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Thomas Thatcher, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 692
Rochester, NY 14642

Office: (585) 273-5170
Lab: (585) 275-3275
Fax: (585) 273-1114

Books

2007
Sime PJ, Kottmann RM, Lakatos HF and Thatcher TH. "The Role of TGF-beta in Radiation and Chemotherapy-Induced Pulmonary Fibrosis: Inhibition of TGF-beta as a Novel Therapeutic Strategy.". Cancer Drug Discovery and Development: TGF-beta in Cancer Therapy. Jakowlew SB. Totowa, NJ: Humana Press Inc., 2007. 627-645
2005
Phipps R, Beckett WS, Kaufman J, Martey C, Sime PJ, Thatcher, TH. "Anti-inflammatory therapies for lung injury". Lung Injury: Mechanisms, Pathophysiology and Therapy. Notter, R., Finkelstein, J. and Holm, B.. : Marcel Dekker, 2005.

Journal Articles

Showing all 26 journal articles available.

2012
Kulkarni AA, Woeller CF, Thatcher TH, Ramon S, Phipps RP, Sime PJ. "Emerging PPAR?-Independent Role of PPAR? Ligands in Lung Diseases." PPAR research. 2012 2012:705352. Epub 2012 Jun 18.
2011
Kulkarni AA, Thatcher TH, Olsen KC, Maggirwar SB, Phipps RP, Sime PJ. "PPAR-? ligands repress TGF?-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis." PloS one. 2011 6(1):e15909. Epub 2011 Jan 06.
2011
Hogan CM, Thatcher TH, Sapinoro RE, Gurell MN, Ferguson HE, Pollock SJ, Jones C, Phipps RP, Sime PJ. "Electrophilic PPAR? Ligands Attenuate IL-1? and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPAR?-Independent Mechanism." PPAR research. 2011 2011:318134. Epub 2011 Jun 16.
2009 Nov
Ferguson HE, Thatcher TH, Olsen KC, Garcia-Bates TM, Baglole CJ, Kottmann RM, Strong ER, Phipps RP, Sime PJ. "Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism." American journal of physiology. Lung cellular and molecular physiology.. 2009 Nov; 297(5):L912-9. Epub 2009 Sep 04.
2009
Ferguson HE, Kulkarni A, Lehmann GM, Garcia-Bates TM, Thatcher TH, Huxlin KR, Phipps RP, Sime PJ. "Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts." American journal of respiratory cell and molecular biology.. 2009 41(6):722-30. Epub 2009 Mar 13.
2008 Oct 24
Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ. "The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB." The Journal of biological chemistry.. 2008 Oct 24; 283(43):28944-57. Epub 2008 Aug 12.
2008 Sep
Thatcher TH, Benson RP, Phipps RP, Sime PJ. "High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function." American journal of physiology. Lung cellular and molecular physiology.. 2008 Sep; 295(3):L412-21. Epub 2008 Jun 20.
2007 Mar
Thatcher TH, Maggirwar SB, Baglole CJ, Lakatos HF, Gasiewicz TA, Phipps RP, Sime PJ. "Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB." The American journal of pathology.. 2007 Mar; 170(3):855-64.
2007
Lakatos HF, Thatcher TH, Kottmann RM, Garcia TM, Phipps RP, Sime PJ. "The Role of PPARs in Lung Fibrosis." PPAR research. 2007 2007:71323.
2006 May
Lakatos HF, Burgess HA, Thatcher TH, Redonnet MR, Hernady E, Williams JP, Sime PJ. "Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation." Experimental lung research. 2006 May; 32(5):181-99.
2006 Apr
Thatcher TH, Luzina I, Fishelevich R, Tomai MA, Miller RL, Gaspari AA. "Topical imiquimod treatment prevents UV-light induced loss of contact hypersensitivity and immune tolerance." The Journal of investigative dermatology.. 2006 Apr; 126(4):821-31.
2005 Nov
Feldon SE, Park DJ, O'Loughlin CW, Nguyen VT, Landskroner-Eiger S, Chang D, Thatcher TH, Phipps RP. "Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy." Investigative ophthalmology & visual science.. 2005 Nov; 46(11):3913-21.
