Thomas A. Gasiewicz, Ph.D.

Thomas A. Gasiewicz, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box EHSC
Rochester, NY 14642

Administrative: (585) 275-6728

Journal Articles

Showing all 119 journal articles available.

2014 May 15
Bhat R, Adam AT, Lee JJ, Gasiewicz TA, Henry EC, Rotella DP. "Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors." Bioorganic & medicinal chemistry letters.. 2014 May 15; 24(10):2263-6. Epub 2014 Apr 04.
2014 Mar
Gasiewicz TA, Singh KP, Bennett JA. "The Ah receptor in stem cell cycling, regulation, and quiescence." Annals of the New York Academy of Sciences.. 2014 Mar; 1310:44-50. Epub 2014 Feb 03.
2014 Jan 15
Singh KP, Bennett JA, Casado FL, Walrath JL, Welle SL, Gasiewicz TA. "Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic stem cell exhaustion and development of a myeloproliferative disorder in aging mice." Stem cells and development.. 2014 Jan 15; 23(2):95-106. Epub 2013 Oct 19.
2011 Oct
Casado FL, Singh KP, Gasiewicz TA. "Aryl hydrocarbon receptor activation in hematopoietic stem/progenitor cells alters cell function and pathway-specific gene modulation reflecting changes in cellular trafficking and migration." Molecular pharmacology.. 2011 Oct; 80(4):673-82. Epub 2011 Jul 26.
2011 May
Singh KP, Garrett RW, Casado FL, Gasiewicz TA. "Aryl hydrocarbon receptor-null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions." Stem cells and development.. 2011 May; 20(5):769-84. Epub 2010 Nov 09.
2011 Feb
Latchney SE, Lioy DT, Henry EC, Gasiewicz TA, Strathmann FG, Mayer-Pröschel M, Opanashuk LA. "Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin." Stem cells and development.. 2011 Feb; 20(2):313-26. Epub 2010 Aug 31.
2010 May
Laiosa MD, Mills JH, Lai ZW, Singh KP, Middleton FA, Gasiewicz TA, Silverstone AE. "Identification of stage-specific gene modulation during early thymocyte development by whole-genome profiling analysis after aryl hydrocarbon receptor activation." Molecular pharmacology.. 2010 May; 77(5):773-83. Epub 2010 Feb 16.
2010 Apr 15
Casado FL, Singh KP, Gasiewicz TA. "The aryl hydrocarbon receptor: regulation of hematopoiesis and involvement in the progression of blood diseases." Blood cells, molecules & diseases.. 2010 Apr 15; 44(4):199-206. Epub 2010 Feb 19.
2010 Mar 19
Gasiewicz TA, Singh KP, Casado FL. "The aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: implications for benzene-induced hematopoietic toxicity." Chemico-biological interactions.. 2010 Mar 19; 184(1-2):246-51. Epub 2009 Nov 05.
2010 Mar
Henry EC, Welle SL, Gasiewicz TA. "TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fibroblasts." Toxicological sciences : an official journal of the Society of Toxicology.. 2010 Mar; 114(1):90-100. Epub 2009 Nov 19.
2009 Feb 15
Singh KP, Casado FL, Opanashuk LA, Gasiewicz TA. "The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations." Biochemical pharmacology.. 2009 Feb 15; 77(4):577-87. Epub 2008 Oct 15.
2009 Jan 20
Yin Z, Henry EC, Gasiewicz TA. "(-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor." Biochemistry.. 2009 Jan 20; 48(2):336-45.
2009 Jan
Singh KP, Wyman A, Casado FL, Garrett RW, Gasiewicz TA. "Treatment of mice with the Ah receptor agonist and human carcinogen dioxin results in altered numbers and function of hematopoietic stem cells." Carcinogenesis.. 2009 Jan; 30(1):11-9. Epub 2008 Sep 26.
2008 Oct 24
Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ. "The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB." The Journal of biological chemistry.. 2008 Oct 24; 283(43):28944-57. Epub 2008 Aug 12.
