotein E epsilon4. Neurosurgery 48 (5), 1196-1197, 2001.

2001 Research Papers-Peer Reviewed

Mackic JB, Ghiso J, Frangione B, Kirkman L, Bading J, Zlokovic BV. Differential cerebrovascular sequestration and enhanced blood-brain barrier permeability to circulating Alzheimer's amyloid-ß peptide in aged Rhesus vs. Aged Squirrel monkey. Gen Pharmacology Vasc Biol (in press), 2001.

2000

Alleyne CH, Theodore N, Spetzler RF, Coons SW. Osteosarcoma of the temporal fossa with hemorrhagic presentation: Case Report. Neurosurgery 47:447-451, 2000.

Alleyne CH, Hassan M, Zabramski JM. The efficacy and cost of prophylactic and periprocedural antibiotics in patients with external ventricular drains. Neurosurgery 47:1124-1129, 2000.

Alleyne CH, Numaguchi Y, Wang HZ. Transarterial embolization of a dural arteriovenous fistula involving an isolated segment of the superior petrosal sinus: Case report. Int Neurorad 6:337-341, 2000.

Benzakour O, Kanthou C. The anticoagulant factor, protein S, is produced by cultured human vascular smooth muscle cells and its expression is up-regulated by thrombin. Blood 95: 2008-2014, 2000.

Bingaman KD, Alleyne CH, Jr. Olson JJ. Intracranial Extraskeletal Mesenchymal Chondrosarcoma: Case Report. Neurosurgery 46:207-212, 2000.

Calero M, Rostegno A, Matsubara E, Zlokovic BV, Ghiso J. Apolipoprotein J (clusterin) and Alzheimer's disease. Micro Res Tech 50(4), 305-315, 2000.

Huang J, Mocco J, Choudhri TF, Poisik A, Popilskis SJ, Emerson R, DelaPaz RL, Khandji AG, Pinsky DJ, Connolly Jr ES, Zlokovic BV. A Modified Transorbital Baboon Model of Reperfused Stroke/On Models of Ischemic Stroke in Non-human Primates and Rodents. Stroke 31: 3054-3063, 2000.

Mac Donald T, Tabrizi P, Shimada H, Zlokovic BV, Laug WE. Preferential Susceptibility of Brain Tumors to the Anti-Angiogenic Effects of an Alpha v-Integrin Antagonist. Neurosurgery 48(1): 151-157, 2000.

Ninomia T, Wang L, Kumar R, Kim A, McComb G, Weiss MH, Zlokovic BV. Brain injury and cerebrovascular fibrin deposition correlate with reduced anti-thrombotic brain capillary functions in a hypertensive stroke model. J Cereb Blood Flow Metab 20(6): 998-1009, 2000.

Numaguchi Y, Wang HZ, Stern A, Alleyne CH, Lunsford LD. The arteriovenous malformation associated with major arterial occlusion and Moyamoya vessels: a cerebral blood flow study. Int Neurorad 6:185-193, 2000.

Subramanyan RK, Zlokovic BV. Anti-human fibrin antibodies cross react with corresponding mouse fibrin. Arterioscler Thromb Vasc Biol 20(7):1848-49, 2000.

Shibata M, Yamada S, Kumar RS, Calero M, Bading B, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV. Clearance of Alzheimer's Amyloid-ß1-40 Peptide from Brain by LDL Receptor-Related Protein-1 at the Blood-Brain Barrier. J Clin Invest 106(12): 1489-1499, 2000.

Tokuda T, Matsubara E, Calero M, Vidal R, Kumar A, Permanne B, Zlokovic BV, Smith J, LaDu MJ, Rostagno A, Frangione B, Ghiso J. Lipidation of apolipoprotein E influences its isoform specific interaction with Alzheimer's amyloid ß.peptides. Biochem J 348, 359-365, 2000.

Sultana C, Yamin S, Stins M, Yan SD, Schmidt AM, Stern D, Kim KS, Zlokovic BV, Kalra VK. ß-Amyloid induced migration of monocytes across the human brain endothelial cells is linked to RAGE and PECAM-1. Am J Physiology Cell Physiol 279, C1772-C1781, 2000.

Vishteh AG, Alleyne CH, Spetzler RF. Therapeutic carotid occlusion: The case for prophylactic bypass. Clinical Neurosurgery 46:339-350, 2000.

Yan S-D, Roher A, Chaney M, Zlokovic BV, Stern D, Schmidt A-M. Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide. Biochim Biophys Acta 1502, 145-157, 2000.

Zhu NL, Sosnowski BA, Zlokovic BV, Chen TC. Targeted Cytotoxic Gene delivery to Malignant Gliomas via the Fibroblast Growth Factor Receptor. Neurosurgical Focus 8(4), Article 4, 2000.

Zlokovic BV, Jovanovic S, Miao W, Samara S, Verma S, Farrell C. Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier. Endocrinology 141:4, 1434-1441, 2000.

Zlokovic BV, Shinya Y, Holtzman D, Ghiso J, Frangione B. Clearance of Amyloid ß-peptide from brain: transport or metabolism? Nature Med. 6, 718-719. 2000.

1999

Alleyne CH Jr, Barrow DL, Joseph G. Surgical management of angiographically occult spinal dural arteriovenous fistulae (Type I spinal arteriovenous malformations): Three technical case reports. Neurosurgery 44(4): 891-894, discussion 894-895, 1999.

