NYICE Publications
Biochemical impact of the host adaptation associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex. Aggarwal: JBC/2011/262048 (Accepted Aug 2011)
Comprehensive Proteomic Analysis of Influenza Virus Polymerase Complex Reveals a Novel Association with Mitochondrial Proteins and RNA Polymerase Accessory Factors. Bradel-Tretheway, B. G., J. L. Mattiacio, A. Krasnoselsky, C. Stevenson, D. Purdy, S. Dewhurst, and M. G. Katze. 29 June 2011. J. Virol. doi:10.1128/JVI.00496-11. PMID21715506
The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity. Richards KA, Chaves FA, Sant AJ. Immunology. 2011 Jun;133(2):246-56. doi: 10.1111/j.1365-2567.2011.03435.x. Epub 2011 Mar 29. PMID21517839 PMCID: PMC3088986[Available on 2012/6/1]
Rapid Reactivation of Extralymphoid CD4 T cells During Secondary Infection. Timothy J Chapman, PhD;Kris Lambert;David J Topham, PhD. Accepted (PONE-D-10-01664R2)
Biophysical analysis of influenza A virus RNA promoter at physiological temperatures. Noble E, Mathews DH, Chen JL, Turner DH, Takimoto T, Kim B. Accepted (JBC/2011/239509)
PA residues in the 2009 H1N1 pandemic influenza virus enhance avian virus polymerase activity in mammalian cells. Kendra A. Bussey, Emily A. Desmet, Jonelle L. Mattiacio, Alice Hamilton1, Birgit Bradel-Tretheway2, Howard E. Bussey3, Baek Kim, Stephen Dewhurst, Toru Takimoto. Accepted (JVI00522-11 Version 2)
CD8+ T Cell Immunity to 2009 Pandemic and Seasonal H1N1 Influenza Viruses. Kristin Scheible, Gang Zhang, Jane Baer, Mitra Azadniva, Kris Lamberta, Gloria Pryhuberb, John J. Treanora, and David J. Topham. Vaccine. 2011 Mar 3;29(11):2159-68. Epub 2011 Jan 4. PMID: 21211588 [PubMed - in process] PMCID: PMC3061835 [Available on 2012/3/3]
T cell mediated protection against lethal 2009 pandemic H1N1 influenza infection in a mouse model. Guo H, Santiago F, Lambert K, Takimoto T, and Topham DJ. J Virology PMID20980523 PMCID: PMC3014175 [Available on 2011/7/1]
CD4 T cells generated from encounter with the seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus. Richards KA., Topham DT, Chaves FA, Sant AJ (2010). Cutting Edge: J. Immunol. In Press.2010 Oct JI1001395 PMID20889549
Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virus. Sun X, Tse LV, Ferguson AD, Whittaker GR. J Virol. 2010 Sep;84(17):8683-90. Epub 2010 Jun 16.PMID: 20554779 [PubMed - indexed for MEDLINE] PMID20554779 PMCID: PMC2919019
Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex. Aggarwal S, Bradel-Tretheway B, Takimoto T, Dewhurst S, Kim B. PLoS One. 2010 Apr 29;5(4):e10372.PMID: 20454455 [PubMed - in process] PMID20454455 PMCID: PMC2861597
Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins. Nayak JL, Richards KA, Chaves FA, Sant AJ. Viral Immunol. 2010 Apr;23(2):169-80.PMID: 20373997 [PubMed - indexed for MEDLINE] PMID20373997 PMCID: PMC2883523
Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1. Chapman TJ, Topham DJ. J Immunol. 2010 Apr 1;184(7):3841-9. Epub 2010 Mar 3.PMID: 20200271 [PubMed - indexed for MEDLINE] PMID20200271 PMCID: PMC2843798
Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB. Virology. 2010 May 10;400(2):224-32. Epub 2010 Feb 25.PMID: 20185156 [PubMed - indexed for MEDLINE] PMID20185156 PMCID: PMC2844475 [Available on 2011/5/10]
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. Kendra A. Bussey, Tatiana L. Bousse,† Emily A. Desmet, Baek Kim, and Toru Takimoto. J Virol. 2010 May; 84(9): 4395–4406. Published online 2010 February 24. doi: 10.1128/JVI.02642-09. PMID20181719 PMC2863787
B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant. Baer J, Santiago F, Yang H, Wu H, Holden-Wiltse J, Treanor J, Topham DJ. Vaccine. 2010 Jan 22;28(4):907-15. Epub 2009 Nov 21.PMID: 19932673 [PubMed - indexed for MEDLINE] PMID19932673 PMCID: PMC2814950
Abortive activation of CD4 T cell responses during competitive priming in vivo. Weaver JM, Chaves FA, Sant AJ. Proc Natl Acad Sci U S A. 2009 May 6;106(21):8647-52. Epub 2009 May 7.PMID: 19423666 [PubMed - indexed for MEDLINE] PMID19423666 PMCID: PMC2689016
Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus. Richards KA, Chaves FA, Sant AJ. J Virol. 2009 Jul;83(13):6566-77. Epub 2009 Apr 22.PMID: 19386707 [PubMed - indexed for MEDLINE] PMID19386707 PMCID: PMC2698557
The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit. Bradel-Tretheway BG, Kelley Z, Chakraborty-Sett S, Takimoto T, Kim B, Dewhurst S. J Gen Virol. 2008 Dec;89(Pt 12):2923-32. PMID: 19008377 [PubMed - indexed for MEDLINE] PMCID: PMC3067610
Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design. Weaver JM, Lazarski CA, Richards KA, Chaves FA, Jenks SA, Menges PR, Sant AJ. J Immunol. 2008 Sep 1;181(5):3039-48. PMID: 18713974 [PubMed - indexed for MEDLINE] PMCID: PMC2814425