2008 May
Collins LL, Williamson MA, Thompson BD, Dever DP, Gasiewicz TA, Opanashuk LA. "2,3,7,8-Tetracholorodibenzo-p-dioxin exposure disrupts granule neuron precursor maturation in the developing mouse cerebellum." Toxicological sciences : an official journal of the Society of Toxicology.. 2008 May; 103(1):125-36. Epub 2008 Jan 27.
2008 Apr 15
Henry EC, Gasiewicz TA. "Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor." Archives of biochemistry and biophysics.. 2008 Apr 15; 472(2):77-88. Epub 2008 Feb 13.
2008
Gasiewicz TA, Henry EC, Collins LL. "Expression and activity of aryl hydrocarbon receptors in development and cancer." Critical reviews in eukaryotic gene expression.. 2008 18(4):279-321.
2008
Vezina CM, Allgeier SH, Moore RW, Lin TM, Bemis JC, Hardin HA, Gasiewicz TA, Peterson RE. "Dioxin causes ventral prostate agenesis by disrupting dorsoventral patterning in developing mouse prostate." Toxicological sciences : an official journal of the Society of Toxicology.. 2008 106(2):488-96. Epub 2008 Sep 08.
2007 Oct
Ryan EP, Holz JD, Mulcahey M, Sheu TJ, Gasiewicz TA, Puzas JE. "Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2007 Oct; 22(10):1571-80.
2007 Mar
Thatcher TH, Maggirwar SB, Baglole CJ, Lakatos HF, Gasiewicz TA, Phipps RP, Sime PJ. "Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB." The American journal of pathology.. 2007 Mar; 170(3):855-64.
2007 Jan
Bemis JC, Alejandro NF, Nazarenko DA, Brooks AI, Baggs RB, Gasiewicz TA. "TCDD-induced alterations in gene expression profiles of the developing mouse paw do not influence morphological differentiation of this potential target tissue." Toxicological sciences : an official journal of the Society of Toxicology.. 2007 Jan; 95(1):240-8. Epub 2006 Oct 11.
2006 Jun 1
Henry EC, Bemis JC, Henry O, Kende AS, Gasiewicz TA. "A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo." Archives of biochemistry and biophysics.. 2006 Jun 1; 450(1):67-77. Epub 2006 Mar 03.
2006 Jun
Kim SH, Henry EC, Kim DK, Kim YH, Shin KJ, Han MS, Lee TG, Kang JK, Gasiewicz TA, Ryu SH, Suh PG. "Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor." Molecular pharmacology.. 2006 Jun; 69(6):1871-8. Epub 2006 Mar 15.
2006 Jun
Garrett RW, Gasiewicz TA. "The aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin alters the circadian rhythms, quiescence, and expression of clock genes in murine hematopoietic stem and progenitor cells." Molecular pharmacology.. 2006 Jun; 69(6):2076-83. Epub 2006 Mar 23.
2005 Oct
Bemis JC, Nazarenko DA, Gasiewicz TA. "Coplanar polychlorinated biphenyls activate the aryl hydrocarbon receptor in developing tissues of two TCDD-responsive lacZ mouse lines." Toxicological sciences : an official journal of the Society of Toxicology.. 2005 Oct; 87(2):529-36. Epub 2005 Jul 20.
2005 Sep
Martey CA, Baglole CJ, Gasiewicz TA, Sime PJ, Phipps RP. "The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts." American journal of physiology. Lung cellular and molecular physiology.. 2005 Sep; 289(3):L391-9. Epub 2005 Apr 29.
2005 Apr 5
Palermo CM, Westlake CA, Gasiewicz TA. "Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein." Biochemistry.. 2005 Apr 5; 44(13):5041-52.
2005 Feb
Williamson MA, Gasiewicz TA, Opanashuk LA. "Aryl hydrocarbon receptor expression and activity in cerebellar granule neuroblasts: implications for development and dioxin neurotoxicity." Toxicological sciences : an official journal of the Society of Toxicology.. 2005 Feb; 83(2):340-8. Epub 2004 Nov 10.
2004 Jun
Filbrandt CR, Wu Z, Zlokovic B, Opanashuk L, Gasiewicz TA. "Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes." Neurotoxicology.. 2004 Jun; 25(4):605-16.
