J. Edward Puzas, Ph.D.

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Edward Puzas is an international leader in research and treatment of diseases related to bones, joints, and cartilage. These conditions include osteoporosis, slow-healing fractures, arthritis, and bone cancer.

Puzas has served as president of the United States Bone and Joint Decade, an organization dedicated to improving research, public awareness and treatment of bone and joint disorders. He has also been president of the Orthopaedic Research Society. In both roles he guided the priorities of orthopaedic researchers nationwide.

At Rochester Puzas is a founder of the Center for Musculoskeletal Research, where researchers and clinicians work together to develop new treatments for diseases like osteoporosis. His leadership is essential to a department that consistently ranks among the top nationally in terms of research funding from the National Institutes of Health for orthopedic-related conditions.

Puzas’ scientific projects include tracking down the molecular signals that govern osteoporosis and arthritis, as well as cellular changes that can lead to difficulties such as the loosening of artificial joints. An area of unique strength is Puzas’ knowledge of environmental toxins such as lead, and how exposures play a role in bone and joint diseases.

Beyond basic research, Puzas is also a clinical trials investigator. In one recent project, Puzas and colleagues have shown that a medication currently on the market for osteoporosis can stimulate the body’s stem cells and boost the body’s ability to heal a slow-to-mend fracture.

Such wide research interests are made possible by his knowledge in many areas beyond orthopaedics; indeed, Puzas also has academic appointments in the departments of Biochemistry and Biophysics, Environmental Medicine, and Biomedical Engineering.

Topics:

  • Osteoporosis
  • Fractures
  • Osteoarthritis
  • Bone health
  • Osteotoxicology

Donald and Mary Clark Professor of Orthopaedics

Senior Associate Dean for Basic Research

University of Rochester Medical Center

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