Thomas A. Gasiewicz, Ph.D.

Thomas A. Gasiewicz, Ph.D.

Contact Information

University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave., Box EHSC
Rochester, NY 14642

Administrative: (585) 275-6728

Professional Bio

Thomas A. Gasiewicz received his B.S. in Chemistry from Canisius College and went on to study Toxicology at the University of Rochester, where he received his PhD in 1977.

Research Bio

Receptor-mediated Modulation of Gene Expression and Association with Biological and Toxic Responses



While genetics is known to influence the initiation, progression, and outcome of a variety of human diseases including cancer, it is clear that these are also influenced to a great extent by a number of other factors. These include, for example, exposure to chemicals in the environment, diet and aging.

The overall goal of the research in this laboratory is to determine how certain chemicals and substances in the diet influence, in both a positive and negative manner, the processes that influence the progression and outcomes of disease.
By understanding the molecular mechanisms by which these factors act, we will also be providing information that can be used in the design of tools for more effective diagnosis and treatment of these diseases.

Awards & Honors (Local)

Paper of the Year, Immunotoxicology Specialty Section, Society of Toxicology, 2005 2005
Best Paper in Toxicology and Applied Pharmacology, 1998 1999
University of Rochester, School of Medicine, Alumni Award for Excellence in Graduate Education 1998
Visiting Associate Professor, Department of Pharmacology, Stanford University 1989 - 1990
International Life Sciences Institute Research Foundation Award 1987 - 1990
National Institutes of Health Postdoctoral Fellowship Award 1977 - 1980

Recent Journal Articles

Showing the 5 most recent journal articles. 119 available »

2014
Bhat R, Adam AT, Lee JJ, Gasiewicz TA, Henry EC, Rotella DP. "Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors." Bioorganic & medicinal chemistry letters. 2014 24(10):2263-6. Epub 2014 Apr 04.
2014
Gasiewicz TA, Singh KP, Bennett JA. "The Ah receptor in stem cell cycling, regulation, and quiescence." Annals of the New York Academy of Sciences. 2014 1310:44-50. Epub 2014 Feb 03.
2014
Singh KP, Bennett JA, Casado FL, Walrath JL, Welle SL, Gasiewicz TA. "Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic stem cell exhaustion and development of a myeloproliferative disorder in aging mice." Stem cells and development. 2014 23(2):95-106. Epub 2013 Oct 19.
2011
Casado FL, Singh KP, Gasiewicz TA. "Aryl hydrocarbon receptor activation in hematopoietic stem/progenitor cells alters cell function and pathway-specific gene modulation reflecting changes in cellular trafficking and migration." Molecular pharmacology. 2011 80(4):673-82. Epub 2011 Jul 26.
2011
Singh KP, Garrett RW, Casado FL, Gasiewicz TA. "Aryl hydrocarbon receptor-null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions." Stem cells and development. 2011 20(5):769-84. Epub 2010 Nov 09.

Current Appointments

Chair - Department of Environmental Medicine (SMD) - Primary Administrative
Professor - Department of Environmental Medicine (SMD) - Primary

Education

PhD | Toxicology | Univ Rochester Sch Med/Dent1977
BS | Chemistry | Canisius College1972