2004 May 14
Minsavage GD, Park SK, Gasiewicz TA. "The aryl hydrocarbon receptor (AhR) tyrosine 9, a residue that is essential for AhR DNA binding activity, is not a phosphoresidue but augments AhR phosphorylation." The Journal of biological chemistry.. 2004 May 14; 279(20):20582-93. Epub 2004 Feb 20.
2003 Nov 1
Laiosa MD, Wyman A, Murante FG, Fiore NC, Staples JE, Gasiewicz TA, Silverstone AE. "Cell proliferation arrest within intrathymic lymphocyte progenitor cells causes thymic atrophy mediated by the aryl hydrocarbon receptor." The Journal of immunology : official journal of the American Association of Immunologists.. 2003 Nov 1; 171(9):4582-91.
2003 Nov
Joiakim A, Mathieu PA, Palermo C, Gasiewicz TA, Reiners JJ. "The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor." Drug metabolism and disposition : the biological fate of chemicals.. 2003 Nov; 31(11):1279-82.
2003 Aug 1
Zhou J, Gasiewicz TA. "3'-methoxy-4'-nitroflavone, a reported aryl hydrocarbon receptor antagonist, enhances Cyp1a1 transcription by a dioxin responsive element-dependent mechanism." Archives of biochemistry and biophysics.. 2003 Aug 1; 416(1):68-80.
2003 Jul
Palermo CM, Hernando JI, Dertinger SD, Kende AS, Gasiewicz TA. "Identification of potential aryl hydrocarbon receptor antagonists in green tea." Chemical research in toxicology. 2003 Jul; 16(7):865-72.
2003 Apr 1
Minsavage GD, Vorojeikina DP, Gasiewicz TA. "Mutational analysis of the mouse aryl hydrocarbon receptor tyrosine residues necessary for recognition of dioxin response elements." Archives of biochemistry and biophysics.. 2003 Apr 1; 412(1):95-105.
2003 Apr
Zhou JG, Henry EC, Palermo CM, Dertinger SD, Gasiewicz TA. "Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements." Molecular pharmacology.. 2003 Apr; 63(4):915-24.
2003 Feb
Henry EC, Gasiewicz TA. "Agonist but not antagonist ligands induce conformational change in the mouse aryl hydrocarbon receptor as detected by partial proteolysis." Molecular pharmacology.. 2003 Feb; 63(2):392-400.
2002 Sep
Laiosa MD, Lai ZW, Thurmond TS, Fiore NC, DeRossi C, Holdener BC, Gasiewicz TA, Silverstone AE. "2,3,7,8-tetrachlorodibenzo-p-dioxin causes alterations in lymphocyte development and thymic atrophy in hemopoietic chimeras generated from mice deficient in ARNT2." Toxicological sciences : an official journal of the Society of Toxicology.. 2002 Sep; 69(1):117-24.
2002 May 1
Wyman A, Lavin AL, Wilding GE, Gasiewicz TA. "2,3,7,8-tetrachlorodibenzo-p-dioxin does not directly alter the phenotype of maturing B cells in a murine coculture system." Toxicology and applied pharmacology.. 2002 May 1; 180(3):164-77.
2001 Jun
Nazarenko DA, Dertinger SD, Gasiewicz TA. "In vivo antagonism of AhR-mediated gene induction by 3'-methoxy-4'-nitroflavone in TCDD-responsive lacZ mice." Toxicological sciences : an official journal of the Society of Toxicology.. 2001 Jun; 61(2):256-64.
2001 Apr
Nazarenko DA, Dertinger SD, Gasiewicz TA. "Enhanced detection of beta-galactosidase reporter activation is achieved by a reduction of hemoglobin content in tissue lysates." BioTechniques. 2001 Apr; 30(4):776-7, 780-1.
2001 Jan
Dertinger SD, Nazarenko DA, Silverstone AE, Gasiewicz TA. "Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo." Carcinogenesis.. 2001 Jan; 22(1):171-7.
2000 Nov
Thurmond TS, Gasiewicz TA. "A single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin produces a time- and dose-dependent alteration in the murine bone marrow B-lymphocyte maturation profile." Toxicological sciences : an official journal of the Society of Toxicology.. 2000 Nov; 58(1):88-95.
