Wilmot Urologist Earns Grant to Study Inflammation and Prostate Cancer

August 28, 2006

James P. Wilmot Cancer Center urologist Ganesh Palapattu, M.D., received a prestigious Prostate Cancer Foundation grant to study whether bone marrow-derived cells found in inflamed prostates contribute to the formation of the disease.

There is a growing body of research that links cellular inflammation to a variety of cancers, including esophagus, stomach, liver, large intestine and bladder cancers. Recently, scientists have found that bone marrow-derived cells are able to regenerate tissue in the body following injury and may contribute to the development of cancer in chronically inflamed organs. Palapattu’s pre-clinical research may shed new light on the role of inflammation and bone marrow cells in the development of prostate cancer.

“This is a new way to think about prostate cancer development,” said Palapattu, assistant professor of Urology. “The process of prostate inflammation may trigger responses by specialized cells from the bone marrow that may then become involved in prostate cancer formation.”

In the United States, one in 10 men gets prostate cancer, making it one of the most common forms of cancer among men ages 45 and up. Approximately 27,000 men will die from it this year, and about 235,000 new cases will be diagnosed, according to the American Cancer Society.

Palapattu began his work on inflammation, bone marrow derived cells and prostate cancer at Johns Hopkins prior to arriving here in Rochester last September. The $100,000 grant from the Prostate Cancer Foundation will support his continued research in this area.

The Wilmot Cancer Center is the Finger Lakes region’s leader in cancer care and research. 

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