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URMC » Pediatrics » Training » Fellowship » Programs » Pulmonology

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Pulmonology Fellowship

Fellowship Research

Epidemiologic Study of Cystic Fibrosis (ESCF). The ESCF is a multi-center longitudinal cohort study of CF patients in North America. The data used to describe practice patterns and outcomes in CF care. Current analyses include the relationship between inhaled corticosteroid therapy and lung function decline and the effect of methicillin resistant S. aureus acquisition on lung function.

Measurement of Lung Function using Respiratory Inductive Plethsymography in Infants with Viral Bronchiolitis. The goal of this study is to apply a non-invasive technique of pulmonary function testing called respiratory inductive plethysmography (IP) to assess changes in lung function over time and in response to therapies in infants with viral bronchiolitis.

Lung Function and Immune Response in RSV Bronchiolitis. The objective of this project is to study the relationship between TH2 cytokine production and lung function in infants with RSV bronchiolitis. Lung function will be assessed using the raised volume/rapid thoracoabdominal compression technique.

Lung Function Measures in Preschool Children with Cystic Fibrosis. The purpose of this study is to compare 3 methods of pulmonary function testing in preschool aged children with CF. The 3 methods are modified spirometry, Inductive Plethysmography abd forced oscillometry.

Clinical application of quorum sensing signals in Pseudomonas to the treatment of CF lung disease. This project is being conducted in collaboration with Dr. Barbara Iglewski. The purpose of this project is to determine if clinical outcomes correlate with quorum sensing signals and stationary phase antibiotic sensitivities in Pseudomonas species. The microbiologic data will be collated and analyzed. If patterns of antibiotic sensitivity or clinical outcomes are identified, we will then prospectively evaluate their clinical application in the treatment of CF lung disease.

Selected References

• Konstan MW, SM Butler, et al. Patterns of medical practice in cystoic fibrosis: part II. Use of therapies. Investigators and coordinators of the Epidemiologic Study of Cystic Fibrosis. Pediatr Pulmonol 1999;28:242-247.
• Ren CL, Pasta DJ, Konstan MW, Wagener JS, Morgan WJ. Inhaled corticosteroid use is associated with a slower rate of decline in FEV1 in CF patients. Pediatr Pulmonol 2003 S25; 294.
• Ren, CL, J.L. Brucker, A.K. Rovitella, and K.A. Bordeaux. Changes in lung function measured by spirometry and the forced oscillation technique in CF patients undergoing treatment for respiratory tract exacerbation. 2006. Pediatr Pulmonol 41:345-349.
• DeKievit TR, Iglewski BH. Bacterial quorum sensing in pathogenic relationships. Infect Immun 2000;68:4839-4849.

 

Pulmonology

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