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Myra Coppage, Ph.D.

Assistant Professor of Pathology and Laboratory Medicine

Tissue Typing

URMC Labs
601 Elmwood Ave., Rm 2-3657
Rochester, NY 14642-8608
Tel: (585) 275-6352
Fax: (585) 275-2436

Myra_Coppage@urmc.rochester.edu

Dr. Coppage is Director of the HLA/Tissue Typing laboratory, which provides compatibility testing for the solid organ and tissue transplantation services including HLA typing, antibody screening and identification, and crossmatching

Qualifications

Ph.D., Pathology, University of Rochester 2005

High Complexity Lab Director, American Board of Bioanalysis, 2006

Professional Activities

Abstract reviewer, American Transplant Congress 2009

Commissioner, Accreditation Review Board, ASHI 2008

SMH Donor Council 2007

Member, American Society of Transplantation 2006

Member, American Association of Bioanalysis 2006

URMC Organ Procurement Program Advisory Board 1997
United Network for Organ Sharing, Region 9 Histocompatibility representative 1997-1999

Member, American Society for Histocompatibility and Immunogenetics 1986

Research Overview

Dr. Coppage's research focuses on B cells and antibodies involved in organ rejection--how they are produced, what effects they have, and what tests can be used to identify them. She also has interests in immune effects of chemotherapeutic agents and immune reconstitution following stem cell transplantation.  She has authored a number of research articles, presented scientific at annual scientific meetings and is very active in the field of histocompatibility and immunogenetics.

Publications

Leffell M, Fuchs E, Cao K, Coppage M, Hansen J, Hart J, Pereira N, Pereira S, Reinsmoen NL, Senitzer D, Smith A, Torres M, and Vega R.  Incidence of Humoral Sensitization in Partially Mismatched Hematopoietic Stem Cell Transplantation. Submitted, Tissue Antigens 2009.

Coppage M,  Baker M, Fialkow B, Meehan D, Gettings K, Chen L, Massey, T, Blumberg N.  Abrogation of HLA allosensitization in ventricular assist device recipients transfused with leukoreduced, ABO identical blood products. Human Immunology. 2009 June;70(6):413-6.

Blackley S, Kou Z, Chen H, Quinn M, Rose RC, Schlesinger JJ, Coppage M, Jin X.  Primary human splenic macrophages, but not T or B cells, are the principal target cells for dengue virus infection in vitro. J Virol.2007 Dec;81(24): 13325-34. 

Coppage M, Belanger T, Zauderer M, Sahasrabudhe D. In vitro generation of tumor specific T cells that recognize a shared antigen of AML: molecular characterization of TCR genes. Leuk Res. 2007 Feb;31(2):195-202. Epub 2006 Jun 5.

Zand MS, Bose A, Vo T, Coppage M, Pellegrin T, Arend L, Lee FE, Bozorgzadeh A, Leong N. A renewable source of donor cells for repetitive monitoring of T- and B-cell alloreactivity. Am J Transplant. 2005 Jan;5(1):76-86.

Shah A, Nadasdy T, Arend L, Brennan J, Leong N, Coppage M, Orloff M, Demme R, Zand MS. Treatment of C4d-positive acute humoral rejection with plasmapheresis and rabbit polyclonal antithymocyte globulin. Transplantation. 2004 May 15;77(9):1399-405.

Sayeed S, Cullen JP, Coppage M, Sitzmann JV, Redmond EM. Ethanol differentially modulates the expression and activity of cell cycle regulatory proteins in rat aortic smooth muscle cells. Eur J Pharmacol. 2002 Jun 12;445(3):163-70.

Brayman AA, Coppage ML, Vaidya S, Miller MW. Transient poration and cell surface receptor removal from human lymphocytes in vitro by 1 MHz ultrasound. Ultrasound Med Biol. 1999 Jul;25(6):999-1008.

Blom D, Morrissey NJ, Mesonero C, Coppage M, Fisher T, Zuo XJ, Jordan SC, Orloff MS. Induction of specific tolerance through mixed hematopoietic chimerism prevents chronic renal allograft rejection in a rat model. Surgery. 1996 Aug;120(2):213-9; discussion 219-20.

Orloff MS, DeMara EM, Coppage ML, Leong N, Zuo XJ, Prehn J, Jordan SC. Alterations of the interleukin-4 pathway in production of tolerance by mixed hematopoietic chimerism. Surgery. 1995 Aug;118(2):212-9.

Orloff MS, DeMara EM, Coppage ML, Leong N, Fallon MA, Sickel J, Zuo XJ, Prehn J, Jordan SC. Prevention of chronic rejection and graft arteriosclerosis by tolerance induction. Transplantation. 1995 Jan 27;59(2):282-8.

Orloff MS, Fallon MA, DeMara E, Coppage ML, Leong N, Cerilli J. Induction of specific tolerance to small-bowel allografts. Surgery. 1994 Aug;116(2):222-8.

Doran M, Coppage M, Ruth J, Fish J, Winsett O, Vaidya S. Renal allograft survival in highly sensitized patients treated with cyclosporine. Transplant Proc. 1987 Feb;19(1 Pt 3):1988. No abstract available.

Gifford RR, Doran MM, Ruth JA, Coppage ML, Winsett OE, Fish JC. Positive antiglobulin cytotoxicity crossmatch in renal allograft recipients treated with cyclosporine. Transplantation. 1986 Oct;42(4):439-41. No abstract available.