After a period as Assistant Professor of Statistics at Harvard University I returned to London in 1977 as Senior Lecturer in Occupational Health Statistics at the London School of Hygiene and Tropical Medicine, where I became involved in the design and analysis of idemiologic studies of cancer and respiratory diseases, and in the education of occupational health professionals.
Since coming to Rochester in 1983 I have become deeply involved in clinical trials. I direct the Biostatistics Centers of the Parkinson and Huntington Study Groups, two consortia of scientific investigators and researchers, committed to advancing knowledge about these diseases through the planning, implementation and reporting of clinical trials of promising therapeutic interventions.
I have also worked in cardiology, infectious diseases and pediatrics, and am the Director of the Biostatistics Core facility for the Environmental Health Science Center at the University of Rochester. I am currently involved in several multicenter clinical trials and other initiatives in Parkinson's disease and Huntington's disease, and in a study of the influence of genetic polymorphisms on the risk of recurrent cardiac events after acute myocardial infarction.
At Rochester, I have taught courses in undergraduate probability and statistics and a variety of graduate level courses, including probability, stochastic processes, statistical inference, statistical modeling techniques and survival analysis. I have been involved in the education of medical students and fellows. I hold a training grant in environmental health sciences biostatistics and am co-director of a training grant in experimental therapeutics in neurology. I have Chaired the Departments of Statistics (1989-95) and of Biostatistics (1995-2002).
I have advised a total of eight graduate students, One (Ben Armstrong) is now a Reader in Epidemiological Statistics at London University, another (Amita Manatunga) is Associate Professor at Emory. Four others hold academic positions.
I am a Fellow of the American Statistical Association and an elected member of the International Statistical Institute. I serve on the NIH Study Section "Biostatistical Methods and Research Design" which reviews many grant applications in biostatistical methodology. I am the longest serving associate editor of the leading journal Biometrika (since 1979), and am one of three Editors of the journal Lifetime Data Analysis. I have authored or co-authored over 120 publications. About half of these are methodologic papers in the statistical and biostatistical literature and half are collaborative works, in recent years mostly in Neurology journals. A selection of the methodologic papers is given below. For a full c.v., which includes a complete list of all my publications, click here.