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Thomas Thatcher, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 692
Rochester, NY 14642

Office: (585) 273-5170
Lab: (585) 275-3275
Fax: (585) 273-1114

Journal Articles

Showing all 40 journal articles available.

2015 Aug 21
Croasdell A, Thatcher TH, Kottmann RM, Colas RA, Dalli J, Serhan CN, Sime PJ, Phipps RP. "Resolvins Attenuate Inflammation and Promote Resolution in Cigarette Smoke-Exposed Human Macrophages." American journal of physiology. Lung cellular and molecular physiology. 2015 Aug 21; :ajplung.00125.2015. Epub 2015 Aug 21.
2015 Aug 7
Judge JL, Owens KM, Pollock SJ, Woeller CF, Thatcher TH, Williams JP, Phipps RP, Sime PJ, Kottmann RM. "Ionizing Radiation Induces Myofibroblast Differentiation via Lactate Dehydrogenase." American journal of physiology. Lung cellular and molecular physiology. 2015 Aug 7; :ajplung.00153.2015. Epub 2015 Aug 07.
2015 Mar
Woeller CF, O'loughlin CW, Pollock SJ, Thatcher TH, Feldon SE, Phipps RP. "Thy1 (CD90) controls adipogenesis by regulating activity of the Src family kinase, Fyn." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015 Mar; 29(3):920-31. Epub 2014 Nov 21.
Epa AP, Thatcher TH, Pollock SJ, Wahl LA, Lyda E, Kottmann RM, Phipps RP, Sime PJ. "Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-? Induced Myofibroblast Differentiation via Prostaglandin E2." PloS one. 2015 10(8):e0135266. Epub 2015 Aug 06.
2014 Nov 15
Hsiao HM, Thatcher TH, Levy EP, Fulton RA, Owens KM, Phipps RP, Sime PJ. "Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1." The Journal of immunology : official journal of the American Association of Immunologists. 2014 Nov 15; 193(10):4980-7. Epub 2014 Oct 15.
2014 Jun 1
Lugade AA, Bogner PN, Thatcher TH, Sime PJ, Phipps RP, Thanavala Y. "Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection." The Journal of immunology : official journal of the American Association of Immunologists. 2014 Jun 1; 192(11):5226-35. Epub 2014 Apr 21.
2014 Apr
Olsen KC, Epa AP, Kulkarni AA, Kottmann RM, McCarthy CE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ. "Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules." American journal of respiratory cell and molecular biology. 2014 Apr; 50(4):737-47.
2013 Jul 15
Thatcher TH, Hsiao HM, Pinner E, Laudon M, Pollock SJ, Sime PJ, Phipps RP. "Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation." American journal of physiology. Lung cellular and molecular physiology. 2013 Jul 15; 305(2):L165-74. Epub 2013 May 17.
2013 Jun 1
McMillan DH, Woeller CF, Thatcher TH, Spinelli SL, Maggirwar SB, Sime PJ, Phipps RP. "Attenuation of inflammatory mediator production by the NF-?B member RelB is mediated by microRNA-146a in lung fibroblasts." American journal of physiology. Lung cellular and molecular physiology. 2013 Jun 1; 304(11):L774-81. Epub 2013 Apr 05.
Hsiao HM, Sapinoro RE, Thatcher TH, Croasdell A, Levy EP, Fulton RA, Olsen KC, Pollock SJ, Serhan CN, Phipps RP, Sime PJ. "A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation." PloS one. 2013 8(3):e58258. Epub 2013 Mar 06.
Kulkarni AA, Thatcher TH, Hsiao HM, Olsen KC, Kottmann RM, Morrissette J, Wright TW, Phipps RP, Sime PJ. "The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis." PloS one. 2013 8(5):e63798. Epub 2013 May 31.
2012 Nov 15
Ramon S, Bancos S, Thatcher TH, Murant TI, Moshkani S, Sahler JM, Bottaro A, Sime PJ, Phipps RP. "Peroxisome proliferator-activated receptor ? B cell-specific-deficient mice have an impaired antibody response." The Journal of immunology : official journal of the American Association of Immunologists. 2012 Nov 15; 189(10):4740-7. Epub 2012 Oct 05.
