MADIT-RIT Delivers Major Change in Defibrillator Therapy

Since the 1990’s, the Multicenter Automatic Defibrillator Implantation Trial (MADIT) research group, led by Professor Arthur J. Moss, M.D., has shaped the use of implantable cardioverter defibrillators and cardiac resynchronization therapy defibrillators worldwide. The group’s newest study, MADIT-RIT (Reduce Inappropriate Therapy), delivers more practice-changing results that will make the utilization of ICDs and CRT-Ds safer, more effective, and better tolerated by patients.

Arthur J. Moss, M.D., Professor of Cardiology at the University of Rochester Medical Center, reviews the findings and implications of the MADIT-RIT trial -- the first large-scale, randomized study designed to evaluate specific programming features to reduce inappropriate therapy in patients with ICDs. In the study, published in the New England Journal of Medicine, Dr. Moss and his team reveal a new, simple formula that dramatically reduced inappropriate therapies and increased survival in patients with heart disease.