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Majed Refaai, M.D.

Assistant Professor of Pathology and Laboratory Medicine

Blood Banking & Transfusion Medicine
Hemolitic and Thrombotic Disorders

URMC Labs
601 Elmwood Ave., Rm G-1562
Rochester, NY 14642-8608
Tel: (585) 276-3927
Fax: (585) 273-3003

Majed_Refaai@urmc.rochester.edu

Dr. Refaai's clinical service is in Transfusion Medicine with subspecialty involvement in laboratory coagulation/thrombosis testing.

Qualifications

M.D., Aleppo University School of Medicine, Syria 1993
Resident in Clinical Pathology, Barnes-Jewish Hospital, Washington University 2003-06
Fellow, Transfusion Medicine, Parkland Memorial Hospital, University of Texas Southwestern 2006-07

Research Overview

Dr. Refaai's recent studies have included:

  • The in-vitro effect of ABO anti-bodies on platelet function.
  • The correlation between cancer and tissue factor (TF) plasma concentrations and its role in developing DVT.
  • The relationship between the circulating TF and the cancer tissue concentrations of TF in different types of mouse models.
  • Beriplex phase IIIb drug study for bleeding patients with Warfarin overdose.
  • Beriplex phase IIIb drug study for surgical patients who require a quick reversal of Warfarin.
  • The effect of ABO non-identical blood products transfusion on platelet function (in-vivo).
  • Platelet transfusion in patients with positive heparin-induced thrombocytopenia.
  • Comparison of tissue factor pathway inhibitor (TFPI) concentration and activity in mononuclear cells from normal individuals versus patients with Paroxysmal Nocturnal Hemoglobinuria.
  • Comparison of TFPI concentrations in normal mouse plasma and endothelial cells versus a diabetic mouse model.
  • Analysis of fatty acid ethyl ester (FAEE) concentrations in binge drinking, chronic alcoholics, and postmortem biopsies.

Publications

L. Holland, T. Warkentin, M.A. Refaai, M. Crowther, M.A. Johnston, and R. Sarode. Suboptimal effect of a three factor Prothrombin complex concentrate (Profilnine-SD) in correcting supratherapeutic international normalized ratio due to warfarin overdose. Transfusion. 2009;49:1171-1177.

A.A. Khorana, C.W. Francis, N. Blumberg, E. Culakova, M.A. Refaai, G.H. Lyman. Blood transfusions, thrombosis and mortality in hospitalized cancer patients. Arch Intern Med. 2008;168:2377-2381.

T. O’Keeffe, M.A. Refaai, K. Tchorz, J.E. Forestner, R. Sarode. A massive transfusion protocol to decrease blood component use and costs. Arch Surg. 2008;143:686-691.

M.A. Refaai. "A primer on antiphospholipid syndrome” Review. ASCP - Check Sample. 2008;51:57-69.

M.A. Refaai, T.E. Warkentin, M. Axelson, K. Matevosyan, R. Sarode. Delayed-onset heparin-induced thrombocytopenia, venous thromboembolism, and cerebral venous thrombosis: a consequence of heparin "flushes". Thromb Haemost. 2007;98:1139-1140.

Refaai MA, Ahn C, Lu L, Wu K, Broze GJ Jr. Protein Z and ZPI levels and cardiovascular events.
J Thromb Haemost. 2006 Jul;4(7):1628-9.

Refaai MA, Van Coot EM, Lukoszyk M, Hughes J, Eby CS. Loss of factor VIII and von Willebrand factor activities during cold storage of whole blood is reversed by rewarming. Lab Hematol. 2006;12(2):99-102.

Refaai MA, Lukoszyk M, Hughes J, Eby CS, Van Cott EM. Cold-dependent loss of factor VIII von Willebrand factor activities in citrated whole blood is reversed by rewarming. Am J Clin Pathol. 2005 Dec;124(6):972; author reply 973.

Refaai MA, Wright RW, Parvin CA, Gronowski AM, Scott MG, Eby CS. Ischemia-modified albumin increases after skeletal muscle ischemia during arthroscopic knee surgery. Clin Chim Acta. 2006 Apr;366(1-2):264-8. Epub 2005 Dec 7.

Refaai MA, Nguyen PN, Cluette-Brown JE, Laposata M. Ethyl arachidonate is the predominant fatty acid ethyl ester in the brains of alcohol-intoxicated subjects at autopsy. Lipids. 2003 Mar;38(3):269-73.

Refaai MA, Van Cott EM, Laposata M. The timing of a positive test result for heparin-induced thrombocytopenia relative to the platelet count and anticoagulant therapy in 43 consecutive cases. Am J Clin Pathol. 2003 Apr;119(4):497-504.

Refaai MA, Laposata M, Van Cott EM. Clinical significance of a borderline titer in a negative ELISA test for heparin-induced thrombocytopenia. Am J Clin Pathol. 2003 Jan;119(1):61-5.

Laposata M, Hasaba A, Best CA, Yoerger DM, McQuillan BM, Salem RO, Refaai MA, Soderberg BL. Fatty acid ethyl esters: recent observations. Prostaglandins Leukot Essent Fatty Acids. 2002 Aug-Sep;67(2-3):193-6. Review.

Refaai MA, Nguyen PN, Steffensen TS, Evans RJ, Cluette-Brown JE, Laposata M. Liver and adipose tissue fatty acid ethyl esters obtained at autopsy are postmortem markers for premortem ethanol intake. Clin Chem. 2002 Jan;48(1):77-83.

Salem RO, Refaai MA, Cluette-Brown JE, Russo JW, Laposata M. Fatty acid ethyl esters in liver and adipose tissues as postmortem markers for ethanol intake. Clin Chem. 2001 Apr;47(4):722-5.

Laposata M, Kabakibi A, Walden MP, Cluette-Brown JE, Nanji AA, Refaai MA, Werner J, Nanji AA. Differences in the fatty acid composition of fatty acid ethyl esters in organs and their secretions. Alcohol Clin Exp Res. 2000 Oct;24(10):1488-91.