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Philip Katzman, M.D.

Assistant Professor of Pathology and Laboratory Medicine

Surgical Pathology, Pediatric Pathology
Placental and Developmental Disorders

URMC Labs
601 Elmwood Ave., Rm G-5247
Rochester, NY 14642-8626
Tel: (585) 273-4091
Fax: (585) 273-3637

Philip_Katzman@urmc.rochester.edu

Dr. Katzman's primary clinical interests are in pediatric developmental and oncological diseases, and placental pathology. He is coordinator for the Antenatal and Postnatal Pediatric Pathology residency rotations.

Qualifications

M.D., University of Vermont College of Medicine 1992
Pediatric Residency, University of Rochester 1992-94
Pathology Residency, University of Rochester 1995-98
Fellow, Pediatric Pathology, Children's Hospital Boston 1998-2000
Board Certification, American Board of Pathology (AP/CP) 1998
American Board of Pathology (Pediatric Pathology) 1999

Research Overview

Dr. Katzman's research interests include placental pathology and development disorders, such as DiGeorge syndrome. He has begun investigating the ability to confirm morphologically diagnosed hydatidiform moles using fluorescent in situ hybridization (FISH) in cases where cytogenetic analysis on submitted tissue is unhelpful (no growth) or cannot be processed due to fixation. FISH could become an alternative diagnostic method for these specimens in our clinical laboratory. Dr. Katzman has also investigated the enigmatic "maternal floor infarction" in the placenta and is particularly interested in its identification as a possible etiology in recurrent first trimester losses.

Dr. Katzman developed an interest in DiGeorge syndrome and the deletion 22q11.2 spectrum while in pediatric pathology fellowship. He has studied a cohort of autopsied patients with congenital heart disease compiled in the Cardiac Registry of Boston Children's Hospital to identify a subpopulation with the 22q11.2 deletion. He used the polymerase chain reaction (PCR) to evaluate loss of heterozygosity (LOH) in this chromosome region for each patient. He hopes to confirm his data by performing FISH on the same cases and to develop a PCR assay for the 22q11.2 deletion as an alternative to the currently used clinical FISH assay.

Publications

Katzman PJ, Spitalnik SL, Metlay LA.Multidisciplinary Pediatric Pathology Rotations in a Residency Training Program.Pediatr Dev Pathol. 2003 Mar 28. PubMed Publication List

Katzman PJ, Genest DR. Maternal floor infarction and massive perivillous fibrin deposition: histological definitions, association with intrauterine fetal growth restriction, and risk of recurrence. Pediatr Dev Pathol. 2002 Mar-Apr;5(2):159-64. PubMed Publication List

Hendrickson RJ, Katzman PJ, Queiroz R, Sitzmann JV, Koniaris LG. Management of massive retroperitoneal hemorrhage from an adrenal tumor. Endocr J 2001 Dec;48(6):691-6 PubMed Publication List

Funkhouser AW, Katzman PJ, Sickel JZ, Lambert JS. CD30-positive anaplastic large cell lymphoma (ALCL) of T-cell lineage in a 14-month-old infant with perinatally acquired HIV-1 infection. J Pediatr Hematol Oncol 1998 Nov-Dec;20(6):556-9 PubMed Publication List

Katzman PJ, Arnold GL. Propionic acidemia presenting as pyloric stenosis. Clin Pediatr (Phila) 1995 Nov;34(11):613-5 PubMed Publication List

Higgins JC, Katzman PJ, Yeager SB, Dickerman JD, Leavitt BJ, Tischler MD, Battle RW. Extraskeletal Ewing's sarcoma of primary cardiac origin. Pediatr Cardiol 1994 Jul-Aug;15(4):207-8 PubMed Publication List

Carroll MC, Alicot EM, Katzman PJ, Klickstein LB, Smith JA, Fearon DT. Organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4-binding protein in the RCA locus on human chromosome 1. J Exp Med 1988 Apr 1;167(4):1271-80 PubMed Publication List

Carroll MC, Katzman P, Alicot EM, Koller BH, Geraghty DE, Orr HT, Strominger JL, Spies T. Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes. Proc Natl Acad Sci U S A 1987 Dec;84(23):8535-9 PubMed Publication List