2000 Oct 1
Lai ZW, Fiore NC, Hahn PJ, Gasiewicz TA, Silverstone AE. "Differential effects of diethylstilbestrol and 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocyte differentiation, proliferation, and apoptosis in bcl-2 transgenic mouse fetal thymus organ culture." Toxicology and applied pharmacology.. 2000 Oct 1; 168(1):15-24.
2000 Sep 15
Park S, Henry EC, Gasiewicz TA. "Regulation of DNA binding activity of the ligand-activated aryl hydrocarbon receptor by tyrosine phosphorylation." Archives of biochemistry and biophysics.. 2000 Sep 15; 381(2):302-12.
2000 Jul 15
Dertinger SD, Lantum HB, Silverstone AE, Gasiewicz TA. "Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms." Biochemical pharmacology.. 2000 Jul 15; 60(2):189-96.
2000 Jul
Thurmond TS, Murante FG, Staples JE, Silverstone AE, Korach KS, Gasiewicz TA. "Role of estrogen receptor alpha in hematopoietic stem cell development and B lymphocyte maturation in the male mouse." Endocrinology.. 2000 Jul; 141(7):2309-18.
2000 Jun 15
Thurmond TS, Staples JE, Silverstone AE, Gasiewicz TA. "The aryl hydrocarbon receptor has a role in the in vivo maturation of murine bone marrow B lymphocytes and their response to 2,3,7,8-tetrachlorodibenzo-p-dioxin." Toxicology and applied pharmacology.. 2000 Jun 15; 165(3):227-36.
2000 Apr
Murante FG, Gasiewicz TA. "Hemopoietic progenitor cells are sensitive targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J mice." Toxicological sciences : an official journal of the Society of Toxicology.. 2000 Apr; 54(2):374-83.
2000 Jan 24
Dertinger SD, Torous DK, Hall NE, Tometsko CR, Gasiewicz TA. "Malaria-infected erythrocytes serve as biological standards to ensure reliable and consistent scoring of micronucleated erythrocytes by flow cytometry." Mutation research.. 2000 Jan 24; 464(2):195-200.
2000
Gasiewicz TA, Thurmond TS, Staples JE, Murante FG, Silverstone AE. "Use of bone marrow chimeras to identify cell targets in the immune system for the actions of chemicals." Annals of the New York Academy of Sciences.. 2000 919:300-3.
1999 Oct 26
Yudt MR, Vorojeikina D, Zhong L, Skafar DF, Sasson S, Gasiewicz TA, Notides AC. "Function of estrogen receptor tyrosine 537 in hormone binding, DNA binding, and transactivation." Biochemistry.. 1999 Oct 26; 38(43):14146-56.
1999 Oct 15
Staples JE, Gasiewicz TA, Fiore NC, Lubahn DB, Korach KS, Silverstone AE. "Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations." The Journal of immunology : official journal of the American Association of Immunologists.. 1999 Oct 15; 163(8):4168-74.
1999 Jul 1
Thurmond TS, Silverstone AE, Baggs RB, Quimby FW, Staples JE, Gasiewicz TA. "A chimeric aryl hydrocarbon receptor knockout mouse model indicates that aryl hydrocarbon receptor activation in hematopoietic cells contributes to the hepatic lesions induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin." Toxicology and applied pharmacology.. 1999 Jul 1; 158(1):33-40.
1999 Apr
Henry EC, Kende AS, Rucci G, Totleben MJ, Willey JJ, Dertinger SD, Pollenz RS, Jones JP, Gasiewicz TA. "Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation." Molecular pharmacology.. 1999 Apr; 55(4):716-25.
1998 Nov
Dertinger SD, Silverstone AE, Gasiewicz TA. "Influence of aromatic hydrocarbon receptor-mediated events on the genotoxicity of cigarette smoke condensate." Carcinogenesis.. 1998 Nov; 19(11):2037-42.