Kulkarni AA, Woeller CF, Thatcher TH, Ramon S, Phipps RP, Sime PJ. "Emerging PPAR?-Independent Role of PPAR? Ligands in Lung Diseases." PPAR research. 2012 2012:705352. Epub 2012 Jun 18.
2011 Sep 15
Olsen KC, Sapinoro RE, Kottman RM, Kulkarni AA, Iismaa SE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ. "Transglutaminase 2 and its role in pulmonary fibrosis." American journal of respiratory and critical care medicine. 2011 Sep 15; 184(6):699-707. Epub 2011 Jun 23.
2011 Jul
McMillan DH, Baglole CJ, Thatcher TH, Maggirwar S, Sime PJ, Phipps RP. "Lung-targeted overexpression of the NF-?B member RelB inhibits cigarette smoke-induced inflammation." The American journal of pathology. 2011 Jul; 179(1):125-33. Epub 2011 May 05.
Kulkarni AA, Thatcher TH, Olsen KC, Maggirwar SB, Phipps RP, Sime PJ. "PPAR-? ligands repress TGF?-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis." PloS one. 2011 6(1):e15909. Epub 2011 Jan 06.
Hogan CM, Thatcher TH, Sapinoro RE, Gurell MN, Ferguson HE, Pollock SJ, Jones C, Phipps RP, Sime PJ. "Electrophilic PPAR? Ligands Attenuate IL-1? and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPAR?-Independent Mechanism." PPAR research. 2011 2011:318134. Epub 2011 Jun 16.
2009 Nov
Ferguson HE, Thatcher TH, Olsen KC, Garcia-Bates TM, Baglole CJ, Kottmann RM, Strong ER, Phipps RP, Sime PJ. "Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism." American journal of physiology. Lung cellular and molecular physiology. 2009 Nov; 297(5):L912-9. Epub 2009 Sep 04.
Ferguson HE, Kulkarni A, Lehmann GM, Garcia-Bates TM, Thatcher TH, Huxlin KR, Phipps RP, Sime PJ. "Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts." American journal of respiratory cell and molecular biology. 2009 41(6):722-30. Epub 2009 Mar 13.
2008 Oct 24
Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ. "The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB." The Journal of biological chemistry. 2008 Oct 24; 283(43):28944-57. Epub 2008 Aug 12.
2008 Sep
Thatcher TH, Benson RP, Phipps RP, Sime PJ. "High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function." American journal of physiology. Lung cellular and molecular physiology. 2008 Sep; 295(3):L412-21. Epub 2008 Jun 20.
2007 Mar
Thatcher TH, Maggirwar SB, Baglole CJ, Lakatos HF, Gasiewicz TA, Phipps RP, Sime PJ. "Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB." The American journal of pathology. 2007 Mar; 170(3):855-64.
Lakatos HF, Thatcher TH, Kottmann RM, Garcia TM, Phipps RP, Sime PJ. "The Role of PPARs in Lung Fibrosis." PPAR research. 2007 2007:71323.
2006 May
Lakatos HF, Burgess HA, Thatcher TH, Redonnet MR, Hernady E, Williams JP, Sime PJ. "Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation." Experimental lung research. 2006 May; 32(5):181-99.
2006 Apr
Thatcher TH, Luzina I, Fishelevich R, Tomai MA, Miller RL, Gaspari AA. "Topical imiquimod treatment prevents UV-light induced loss of contact hypersensitivity and immune tolerance." The Journal of investigative dermatology. 2006 Apr; 126(4):821-31.
2005 Nov
Feldon SE, Park DJ, O'Loughlin CW, Nguyen VT, Landskroner-Eiger S, Chang D, Thatcher TH, Phipps RP. "Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy." Investigative ophthalmology & visual science. 2005 Nov; 46(11):3913-21.
2005 Sep
Thatcher TH, Sime PJ, Barth RK. "Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire." Experimental lung research. 2005 Sep; 31(7):685-700.
2005 Aug
Thatcher TH, McHugh NA, Egan RW, Chapman RW, Hey JA, Turner CK, Redonnet MR, Seweryniak KE, Sime PJ, Phipps RP. "Role of CXCR2 in cigarette smoke-induced lung inflammation." American journal of physiology. Lung cellular and molecular physiology. 2005 Aug; 289(2):L322-8. Epub 2005 Apr 15.