Alleyne CH Jr, He J, Yang J, Hunter SB, Cotsonis G, James CD, Olson JJ. Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas. Int J Oncol 14(6): 1111-1116, 1999.

Alleyne CH Jr, McDougall CG, Spetzler RF, Vishteh AG. Dolichoectatic basilar artery aneurysm treated with superficial temporal artery-to-superior cerebellar artery bypass and coiling: Case report. BNI Quarterly 15(4): 23-25, 1999.

Alleyne CH Jr, Spetzler RF. What determines the risk of hemorrhage from cerebral arteriovenous malformations? Critical Reviews in Neurosurgery 9(2): 87-95, 1999.

Alleyne CH Jr, Vishteh AG, Spetzler RF. Cerebellopontine angle glioblastoma multiforme with ventricular metastases: Case report. BNI Quarterly 15(4): 18-20, 1999.

Alleyne CH Jr, Vishteh AG, Spetzler RF, Detwiler PW. Long-term survival of a patient with invasive cranial base rhinocerebral mucormycosis treated with combined endovascular, surgical, and medical therapies: Case report. Neurosurgery 45(6): 1461, 1999.

Chun JT, Wang L, Pasinetti GM, Finch CE, Zlokovic BV. Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus. Exp Neurol 157(1): 194-201, 1999.

Imai F, Sawada M, Suzuki H, Zlokovic BV, Kojima J, Kuno S, Nagatsu T, Nitatori T, Uchiyama Y, Kanno T. Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions. Neurosci Lett 272(2): 127-130, 1999.

Iwanaga S, Shrier DA, Okawara SH, Numaguchi Y. Value of CT angiography in the evaluation of a peripheral anterior inferior cerebellar artery aneurysm: Case report. Clin Imaging 23(2): 77-80, 1999.

Kannan R, Mackic JB, Zlokovic BV. Corneal transport of circulating glutathione in normal and galactosemic guinea pigs. Cornea 18(3): 321-327, 1999.

Mackic JB, Stins M, Jovanovic S, Kim KS, Bartus RT, Zlokovic BV. Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers. Pharm Res 16(9): 1360-1365, 1999.

Tabrizi P, Wang L, Seeds N, McComb JG, Yamada S, Griffin JH, Carmeliet P, Weiss MH, Zlokovic BV. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: Studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler Thromb Vasc Biol 19(11): 2801-2806, 1999.

Yu H, Wang Y, Eton D, Stins M, Wang L, Apuzzo ML, Weaver FA, McComb JG, Weiss MH, Zlokovic BV. Retroviral vector-mediated transfer and expression of human tissue plasminogen activator cDNA in bovine brain endothelial cells. Neurosurgery 45(4): 962-968, discussion 968-970, 1999.

1998

Alleyne CH Jr, Cawley CM, Barrow DL, Bonner GD. Microsurgical anatomy of the dorsal cervical nerve roots and the cervical dorsal root ganglion/ventral root complexes. Surg Neurol 50(3): 213-218, 1998.

Alleyne CH Jr, Cawley CM, Shengelaia GG, Barrow DL. Microsurgical anatomy of the artery of Adamkiewicz and its segmental artery. J Neurosurg 89(5): 791-795, 1998.

Alleyne CH Jr, Hunter S, Olson JJ, Barrow DL. Lipomatous glioneurocytoma of the posterior fossa with divergent differentiation: Case report. Neurosurgery 42(3): 639-643, 1998.

Kirsch M, Strasser J, Allende R, Bello L, Zhang J, Black PMcL. Angiostatin suppresses malignant glioma growth in vivo. Cancer Research 58: 4654-4659, 1998.

Lavine SD, Hofman FM, Zlokovic BV. Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury. J Cereb Blood Flow Metab 18(1): 52-58, 1998.

LeMay DR, Kittaka M, Gordon EM, Gray B, Stins MF, McComb JG, Jovanovic S, Tabrizi P, Weiss MH, Bartus R, Anderson WF, Zlokovic BV. Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy. Hum Gene Ther 9(7): 989-995, 1998.

MacDonald TJ, Tabrizi P, Shimada H, Zlokovic BV, Laug WE. Detection of brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein. Neurosurgery 43(6): 1437-1442, discussion 1442-1443, 1998.

Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J Clin Invest 102(4): 734-743, 1998.

Mackic JB, Weiss MH, Miao W, Kirkman E, Ghiso J, Calero M, Bading J, Frangione B, Zlokovic BV. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy. J Neurochem 70(1): 210-215, 1998.

Mullins KJ, Rubio A, Myers SP, Korones DN, Pilcher WH. Malignant ependymomas in a patient with Turcot's syndrome: Case report and management guidelines. Surg Neurol 49(3): 290-294, 1998.

Schreiber SS, Tan Z, Sun N, Wang L, Zlokovic BV. Immunohistochemical localization of tissue plasminogen activator in vascular endothelium of stroke-prone regions of the rat brain. Neurosurgery 43(4): 909-913, 1998.

Wang L, Tran ND, Schreiber SS, Fisher M, Zlokovic BV. Rat brain capillary thrombomodulin: Structure and function. Thromb Res 92(5): 213-219, 1998.

Yamada K, Shrier DA, Tanaka H, Okawara SH. Cerebral giant aneurysm with extensive vasogenic edema. Radiat Med 16(4): 305-307, 1998.

Yoshiura T, Shrier DA, Pilcher WH, Rubio A. Cervical spinal meningioma with unusual MR contrast enhancement. AJNR Am J Neuroradiol 19(6): 1040-1042, 1998.