NYICE Publications
2013
Tung J, Sant AJ.
Orchestration of CD4 T cell epitope preferences after multi-peptide immunization.
J Immunol. [Accepted]
2013 Apr 23
Hamilton, BS, Whittaker GR.
Cleavage activation of the human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12.
J Biol Chem
2013 Feb 28
Tse LV, Marcano VC, Huang W, Pocwierz MS, Whittaker GR.
Plasmin-mediated activation of pandemic H1N1 influenza virus hemagglutinin independent of the viral neuraminidase.
J Virol.
2013 Jan
Desmet EA, Bussey KA, Stone R, Takimoto T.
Identification of the N-terminal domain of influenza PA responsible for the suppression of host protein synthesis.
J Virol. 87(6):3108-18
2012 Nov 27
Bialas KM, Desmet EA, Takimoto T.
Specific Residues in the 2009 H1N1 Swine-Origin Influenza Matrix Protein Influence Virion Morphology and Efficiency of Viral Spread in vitro.
PLoS One. 7(11):e50595
2012 Nov 12
Nayak JL, Fitzgerald TF, Richards KA, Yang H, Treanor JJ, Sant AJ.
CD4 T-cell expansion predicts neutralizing antibody responses to monovalent inactivated pandemic H1N1 influenza vaccine.
J Infect Dis. 207(2):297-305
2012 Oct 22
Richards KA, Chaves FA, Alam S, Sant AJ.
Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins.
Vaccine. 31(1):218-25
2013
Yang H, Topham DJ, Holden-Wiltse J, Wu H.
Statistical Estimation & Inference of Cell Counts form ELISPOT Limiting Dilution Assays.
J Biopharm Stat [In press]
2012 Oct 15
Leddon SA, Sant AJ.
The Peptide specificity of the endogenous T follicular helper cell repertoire generated after protein immunization.
PLoS One. 7(10):46952
2012 Oct 7
Hamilton BS, Sun X, Chung C, Whittaker GR.
Acquisition of a novel eleven amino acid insertion directly N-terminal to a tetrabasic cleavage site confers intracellular cleavage of an H7N7 influenza virus hemagglutinin.
Virology. pii: S0042-6822(12)--445-X
2012 Oct 3
Perez JT, Zlatev I, Aggarwal S, Subramanian S, Sachidanandam R, Kim B, Manoharan M, Tenoever BR.
A Small RNA Enhancer of Viral Polymerase Activity.
J Virol. 86(24):13475-85
2012 Oct 1
Costello DA, Lee DW, Drewes J, Vasquez KA, Kisler K, Wiesner U, Pollack L, Whittaker GR, Daniel S.
Influenza virus-membrane fusion triggered by proton uncaging for single particle studies of fusion kinetics.
Anal Chem. 84(20):8480-9
2012 Aug
Nayak JL, Sant AJ.
Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host.
Immunology. 136(4):425-36
2012 Jul 30
Sant AJ, McMichael A.
Revealing the role of CD4(+) T cells in viral immunity.
J Exp Med. 209(8):1391-5
2012 Jul 28
Noble E, Cox A, Deval J, Kim B.
Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase.
Virology. 433(1):27-34
2012 Jul 24
Hamilton BS, Whittaker GR, Daniel S.
Influenza virus-mediated membrane fusion: determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion.
Viruses. 4(7):1144-68
2012 Jul 18
Hamilton BS, Gludish DW, Whittaker GR.
Cleavage Activation of the Human-Adapted Influenza Virus Subtypes by Matriptase Reveals both Subtype and Strain Specificities.
J Virol. 86(19):10579-86
2012 May 15
Santiago FW, Lambert Emo K, Fitzgerald T, Treanor JJ, Topham DJ.
Antigenic and immunogenic properties of recombinant hemagglutinin proteins from H1N1 A/Brisbane/59/07 and B/Florida/04/06 when produced in various protein expression systems.
Vaccine. 30(31):4606-16
2012 May 1
Chaves FA, Lee AH, Nayak JL, Richards KA, Sant AJ.
The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection.
J Immunol. 188(9):4235-48
2012 Apr 30
Li X, Miao H, Henn A, Topham DJ, Wu H, Zand MS, Mosmann TR.
Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination.
Vaccine. 30(31):4581-4
2012 Apr 25
MacDonald LA, Aggarwal S, Bussey KA, Desmet EA, Kim B, Takimoto T.
Molecular interactions and trafficking of influenza A virus polymerase proteins analyzed by specific monoclonal antibodies.
Virology. 426(1):51-9
2012 Mar 23
Sundararajan A, Huan L, Richards KA, Marcelin G, Alam S, Joo H, Yang H, Webby RJ, Topham DJ, Sant AJ.
Host difference in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization.
PLoS One. 7(3):e34377
2012 Mar 7
Noronha JM, Liu M, Squires RB, Pickett BE, Hale BG, Air GM, Galloway SE, Takimoto T, Schmolke M, Hunt V, Klem E, García-Sastre A, McGee M, Scheuermann RH.
Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction.
J Virol. 86(10):5857-66
2011 Oct 7
Aggerwal S, Dewhurst S, Takimoto T, Kim B.
Biochemical impact of the host adaptation associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex.
J Biol Chem. 286(40):34504-13
2011 Oct 5
Alam S, Sant AJ.
Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus.
J Virol. 85(24):13310-21
2011 Sep 28
Santiago FW, Fitzgerald T, Treanor JJ, Topham DJ.
Vaccination with drifted variants of avian H5 hemagglutinin protein elicits a broadened antibody response that is protective against challenge with homologous or drifted live H5 influenza virus.
Vaccine. 29(48):8888-97
2011 Jun 29
Bradel-Tretheway BG, Mattiacio JL, Krasnoselsky A, Stevenson C, Dewhurst S, Katze MG.
Comprehensive Proteomic Analysis of Influenza Virus Polymerase Complex Reveals a Novel Association with Mitochondrial Proteins and RNA Polymerase Accessory Factors.
J Virol. 85(17)8569-81
2011 May 27
Chapman TJ, Lambert K, Topham DJ.
Rapid Reactivation of Extralymphoid CD4 T cells During Secondary Infection.
PLoS One. 6(5):e20493
2011 May 11
Bussey KA, Desmet EA, Mattiacio JL, Hamilton A, Bradel-Tretheway B, Bussey HE, Kim B, Dewhurst S, Takimoto T.
PA residues in the 2009 H1N1 pandemic influenza virus enhance avian virus polymerase
activity in mammalian cells.
J Virol. 85(14):7020-8
2011 May 9
Noble E, Mathews DH, Chen JL, Turner DH, Takimoto T, Kim B.
Biophysical analysis of influenza A virus RNA promoter at physiological temperatures.
J Biol Chem. 286(26):22965-70
2011 Mar 29
Richards KA, Chaves FA, Sant AJ.
The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity.
Immunology.133(2):246-56
2011 Mar
Nayak JL, Sant AJ.
T cell Immunology for the clinician.
Pediatric Infectious Diseases. 30:248-50
2011 Jan 4
Scheible K, Zhang G, Baer J, Azadniv M, Lambert K, Pryhuber G,
Treanor JJ, Topham DJ.
CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses.
Vaccine. 29(11):2159-68
2010 Oct 27
Guo H, Santiago F, Lambert K, Takimoto T, Topham DJ.
T cell mediated protection against lethal 2009 pandemic H1N1 influenza infection in a mouse model.
J Virol. 85(1):448-55
2010 Oct 1
Richards KA., Topham DT, Chaves FA, Sant AJ
Cutting edge: CD4 T cells generated from encounter with the seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus.
J. Immunol. 185(9):4998-5002
2010 Jun 16
Sun X, Tse LV, Ferguson AD, Whittaker GR.
Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virus.
J Virol. 84(17):8683-90
2010 Apr 29
Aggarwal S, Bradel-Tretheway B, Takimoto T, Dewhurst S, Kim B.
Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex.
PLoS One. 5(4):e10372
2010 Apr
Nayak JL, Richards KA, Chaves FA, Sant AJ.
Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins.
Viral Immunol. 23(2):169-80
2010 Mar 3
Chapman TJ, Topham DJ.
Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1.
J Immunol. 184(7):3841-9
2010 Feb 25
Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB.
Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells.
Virology. 400(2):224-32
2010 Feb 24
Bussey KA, Bousse TL, Desmet EA, Kim B, Takimoto T.
PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.
J Virol. 84(9): 4395–406
2009 Dec
Nayak J, Treanor J.
Antiviral treatment and prophylaxis of influenza virus in children.
Pediatric Annals. 38(12):667-74
2009 Nov 21
Baer J, Santiago F, Yang H, Wu H, Holden-Wiltse J, Treanor J, Topham DJ.
B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant.
Vaccine. 28(4):907-15
2009 May 7
Weaver JM, Chaves FA, Sant AJ.
Abortive activation of CD4 T cell responses during competitive priming in vivo.
Proc Natl Acad Sci U S A. 106(21):8647-52
2009 Apr 22
Richards KA, Chaves FA, Sant AJ.
Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus.
J Virol. 83(13):6566-77
2009 Feb 7
Weaver J, Sant AJ.
Understanding the focused CD4 T cell response to antigen and pathogenic organisms.
Immunol Res. 45:123-43
2008 Dec
Bradel-Tretheway BG, Kelley Z, Chakraborty-Sett S, Takimoto T, Kim B, Dewhurst S.
The human H5N1 influenza A virus polymerase complex is active in vitro over a broad range of temperatures, in contrast to the WSN complex, and this property can be attributed to the PB2 subunit.
J Gen Virol. 89(Pt 12):2923-32
2008 Sep 1
Weaver JM, Lazarski CA, Richards KA, Chaves FA, Jenks SA, Menges PR, Sant AJ.
Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design.
J Immunol. 181(5):3039-48
