Infectious Diseases Research

Investigators

Research Interests:

Publications:

Bruckner L, Gigliotti F, Wright T, Notter RH, Chess P, Wang Z, Finkelstein J. Pneumocystis carinii infection sensitizes the lung to radiation-induced injury after syngeneic marrow transplantation: Role of CD4+ T cells. Am J Physiol Lung Cell Mol Physiol 2006;290(6):L1087-96.
Wells J, Haidaris CG, Wright TW, Gigliotti F. Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia. Infect Immun 2006;74(1):390-3.
Bhagwat SP, Gigliotti F, Xu H, Wright TW. Contribution of T cell subsets to the pathophysiology of Pneumocystis-related immunorestitution disease. Am J Physiol Lung Cell Mol Physiol 2006;291:L1256-66.
Gigliotti F, Crow EL, Bhagwat SP, Wright TW. Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia. Infect Immun 2006;74:6310-16.

Research Interests:

Research Interests:

Publications:

Caserta MT, Mock DJ, Dewhurst S. Human Herpesvirus 6.
Clin Infect Dis 2001;33:829-833.
Hall CB, Caserta MT, Schnabel KC, Boettrich C, McDermott MP, Lofthus GK, Carnahan JA, Dewhurst S. Congenital infections with human herpesviruses 6 and 7. J Pediatr 2004;145:472-7.
Caserta MT, McDermott MP, Dewhurst S, Schnabel K, Carnahan J, Gilbert L, Lathan G, Lofthus GK, Hall CB. Human Herpesvirus 6 (HHV6) DNA persistence and reactivation in normal children. J Pediatr 2004;145:478-84.

Research Interests:

Publications:

Christy C, Aligne CA, Auinger P, Pulcino T, Weitzman M. Lack of effect of influenza vaccine for prevention of asthma exacerbations.
Arch Dis Child 2004;89:734-35.
Garfunkel LC, Kaczorowski J, Christy C (editors). The Pediatric Clinical Advisor. Mosby-Year Book, Inc., St. Louis, MO (2001).

Research Interests:

Pathogenesis and outcome of human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7) infection
The epidemiologic and clinical characteristics of respiratory viruses
Immunization and prevention strategies

Publications:

Hall CB, Caserta MT, Schnabel KC, Boettrich C, McDermott MP, Lofthus GK, Carnahan JA, Dewhurst S. Congenital infections with human herpesviruses 6 and 7. J Pediatr 2004;145(4):472-77.
Hall CB, Weinberg GA, Copeland J, Edwards KM, Iwane MK, Staat MA, Griffin MR, Morrow AL, Erdman DD, Szilagyi PG. Respiratory syncytial virus (RSV) infection in young children: New population-based estimates of hospitalization and outpatient visit rates.
PAS Abstract (submitted December 7, 2004).
Meissner HC, Rennels MB, Pickering LK, Hall CB. Risk of severe RSV diseases, identification of high-risk infants and recommendations for prophylaxis with palivizumab. Pediatr Infect Dis J 2004;23(3):284-5.

Research Interests:

Yeast Aspartyl Proteases in Cell Wall Integrity: Investigating the role of a family of aspartyl proteases in yeast cell wall biosynthesis using a variety of biochemical, genetic and cell biological approaches
Development of High Throughput Assay for Cell Wall-Targeted Antifungal Drugs: Developing assays to identify small molecules that disrupt cell wall biosynthesis by detecting cell lysis and activation of cell wall integrity stress response pathways

Publications:

Krysan DJ, Gilsdorf JR. Clinical research abstracts for pediatricians: Effectiveness of inactivated influenza vaccine in preventing acute otitis media in young children. J Pediatr 2004;144:406.
Krysan DJ. Best Clinical Evidence Section: Effectiveness over time of varicella vaccination. J Pediatr 2002;145:416.

Research Interests:

Publications:

Weinberg GA, Erdman DD, Edwards KM, Hall CB, Walker FJ, Griffin MR, Schwartz B, and the New Vaccine Surveillance Network Study Group. Superiority of reverse-transcription polymerase chain reaction to conventional viral culture in the diagnosis of acute respiratory tract infections in children.
J Infect Dis 2004;189:706-10.
Griffin MR, Walker FJ, Iwane MK, Weinberg GA, Staat MA, Erdman DD, and the NVSN Study Group. Epidemiology of respiratory infections in young children: Insights from the New Vaccine Surveillance Network (NVSN).
Pediatr Infect Dis J 2004;23:S188-S92.
Weinberg GA, Burchett SL. Pediatric human immunodeficiency virus (HIV) infection. In: Mandell GL, Bennett JE, Dolin R (eds). Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases, 6th Edition. Philadelphia: Elsevier, 2005, pp. 1638-54.

Research Interets:

Publications:

Wellington M, Bliss JM, Haidaris CG. Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment. Infect Immun 2003;71(12):7228-31.
Bliss JM, Wellington M, Gigliotti F. Antifungal therapy for neonatal candidiasis. Sem Perinatol 2003;27(5):365-84.

Research Interests:

Publications:

Wells J, Haidaris CG, Wright TW, Gigliotti F. Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen. Infect Immun 2006;74(4):2446-8.
Bruckner L, Gigliotti F, Wright T, Notter RH, Chess P, Wang Z, Finkelstein J. Pneumocystis carinii infection sensitizes the lung to radiation-induced injury after syngeneic marrow transplantation: Role of CD4+ T cells. Am J Physiol Lung Cell Mol Physiol 2006;290(6):L1087-96.
Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O’Reilly MA. P21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth. Am J Pathol 2006;168(6):1838-47.
Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco M, Finkelstein JN, O’Reilly MA. Type II epithelial cells are a critical target for hyperoxia mediated impairment of postnatal lung development. Am Physiol Lung Cell Mol Physiol 2006; in press; [Epub ahead of print].