1998 Jul
Willey JJ, Stripp BR, Baggs RB, Gasiewicz TA. "Aryl hydrocarbon receptor activation in genital tubercle, palate, and other embryonic tissues in 2,3,7, 8-tetrachlorodibenzo-p-dioxin-responsive lacZ mice." Toxicology and applied pharmacology.. 1998 Jul; 151(1):33-44.
1998 Jul
Staples JE, Fiore NC, Frazier DE, Gasiewicz TA, Silverstone AE. "Overexpression of the anti-apoptotic oncogene, bcl-2, in the thymus does not prevent thymic atrophy induced by estradiol or 2,3,7, 8-tetrachlorodibenzo-p-dioxin." Toxicology and applied pharmacology.. 1998 Jul; 151(1):200-10.
1998 Apr 15
Staples JE, Murante FG, Fiore NC, Gasiewicz TA, Silverstone AE. "Thymic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells." The Journal of immunology : official journal of the American Association of Immunologists.. 1998 Apr 15; 160(8):3844-54.
1998 Apr 1
Lavin AL, Hahn DJ, Gasiewicz TA. "Expression of functional aromatic hydrocarbon receptor and aromatic hydrocarbon nuclear translocator proteins in murine bone marrow stromal cells." Archives of biochemistry and biophysics.. 1998 Apr 1; 352(1):9-18.
1998 Apr
Lai ZW, Fiore NC, Gasiewicz TA, Silverstone AE. "2,3,7,8-Tetrachlorodibenzo-p-dioxin and diethylstilbestrol affect thymocytes at different stages of development in fetal thymus organ culture." Toxicology and applied pharmacology.. 1998 Apr; 149(2):167-77.
1997 Mar 15
Henry EC, Kent TA, Gasiewicz TA. "DNA binding and transcriptional enhancement by purified TCDD.Ah receptor complex." Archives of biochemistry and biophysics.. 1997 Mar 15; 339(2):305-14.
1997
Gasiewicz TA. "Dioxins and the Ah receptor: probes to uncover processes in neuroendocrine development." Neurotoxicology.. 1997 18(2):393-413.
1996 Mar
Germolec DR, Henry EC, Maronpot R, Foley JF, Adams NH, Gasiewicz TA, Luster MI. "Induction of CYP1A1 and ALDH-3 in lymphoid tissues from Fisher 344 rats exposed to 2,3,7,8-tetrachlorodibenzodioxin (TCDD)." Toxicology and applied pharmacology.. 1996 Mar; 137(1):57-66.
1996
Gasiewicz TA, Kende AS, Rucci G, Whitney B, Willey JJ. "Analysis of structural requirements for Ah receptor antagonist activity: ellipticines, flavones, and related compounds." Biochemical pharmacology.. 1996 52(11):1787-803.
1995 Sep
DeVito MJ, Birnbaum LS, Farland WH, Gasiewicz TA. "Comparisons of estimated human body burdens of dioxinlike chemicals and TCDD body burdens in experimentally exposed animals." Environmental health perspectives.. 1995 Sep; 103(9):820-31.
1995 Aug
White TE, Rucci G, Liu Z, Gasiewicz TA. "Weanling female Sprague-Dawley rats are not sensitive to the antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)." Toxicology and applied pharmacology.. 1995 Aug; 133(2):313-20.
1995 Apr 1
Mahon MJ, Gasiewicz TA. "Ah receptor phosphorylation: localization of phosphorylation sites to the C-terminal half of the protein." Archives of biochemistry and biophysics.. 1995 Apr 1; 318(1):166-74.
1994 Jun 1
Frazier DE, Silverstone AE, Gasiewicz TA. "2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced thymic atrophy and lymphocyte stem cell alterations by mechanisms independent of the estrogen receptor." Biochemical pharmacology.. 1994 Jun 1; 47(11):2039-48.
1994 Jun
Silverstone AE, Frazier DE, Fiore NC, Soults JA, Gasiewicz TA. "Dexamethasone, beta-estradiol, and 2,3,7,8-tetrachlorodibenzo-p-dioxin elicit thymic atrophy through different cellular targets." Toxicology and applied pharmacology.. 1994 Jun; 126(2):248-59.