2005 Jun
O'Reilly KM, Phipps RP, Thatcher TH, Graf BA, Van Kirk J, Sime PJ. "Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis." American journal of physiology. Lung cellular and molecular physiology. 2005 Jun; 288(6):L1010-6. Epub 2005 Jan 21.
2005 Jun
Burgess HA, Daugherty LE, Thatcher TH, Lakatos HF, Ray DM, Redonnet M, Phipps RP, Sime PJ. "PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis." American journal of physiology. Lung cellular and molecular physiology. 2005 Jun; 288(6):L1146-53. Epub 2005 Feb 25.
2002 Oct
Gaspari AA, Thatcher T, Burns RP, Ferbel B, Tanck C, Bedi GS, Perrella FW. "Bacterial protease treatment of natural rubber latex alters its primary immunogenicity in a mouse model of sensitization." Clinical immunology : the official journal of the Clinical Immunology Society. 2002 Oct; 105(1):9-16.
2000 Feb
Thatcher TH, O'Brien DP, Altuwaijri S, Barth RK. "Increasing the frequency of T-cell precursors specific for a cryptic epitope of hen-egg lysozyme converts it to an immunodominant epitope." Immunology. 2000 Feb; 99(2):235-42.
1994 May 10
Gaertig J, Thatcher TH, Gu L, Gorovsky MA. "Electroporation-mediated replacement of a positively and negatively selectable beta-tubulin gene in Tetrahymena thermophila." Proceedings of the National Academy of Sciences of the United States of America. 1994 May 10; 91(10):4549-53.
1994 Jan 25
Thatcher TH, Gorovsky MA. "Phylogenetic analysis of the core histones H2A, H2B, H3, and H4." Nucleic acids research. 1994 Jan 25; 22(2):174-9.
1994 Jan 25
Thatcher TH, MacGaffey J, Bowen J, Horowitz S, Shapiro DL, Gorovsky MA. "Independent evolutionary origin of histone H3.3-like variants of animals and Tetrahymena." Nucleic acids research. 1994 Jan 25; 22(2):180-6.
1994 Jan
Wu M, Allis CD, Sweet MT, Cook RG, Thatcher TH, Gorovsky MA. "Four distinct and unusual linker proteins in a mitotically dividing nucleus are derived from a 71-kilodalton polyprotein, lack p34cdc2 sites, and contain protein kinase A sites." Molecular and cellular biology. 1994 Jan; 14(1):10-20.
Gaertig J, Thatcher TH, McGrath KE, Callahan RC, Gorovsky MA. "Perspectives on tubulin isotype function and evolution based on the observation that Tetrahymena thermophila microtubules contain a single alpha- and beta-tubulin." Cell motility and the cytoskeleton. 1993 25(3):243-53.
Thatcher TH, Gorovsky MA. "A temperature-sensitive cell cycle arrest mutation affecting H1 phosphorylation and nuclear localization of a small heat shock protein in Tetrahymena thermophila." Experimental cell research. 1993 209(2):261-70.
1988 Nov
Pennock DG, Thatcher T, Bowen J, Bruns PJ, Gorovsky MA. "A conditional mutant having paralyzed cilia and a block in cytokinesis is rescued by cytoplasmic exchange in Tetrahymena thermophila." Genetics. 1988 Nov; 120(3):697-705.
1988 Jul
Pennock DG, Thatcher T, Gorovsky MA. "A temperature-sensitive mutation affecting cilia regeneration, nuclear development, and the cell cycle of Tetrahymena thermophila is rescued by cytoplasmic exchange." Molecular and cellular biology. 1988 Jul; 8(7):2681-9.


Sime PJ, Kottmann RM, Lakatos HF and Thatcher TH. "The Role of TGF-beta in Radiation and Chemotherapy-Induced Pulmonary Fibrosis: Inhibition of TGF-beta as a Novel Therapeutic Strategy.". Cancer Drug Discovery and Development: TGF-beta in Cancer Therapy. Jakowlew SB. Totowa, NJ: Humana Press Inc., 2007. 627-645
Phipps R, Beckett WS, Kaufman J, Martey C, Sime PJ, Thatcher, TH. "Anti-inflammatory therapies for lung injury". Lung Injury: Mechanisms, Pathophysiology and Therapy. Notter, R., Finkelstein, J. and Holm, B.. : Marcel Dekker, 2005.