2005 Sep
Thatcher TH, Sime PJ, Barth RK. "Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire." Experimental lung research. 2005 Sep; 31(7):685-700.
2005 Aug
Thatcher TH, McHugh NA, Egan RW, Chapman RW, Hey JA, Turner CK, Redonnet MR, Seweryniak KE, Sime PJ, Phipps RP. "Role of CXCR2 in cigarette smoke-induced lung inflammation." American journal of physiology. Lung cellular and molecular physiology.. 2005 Aug; 289(2):L322-8. Epub 2005 Apr 15.
2005 Jun
O'Reilly KM, Phipps RP, Thatcher TH, Graf BA, Van Kirk J, Sime PJ. "Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis." American journal of physiology. Lung cellular and molecular physiology.. 2005 Jun; 288(6):L1010-6. Epub 2005 Jan 21.
2005 Jun
Burgess HA, Daugherty LE, Thatcher TH, Lakatos HF, Ray DM, Redonnet M, Phipps RP, Sime PJ. "PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis." American journal of physiology. Lung cellular and molecular physiology.. 2005 Jun; 288(6):L1146-53. Epub 2005 Feb 25.
2002 Oct
Gaspari AA, Thatcher T, Burns RP, Ferbel B, Tanck C, Bedi GS, Perrella FW. "Bacterial protease treatment of natural rubber latex alters its primary immunogenicity in a mouse model of sensitization." Clinical immunology : the official journal of the Clinical Immunology Society.. 2002 Oct; 105(1):9-16.
2000 Feb
Thatcher TH, O'Brien DP, Altuwaijri S, Barth RK. "Increasing the frequency of T-cell precursors specific for a cryptic epitope of hen-egg lysozyme converts it to an immunodominant epitope." Immunology. 2000 Feb; 99(2):235-42.
1994 May 10
Gaertig J, Thatcher TH, Gu L, Gorovsky MA. "Electroporation-mediated replacement of a positively and negatively selectable beta-tubulin gene in Tetrahymena thermophila." Proceedings of the National Academy of Sciences of the United States of America.. 1994 May 10; 91(10):4549-53.
1994 Jan 25
Thatcher TH, Gorovsky MA. "Phylogenetic analysis of the core histones H2A, H2B, H3, and H4." Nucleic acids research.. 1994 Jan 25; 22(2):174-9.
1994 Jan 25
Thatcher TH, MacGaffey J, Bowen J, Horowitz S, Shapiro DL, Gorovsky MA. "Independent evolutionary origin of histone H3.3-like variants of animals and Tetrahymena." Nucleic acids research.. 1994 Jan 25; 22(2):180-6.
1994 Jan
Wu M, Allis CD, Sweet MT, Cook RG, Thatcher TH, Gorovsky MA. "Four distinct and unusual linker proteins in a mitotically dividing nucleus are derived from a 71-kilodalton polyprotein, lack p34cdc2 sites, and contain protein kinase A sites." Molecular and cellular biology. 1994 Jan; 14(1):10-20.
1993
Gaertig J, Thatcher TH, McGrath KE, Callahan RC, Gorovsky MA. "Perspectives on tubulin isotype function and evolution based on the observation that Tetrahymena thermophila microtubules contain a single alpha- and beta-tubulin." Cell motility and the cytoskeleton. 1993 25(3):243-53.
1993
Thatcher TH, Gorovsky MA. "A temperature-sensitive cell cycle arrest mutation affecting H1 phosphorylation and nuclear localization of a small heat shock protein in Tetrahymena thermophila." Experimental cell research.. 1993 209(2):261-70.
1988 Nov
Pennock DG, Thatcher T, Bowen J, Bruns PJ, Gorovsky MA. "A conditional mutant having paralyzed cilia and a block in cytokinesis is rescued by cytoplasmic exchange in Tetrahymena thermophila." Genetics. 1988 Nov; 120(3):697-705.
1988 Jul
Pennock DG, Thatcher T, Gorovsky MA. "A temperature-sensitive mutation affecting cilia regeneration, nuclear development, and the cell cycle of Tetrahymena thermophila is rescued by cytoplasmic exchange." Molecular and cellular biology. 1988 Jul; 8(7):2681-9.