Jacob N. Finkelstein, Ph.D.

Jacob N. Finkelstein, Ph.D.

Contact Information

University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave., Box 850
Rochester, NY 14642

Office: (585) 275-5948

Research Bio

Dr. Finkelstein's laboratory research emphasizes the role of the alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli. This includes studies of oxidant induced signaling in the pulmonary epithelium and macrophages and epithelial production of cytokines and chemokines in the regulation of the inflammatory functions of alveolar macrophages. His previous research effort focused on the pulmonary alveolar type II cell as the site of pulmonary surfactant synthesis and secretion, and studies on the basic cell and molecular biology of these processes are still an important facet of his work. In addition, the type II cell also plays an important role as the stem cell for renewal of the alveolar epithelium both in the normal lung development and during epithelial repair and renewal following lung injury. The most recent data suggest that type II cells may also be involved in regulating the inflammatory functions of alveolar macrophages, as well as the actions of interstitial fibroblasts during lung growth or pulmonary fibrosis.
The overall goal of the current research is to identify some of the key control mechanisms involved in epithelial cell and fibroblast proliferation, and in related extracellular matrix synthesis, processing and assembly. This work seeks to define such mechanisms not only during normal lung growth and normal development, but also during the repair of epithelial damage, and may have important implications for pediatric and adult lung disease, including bronchopulmonary dysplasia (BPD) in premature infants. This work is funded by grants from NIH, EPA and DoD.



The overall goal of some of their additional current research is to identify some of the key control mechanisms involved in epithelial cell and fibroblast proliferation, and in related extracellular matrix synthesis, processing and assembly. This work seeks to define such mechanisms not only during normal lung growth and normal development, but also during the repair of epithelial damage, and may have important implications for pediatric and adult lung disease, including bronchopulmonary dysplasia (BPD) in premature infants.

Awards & Honors (Local)

March of Dimes Health Leadership Award 2006
Elected member, Perinatal Research Society 1986
Sigma Xi Graduate Research Symposium Award 1974

Recent Journal Articles

Showing the 5 most recent journal articles. 186 available »

2014
Allen JL, Liu X, Weston D, Prince L, Oberdörster G, Finkelstein JN, Johnston CJ, Cory-Slechta DA. "Developmental Exposure to Concentrated Ambient Ultrafine Particulate Matter Air Pollution in Mice Results in Persistent and Sex-Dependent Behavioral Neurotoxicity and Glial Activation." Toxicological sciences : an official journal of the Society of Toxicology.. 2014 Epub 2014 Apr 01.
2013
Thach CT, Finkelstein JN. "Cationic nanoparticles disrupt cellular signaling in a cholesterol dependent manner." Toxicology in vitro : an international journal published in association with BIBRA. 2013 27(4):1277-86. Epub 2012 Dec 26.
2013
"Exacerbation of lung radiation injury by viral infection: the role of Clara cells and Clara cell secretory protein." Radiation research.. 2013 179(6):617-29. Epub 2013 Apr 26.
2013
Johnston CJ, Manning CM, Rangel-Moreno J, Randall TD, Hernady E, Finkelstein JN, Williams JP. "Neonatal irradiation sensitizes mice to delayed pulmonary challenge." Radiation research.. 2013 179(4):475-84. Epub 2012 Mar 15.
2013
Fazal F, Bijli KM, Murrill M, Leonard A, Minhajuddin M, Anwar KN, Finkelstein JN, Watterson DM, Rahman A. "Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration." PloS one. 2013 8(3):e59965. Epub 2013 Mar 21.

Current Appointments

Professor - Department of Pediatrics, Neonatology (SMD) - Primary
Professor - Department of Environmental Medicine (SMD)

Education

PhD | Biochemistry | Northwestern University1976
BS | Chemistry | Carnegie-Mellon University1971