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Bruce Goldman, M.D.

Professor of Pathology and Laboratory Medicine

Cardiac and Renal Transplant Pathology
Cellular and Molecular Basis of Cardiovascular Disease

URMC Labs
601 Elmwood Ave., Rm G-5264A
Rochester, NY 14642-8626
Tel: (585) 273-3401
Fax: (585) 273-3637

Bruce_Goldman@urmc.rochester.edu

Director of Autopsy pathology and lead pathologist for the cardiac transplant service.

Qualifications and Professional Activities

M.D., Northwestern University Medical School 1980
Pathology Resident, The Mount Sinai Medical Center, New York, NY 1980-84
Certification, American Board of Pathology (AP/CP) 1985

Research Overview

Most recently, Dr. Goldman completed a study of the resuscitation and transplantation of non-beating donor hearts for the American Heart Association. He is working with Dr. C. Platsoucas in investigating the role of T cell receptor expression in Systemic Sclerosis. They have also studied the role of T cells in Abdominal aortic aneurysm, an antigen driven autoimmune disease, and the immunopathogenesis of chronic cardiac graft rejection. Dr. Goldman's AHA grants have involved the growth and proliferation of human fetal cardiac myocytes, and the role of Insulin-like Growth Factor I in human cardiac cells.

Publications

Tuluc M, Brown B, Goldman B. Lethal vertebral artery dissection in pregnancy: a case report and review of the literature. Arch Pathol Lab Med. 2006 Apr;130(4):533-5.

Petre RE, Quaile MP, Wendt K, Houser SR, Wald J, Goldman BI, Margulies KB. Regionally heterogeneous tissue mechanics in cardiac amyloidosis. Amyloid. 2005 Dec;12(4):246-50.

Singhal AK, Abrams JD, Mohara J, Hasz RD, Nathan HM, Fisher CA, Furukawa S, Goldman BI. Potential suitability for transplantation of hearts from human non-heart-beating donors: data review from the Gift of Life Donor Program. J Heart Lung Transplant. 2005 Oct;24(10):1657-64.

Mohara J, Aguilera I, Goldman BI, Fisher CA, Gaughan JP, Libonati JR, Furukawa S, Singhal AK. Effects of nutrient and hemoglobin enriched cell free perfusates upon ex vivo isolated rat heart preparation. ASAIO J. 2005 May-Jun;51(3):288-95.

Gupta D, Piacentino V 3rd, Macha M, Singhal AK, Gaughan JP, McClurken JB, Goldman BI, Fisher CA, Beltramo D, Monacchio J, Eisen HJ, Furukawa S. Effect of older donor age on risk for mortality after heart transplantation. Ann Thorac Surg. 2004 Sep;78(3):890-9.

Wurzel J, Goldman BI. Premature coronary disease in systemic lupus. N Engl J Med. 2004 Apr 8;350(15):1571-5; author reply 1571-5.

Xu B, Sakkas LI, Goldman BI, Jeevanandam V, Gaughan J, Oleszak EL, Platsoucas CD. Identical alpha-chain T-cell receptor transcripts are present on T cells infiltrating coronary arteries of human cardiac allografts with chronic rejection. Cell Immunol. 2003 Oct;225(2):75-90.

Nicolo D, Goldman BI, Monestier M. Reduction of atherosclerosis in low-density lipoprotein receptor-deficient mice by passive administration of antiphospholipid antibody. Arthritis Rheum. 2003 Oct;48(10):2974-8.

Leech SH, Rubin S, Eisen HJ, Mather PJ, Goldman BI, McClurken JB, Furukawa S. Cardiac transplantation across a positive prospective lymphocyte cross-match in sensitized recipients. Clin Transplant. 2003;17 Suppl 9:17-26.

Goldman BI, Wurzel J. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med. 2001 Oct 11;345(15):1131.

Goldman B, Mach A, Wurzel J. Epidermal growth factor promotes a cardiomyoblastic phenotype in human fetal cardiac myocytes. Exp Cell Res. 1996 Nov 1;228(2):237-45.