1994 Feb
Frazier DE, Silverstone AE, Soults JA, Gasiewicz TA. "The thymus does not mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin-elicited alterations in bone marrow lymphocyte stem cells." Toxicology and applied pharmacology.. 1994 Feb; 124(2):242-7.
1994
Henry EC, Rucci G, Gasiewicz TA. "Purification to homogeneity of the heteromeric DNA-binding form of the aryl hydrocarbon receptor from rat liver." Molecular pharmacology.. 1994 46(6):1022-7.
1994
Silverstone AE, Frazier DE, Gasiewicz TA. "Alternate immune system targets for TCDD: lymphocyte stem cells and extrathymic T-cell development." Experimental and clinical immunogenetics.. 1994 11(2-3):94-101.
1993 Aug 15
Henry EC, Gasiewicz TA. "Transformation of the aryl hydrocarbon receptor to a DNA-binding form is accompanied by release of the 90 kDa heat-shock protein and increased affinity for 2,3,7,8-tetrachlorodibenzo-p-dioxin." The Biochemical journal.. 1993 Aug 15; 294 ( Pt 1):95-101.
1993 Jun 30
White TE, Gasiewicz TA. "The human estrogen receptor structural gene contains a DNA sequence that binds activated mouse and human Ah receptors: a possible mechanism of estrogen receptor regulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin." Biochemical and biophysical research communications.. 1993 Jun 30; 193(3):956-62.
1992 Aug 15
Mahon MJ, Gasiewicz TA. "Chelatable metal ions are not required for aryl hydrocarbon receptor transformation to a DNA binding form: phenanthrolines are possible competitive antagonists of 2,3,7,8-tetrachlorodibenzo-p-dioxin." Archives of biochemistry and biophysics.. 1992 Aug 15; 297(1):1-8.
1991 Nov 1
Henry EC, Hayden KA, Bauman PA, Gasiewicz TA. "Ribonuclease inhibits Ah receptor transformation in vitro." The Biochemical journal.. 1991 Nov 1; 279 ( Pt 3):689-94.
1991 Nov
Gasiewicz TA, Rucci G. "Alpha-naphthoflavone acts as an antagonist of 2,3,7, 8-tetrachlorodibenzo-p-dioxin by forming an inactive complex with the Ah receptor." Molecular pharmacology.. 1991 Nov; 40(5):607-12.
1991 Jul
Henry EC, Gasiewicz TA. "Inhibition and reconstitution of Ah receptor transformation in vitro: role and partial characterization of a cytosolic factor(s)." Archives of biochemistry and biophysics.. 1991 Jul; 288(1):149-56.
1991 Mar 19
Gasiewicz TA, Elferink CJ, Henry EC. "Characterization of multiple forms of the Ah receptor: recognition of a dioxin-responsive enhancer involves heteromer formation." Biochemistry.. 1991 Mar 19; 30(11):2909-16.
1991 Feb 15
Hahn ME, Gasiewicz TA. "Determination of individual porphyrins in rodent urine using high-performance liquid chromatography following clean-up by anion-exchange chromatography." Journal of chromatography.. 1991 Feb 15; 563(2):363-8.
1990 Nov 25
Elferink CJ, Gasiewicz TA, Whitlock JP. "Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric." The Journal of biological chemistry.. 1990 Nov 25; 265(33):20708-12.
1990 Nov
Ryan JJ, Gasiewicz TA, Brown JF. "Human body burden of polychlorinated dibenzofurans associated with toxicity based on the yusho and yucheng incidents." Fundamental and applied toxicology : official journal of the Society of Toxicology.. 1990 Nov; 15(4):722-31.
1990 Oct
Fine JS, Gasiewicz TA, Fiore NC, Silverstone AE. "Prothymocyte activity is reduced by perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure." The Journal of pharmacology and experimental therapeutics.. 1990 Oct; 255(1):128-32.
1990 Feb 15
Fine JS, Silverstone AE, Gasiewicz TA. "Impairment of prothymocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin." The Journal of immunology : official journal of the American Association of Immunologists.. 1990 Feb 15; 144(4):1169-76.
