Department of Pediatrics - O'Reilly Lab

Publications

Selected Journal Articles

Giannandrea M, Yee M, O’Reilly MA, and Lawrence, BP. "Memory CD8+ T cells are sufficient to alleviate impaired host resistance to influenza A virus infection caused by neonatal oxygen supplementation." Clinical and Vaccine Immunology. 19: 1432-1441, 2012.

Buczynski BW; Yee M; Lawrence BP; O'Reilly MA. "Lung development and the host response to influenza A virus are altered by different doses of neonatal oxygen in mice." American Journal of Physiology. Lung Cellular and Molecular Physiology. 2012; 302(10):L1078-87. Epub 2012 Mar 09.

O'Reilly MA; Yee M; Buczynski BW; Vitiello PF; Keng PC; Welle SL; Finkelstein N; Dean DA; Lawrence BP. "Neonatal oxygen increases sensitivity to influenza A virus infection in adult mice by suppressing epithelial expression of Ear1."
The American Journal of Pathology. 2012; 181(2):441-51. Epub 2012 Jun 05.

O'Reilly MA.
"Angiotensin II: tapping the cell cycle machinery to kill endothelial cells." American Journal of Physiology. Lung Cellular and Molecular Physiology. 2012; Epub 2012 Aug 10.

Gewandter JS; Bambara RA; O'Reilly MA. "The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA." Cell cycle (Georgetown, Tex.). 2011; 10(15):2561-7. Epub 2011 Aug 01.

Yee M; White RJ; Awad HA; Bates WA; McGrath-Morrow SA; O'Reilly MA. "Neonatal hyperoxia causes pulmonary vascular disease and shortens life span in aging mice."
The American Journal of Pathology. 2011; 178(6):2601-10. Epub 2011 May 06.

Wu YC; O'Reilly MA. "Bcl-X(L) is the primary mediator of p21 protection against hyperoxia-induced cell death." Experimental Lung Research. 2011; 37(2):82-91. Epub 2010 Dec 04.

Staversky RJ, Vitiello PF, Yee M, Dean DA, and O'Reilly MA. "Epithelial ablation of Bcl-XL increases sensitivity to hyperoxia without disrupting lung development." American Journal of Respiratory Cell and Molecular Biology, In press. 2010;.

Chess PR; Benson RP; Maniscalco WM; Wright TW; O'Reilly MA; Johnston CJ. "Murine mechanical ventilation stimulates alveolar epithelial cell proliferation."
Experimental Lung Research. 2010; 36(6):331-41.

Staversky RJ; Vitiello PF; Yee M; Callahan LM; Dean DA; O'Reilly MA. "Epithelial ablation of Bcl-XL increases sensitivity to oxygen without disrupting lung development."
American Journal of Respiratory Cell and Molecular Biology. 2010; 43(3):376-85. Epub 2009 Oct 30.

McGrath-Morrow S, Lauer T, Yee M, Neptune E, Podowski M, Thimmulappa RK, O'Reilly MA, and Biswal S. "Nrf2 increases survival and attentuates alveolar growth inhibition in neonatal mice exposed to hyperoxia." American Journal of Physiology. Lung Cellular and Molecular Physiology. 2009; 40: L565-573.

Yee M, Chess PR, McGrath-morrow SA, Wang Z, Gelein R, Zhou R, Dean DA, Notter RH, and O'Reilly MA. "Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition of activity." American Journal of Physiology. Lung Cellular and Molecular Physiology. 2009; 297: L641 - L649.

Gewandter JS, Staversky RJ, and O'Reilly MA. "Hyperoxia augments UPR induced cell death independent of BiP loss." Free Radical Biology and Medicine. 2009; 47: 1742 - 1752.

Gewandter JS; Staversky RJ; O'Reilly MA. "Hyperoxia augments ER-stress-induced cell death independent of BiP loss."
Free Radical Biology & Medicine. 2009; 47(12):1742-52. Epub 2009 Sep 26.

Vitiello PF; Wu YC; Staversky RJ; O'Reilly MA. "p21(Cip1) protects against oxidative stress by suppressing ER-dependent activation of mitochondrial death pathways."
Free Radical Biology & Medicine. 2009; 46(1):33-41. Epub 2008 Oct 07.

Lew BJ; Collins LL; O'Reilly MA; Lawrence BP. "Activation of the aryl hydrocarbon receptor during different critical windows in pregnancy alters mammary epithelial cell proliferation and differentiation." Toxicological sciences: an official journal of the Society of Toxicology. 2009; 111(1):151-62. Epub 2009 Jun 05.

Yee M; Chess PR; McGrath-Morrow SA; Wang Z; Gelein R; Zhou R; Dean DA; Notter RH; O'Reilly MA.
"Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity."
American Journal of Physiology. Lung Cellular and Molecular Physiology. 2009; 297(4):L641-9. Epub 2009 Jul 17.

Pryhuber, G.S.; Huyck, H.L.; Bhagwat, S.; O'Reilly, M.A.; Finkelstein, J.N.; Gigliotti, F.; and Wright, T.W. "Parenchymal cell tumor necrosis factor receptors contribute to inflammatory cell recruitment and respiratory failure in pneumocystis carinii induced pneumonia." Journal of Immunology. 2008; 81: 1409 - 1419.

Vitiello PF; Staversky RJ; Keng PC; O'Reilly MA. "PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax death."
Free Radical Biology & Medicine. 2008; 44(3):367-74. Epub 2007 Oct 10.

O'Reilly MA; Marr SH; Yee M; McGrath-Morrow SA; Lawrence BP. "Neonatal hyperoxia enhances the inflammatory response in adult mice infected with influenza A virus."
American journal of respiratory and critical care medicine. 2008; 177(10):1103-10. Epub 2008 Feb 21.

Yao H; Yang SR; Edirisinghe I; Rajendrasozhan S; Caito S; Adenuga D; O'Reilly MA; Rahman I. "Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice." American journal of respiratory cell and molecular biology. 2008; 39(1):7-18. Epub 2008 Jan 31.

Gehen SC; Staversky RJ; Bambara RA; Keng PC; O'Reilly MA. "hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress."
Oncogene. 2008; 27(29):4065-74. Epub 2008 Mar 10.

Pryhuber GS; Huyck HL; Bhagwat S; O'Reilly MA; Finkelstein JN; Gigliotti F; Wright TW. "Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia." Journal of Immunology (Baltimore, Md. : 1950). 2008; 181(2):1409-19.

Bijli KM; Minhajuddin M; Fazal F; O'Reilly MA; Platanias LC; Rahman A. "c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells." American Journal of Physiology. Lung Cellular and Molecular Physiology. 2007; 292(2):L396-404. Epub 2006 Sep 29.

Gehen SC; Vitiello PF; Bambara RA; Keng PC; O'Reilly MA. "Downregulation of PCNA potentiates p21-mediated growth inhibition in response to hyperoxia."
American Journal of Physiology. Lung Cellular and Molecular Physiology. 2007; 292(3):L716-24. Epub 2006 Nov 03.

Auten RL; O'Reilly MA; Oury TD; Nozik-Grayck E; Whorton MH. "Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia." American Journal of Physiology. Lung Cellular and Molecular Physiology. 2006; 290(1):L32-40. Epub 2005 Aug 12.