David Oakes, Ph.D.

David Oakes, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 630
Rochester, NY 14642

Research Bio

After a period as Assistant Professor of Statistics at Harvard University I returned to London in 1977 as Senior Lecturer in Occupational Health Statistics at the London School of Hygiene and Tropical Medicine, where I became involved in the design and analysis of idemiologic studies of cancer and respiratory diseases, and in the education of occupational health professionals.

Since coming to Rochester in 1983 I have become deeply involved in clinical trials. I direct the Biostatistics Centers of the Parkinson and Huntington Study Groups, two consortia of scientific investigators and researchers, committed to advancing knowledge about these diseases through the planning, implementation and reporting of clinical trials of promising therapeutic interventions.

I have also worked in cardiology, infectious diseases and pediatrics, and am the Director of the Biostatistics Core facility for the Environmental Health Science Center at the University of Rochester. I am currently involved in several multicenter clinical trials and other initiatives in Parkinson's disease and Huntington's disease, and in a study of the influence of genetic polymorphisms on the risk of recurrent cardiac events after acute myocardial infarction.

At Rochester, I have taught courses in undergraduate probability and statistics and a variety of graduate level courses, including probability, stochastic processes, statistical inference, statistical modeling techniques and survival analysis. I have been involved in the education of medical students and fellows. I hold a training grant in environmental health sciences biostatistics and am co-director of a training grant in experimental therapeutics in neurology. I have Chaired the Departments of Statistics (1989-95) and of Biostatistics (1995-2002).

I have advised a total of eight graduate students, One (Ben Armstrong) is now a Reader in Epidemiological Statistics at London University, another (Amita Manatunga) is Associate Professor at Emory. Four others hold academic positions.

I am a Fellow of the American Statistical Association and an elected member of the International Statistical Institute. I serve on the NIH Study Section "Biostatistical Methods and Research Design" which reviews many grant applications in biostatistical methodology. I am the longest serving associate editor of the leading journal Biometrika (since 1979), and am one of three Editors of the journal Lifetime Data Analysis. I have authored or co-authored over 120 publications. About half of these are methodologic papers in the statistical and biostatistical literature and half are collaborative works, in recent years mostly in Neurology journals. A selection of the methodologic papers is given below. For a full c.v., which includes a complete list of all my publications, click here.

Recent Journal Articles

Showing the 5 most recent journal articles. 130 available »

2014 May 20
Marek K, Seibyl J, Eberly S, Oakes D, Shoulson I, Lang AE, Hyson C, Jennings D, . "Longitudinal follow-up of SWEDD subjects in the PRECEPT Study." Neurology.. 2014 May 20; 82(20):1791-7. Epub 2014 Apr 23.
2014 May
, Beal MF, Oakes D, Shoulson I, Henchcliffe C, Galpern WR, Haas R, Juncos JL, Nutt JG, Voss TS, Ravina B, Shults CM, Helles K, Snively V, Lew MF, Griebner B, Watts A, Gao S, Pourcher E, Bond L, Kompoliti K, Agarwal P, Sia C, Jog M, Cole L, Sultana M, Kurlan R, Richard I, Deeley C, Waters CH, Figueroa A, Arkun A, Brodsky M, Ondo WG, Hunter CB, Jimenez-Shahed J, Palao A, Miyasaki JM, So J, Tetrud J, Reys L, Smith K, Singer C, Blenke A, Russell DS, Cotto C, Friedman JH, Lannon M, Zhang L, Drasby E, Kumar R, Subramanian T, Ford DS, Grimes DA, Cote D, Conway J, Siderowf AD, Evatt ML, Sommerfeld B, Lieberman AN, Okun MS, Rodriguez RL, Merritt S, Swartz CL, Martin WR, King P, Stover N, Guthrie S, Watts RL, Ahmed A, Fernandez HH, Winters A, Mari Z, Dawson TM, Dunlop B, Feigin AS, Shannon B, Nirenberg MJ, Ogg M, Ellias SA, Thomas CA, Frei K, Bodis-Wollner I, Glazman S, Mayer T, Hauser RA, Pahwa R, Langhammer A, Ranawaya R, Derwent L, Sethi KD, Farrow B, Prakash R, Litvan I, Robinson A, Sahay A, Gartner M, Hinson VK, Markind S, Pelikan M, Perlmutter JS, Hartlein J, Molho E, Evans S, Adler CH, Duffy A, Lind M, Elmer L, Davis K, Spears J, Wilson S, Leehey MA, Hermanowicz N, Niswonger S, Shill HA, Obradov S, Rajput A, Cowper M, Lessig S, Song D, Fontaine D, Zadikoff C, Williams K, Blindauer KA, Bergholte J, Propsom CS, Stacy MA, Field J, Mihaila D, Chilton M, Uc EY, Sieren J, Simon DK, Kraics L, Silver A, Boyd JT, Hamill RW, Ingvoldstad C, Young J, Thomas K, Kostyk SK, Wojcieszek J, Pfeiffer RF, Panisset M, Beland M, Reich SG, Cines M, Zappala N, Rivest J, Zweig R, Lumina LP, Hilliard CL, Grill S, Kellermann M, Tuite P, Rolandelli S, Kang UJ, Young J, Rao J, Cook MM, Severt L, Boyar K. "A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit." JAMA neurology.. 2014 May; 71(5):543-52.
2014 Feb
, Schwarzschild MA, Ascherio A, Beal MF, Cudkowicz ME, Curhan GC, Hare JM, Hooper DC, Kieburtz KD, Macklin EA, Oakes D, Rudolph A, Shoulson I, Tennis MK, Espay AJ, Gartner M, Hung A, Bwala G, Lenehan R, Encarnacion E, Ainslie M, Castillo R, Togasaki D, Barles G, Friedman JH, Niles L, Carter JH, Murray M, Goetz CG, Jaglin J, Ahmed A, Russell DS, Cotto C, Goudreau JL, Russell D, Parashos SA, Ede P, Saint-Hilaire MH, Thomas CA, James R, Stacy MA, Johnson J, Gauger L, Antonelle de Marcaida J, Thurlow S, Isaacson SH, Carvajal L, Rao J, Cook M, Hope-Porche C, McClurg L, Grasso DL, Logan R, Orme C, Ross T, Brocht AF, Constantinescu R, Sharma S, Venuto C, Weber J, Eaton K. "Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial." JAMA neurology.. 2014 Feb; 71(2):141-50.
2013 Oct
Oakes D. "An introduction to survival models: in honor of Ross Prentice." Lifetime data analysis. 2013 Oct; 19(4):442-62. Epub 2013 Jul 06.
2013 May 28
"Characterization of the Huntington intermediate CAG repeat expansion phenotype in PHAROS." Neurology.. 2013 May 28; 80(22):2022-7. Epub 2013 Apr 26.

Current Appointments

Professor - Department of Biostatistics and Computational Biology (SMD) - Primary
Professor - Department of Statistics A&S (RC)


PhD | Arts & Sciences | UK - Non-Medical School1972
BA | Arts & Sciences | UK - Non-Medical School1968