1989 Jul 25
Henry EC, Rucci G, Gasiewicz TA. "Characterization of multiple forms of the Ah receptor: comparison of species and tissues." Biochemistry.. 1989 Jul 25; 28(15):6430-40.
1989 Apr
Hahn ME, Goldstein JA, Linko P, Gasiewicz TA. "Interaction of hexachlorobenzene with the receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro and in vivo. Evidence that hexachlorobenzene is a weak Ah receptor agonist." Archives of biochemistry and biophysics.. 1989 Apr; 270(1):344-55.
1989 Jan
Fine JS, Gasiewicz TA, Silverstone AE. "Lymphocyte stem cell alterations following perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin." Molecular pharmacology.. 1989 Jan; 35(1):18-25.
1989
Ackermann MF, Gasiewicz TA, Lamm KR, Germolec DR, Luster MI. "Selective inhibition of polymorphonuclear neutrophil activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin." Toxicology and applied pharmacology.. 1989 101(3):470-80.
1989
Silbergeld EK, Gasiewicz TA. "Dioxins and the Ah receptor." American journal of industrial medicine.. 1989 16(4):455-74.
1988 Aug 15
Rucci G, Gasiewicz TA. "In vivo kinetics and DNA-binding properties of the Ah receptor in the golden Syrian hamster." Archives of biochemistry and biophysics.. 1988 Aug 15; 265(1):197-207.
1988 Aug 15
Hahn ME, Gasiewicz TA, Linko P, Goldstein JA. "The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice." The Biochemical journal.. 1988 Aug 15; 254(1):245-54.
1988 Mar 17
Henry EC, Kester JE, Gasiewicz TA. "Effects of SH-modifying reagents on the rat hepatic Ah receptor: inhibition of ligand binding and transformation, and disruption of the ligand-receptor complex." Biochimica et biophysica acta.. 1988 Mar 17; 964(3):361-76.
1987 Aug 13
Kester JE, Gasiewicz TA. "Influence of proteinase inhibitors and substrates on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-binding capacity of the rat hepatic Ah receptor." Biochimica et biophysica acta.. 1987 Aug 13; 925(2):109-16.
1987 Jul
Blank JA, Tucker AN, Sweatlock J, Gasiewicz TA, Luster MI. "alpha-Naphthoflavone antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced murine lymphocyte ethoxyresorufin-O-deethylase activity and immunosuppression." Molecular pharmacology.. 1987 Jul; 32(1):169-72.
1987 Jun 30
Henry EC, Gasiewicz TA. "Changes in thyroid hormones and thyroxine glucuronidation in hamsters compared with rats following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin." Toxicology and applied pharmacology.. 1987 Jun 30; 89(2):165-74.
1987 Feb 15
Gasiewicz TA, Bauman PA. "Heterogeneity of the rat hepatic Ah receptor and evidence for transformation in vitro and in vivo." The Journal of biological chemistry.. 1987 Feb 15; 262(5):2116-20.
1987 Feb 1
Kester JE, Gasiewicz TA. "Characterization of the in vitro stability of the rat hepatic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)." Archives of biochemistry and biophysics.. 1987 Feb 1; 252(2):606-25.
1986 Aug 15
Gasiewicz TA, Rucci G, Henry EC, Baggs RB. "Changes in hamster hepatic cytochrome P-450, ethoxycoumarin O-deethylase, and reduced NAD(P): menadione oxidoreductase following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Partial dissociation of temporal and dose-response relationships from elicited toxicity." Biochemical pharmacology.. 1986 Aug 15; 35(16):2737-42.
1986 Aug
Lu CJ, Redmond D, Baggs RB, Schecter A, Gasiewicz TA. "Growth and hepatic composition in the guinea pig after long-term parenteral hyperalimentation." The American journal of physiology.. 1986 Aug; 251(2 Pt 2):R388-97.
1986 Jul
Huang Lu CJ, Baggs RB, Redmond D, Henry EC, Schecter A, Gasiewicz TA. "Toxicity and evidence for metabolic alterations in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated guinea pigs fed by total parenteral nutrition." Toxicology and applied pharmacology.. 1986 Jul; 84(3):439-53.
1986 Jun
Linko P, Yeowell HN, Gasiewicz TA, Goldstein JA. "Induction of cytochrome P-450 isozymes by hexachlorobenzene in rats and aromatic hydrocarbon (Ah)-responsive mice." Journal of biochemical toxicology.. 1986 Jun; 1(2):95-107.
1986
Henry EC, Gasiewicz TA. "Effects of thyroidectomy on the Ah receptor and enzyme inducibility by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat liver." Chemico-biological interactions.. 1986 59(1):29-42.
1986
Goldstein JA, Linko P, Hahn ME, Gasiewicz TA, Yeowell HN. "Structure-activity relationships of chlorinated benzenes as inducers of hepatic cytochrome P-450 isozymes in the rat." IARC scientific publications.. 1986 (77):519-26.
1984 Jul
Gasiewicz TA, Rucci G. "Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species." Molecular pharmacology.. 1984 Jul; 26(1):90-8.
1984 Mar 22
Gasiewicz TA, Rucci G. "Examination and rapid analysis of hepatic cytosolic receptors for 2,3,7,8-tetrachlorodibenzo-p-dioxin using gel-permeation high performance liquid chromatography." Biochimica et biophysica acta.. 1984 Mar 22; 798(1):37-45.
1984 Jan 13
Gasiewicz TA, Ness WC, Rucci G. "Ontogeny of the cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver, lung, and thymus." Biochemical and biophysical research communications.. 1984 Jan 13; 118(1):183-90.
1983
Gasiewicz TA, Geiger LE, Rucci G, Neal RA. "Distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J, DBA/2J, and B6D2F1/J mice." Drug metabolism and disposition : the biological fate of chemicals.. 1983 11(5):397-403.
1982 Jul 15
Gasiewicz TA, Neal RA. "The examination and quantitation of tissue cytosolic receptors for 2,3,7,8-tetrachlorodibenzo-p-dioxin using hydroxylapatite." Analytical biochemistry.. 1982 Jul 15; 124(1):1-11.
1982
Neal RA, Olson JR, Gasiewicz TA, Geiger LE. "The toxicokinetics of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in mammalian systems." Drug metabolism reviews.. 1982 13(3):355-85.
1981 Jul
Swift LL, Gasiewicz TA, Dunn GD, Soulé PD, Neal RA. "Characterization of the hyperlipidemia in guinea pigs induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin." Toxicology and applied pharmacology.. 1981 Jul; 59(3):489-99.
1980 Oct
Olson JR, Gasiewicz TA, Neal RA. "Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the Golden Syrian hamster." Toxicology and applied pharmacology.. 1980 Oct; 56(1):78-85.
1980 Jul
Gasiewicz TA, Holscher MA, Neal RA. "The effect of total parenteral nutrition on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat." Toxicology and applied pharmacology.. 1980 Jul; 54(3):469-88.
1979 Nov
Gasiewicz TA, Neal RA. "2,3,7,8-Tetrachlorodibenzo-p-dioxin tissue distribution, excretion, and effects on clinical chemical parameters in guinea pigs." Toxicology and applied pharmacology.. 1979 Nov; 51(2):329-39.
1979 May 31
Neal RA, Beatty PW, Gasiewicz TA. "Studies of the mechanisms of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)." Annals of the New York Academy of Sciences.. 1979 May 31; 320:204-13.
1978 Nov
Gasiewicz TA, Smith JC. "Properties of the cadmium and selenium complex formed in rat plasma in vivo and in vitro." Chemico-biological interactions.. 1978 Nov; 23(2):171-83.
1978 Aug
Gasiewicz TA, Smith JC. "Interaction between cadmium and selenium in rat plasma." Environmental health perspectives.. 1978 Aug; 25:133-6.
1978 Jun
Gasiewicz TA, Smith JC. "The metabolism of selenite by intact rat erythrocytes in vitro." Chemico-biological interactions.. 1978 Jun; 21(2-3):299-313.
1976 Mar 25
Gasiewicz TA, Smith JC. "Interactions of cadmium and selenium in rat plasma in vivo and in vitro." Biochimica et biophysica acta.. 1976 Mar 25; 428(1):113-121.

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