Kelley Suzanne Madden, Ph.D.

Kelley Suzanne Madden, Ph.D.

Contact Information

University of Rochester
500 Joseph C. Wilson Blvd.
Box 270168
Rochester, NY 14611

Office: (585) 273-5724

Research Bio

Women diagnosed with breast cancer experience considerable psychological stress, but the impact of such stress on tumor progression is not well understood. The overall objective of my research is to identify mechanisms whereby neurohormones released with stress exposure interact with tumor cells and non-tumor stromal cell populations to regulate cancer progression. Our laboratory has discovered that elevated norepinephrine or activation of selective adrenergic receptors can promote tumor progression and metastasis in association with altered fibrillar collagen microstructure, as detected optically in the tumor by multiphoton second harmonic generation (SHG) imaging.

One goal of this line of investigation is to determine if stress-induced elevation in metastatic potential can be detect by SHG imaging of the tumor extracellular environment. We have also begun to investigate the novel idea that psychological stress exposure promotes metastasis by modulating tumor release of exosomes, a newly discovered mechanism to promote tumor cell metastasis. Ultimately, this research will lead to new therapeutic options in treating breast cancer patients.

Recent Journal Articles

Showing the 5 most recent journal articles. 28 available »

2013 Aug
Burke RM, Madden KS, Perry SW, Zettel ML, Brown EB. "Tumor-associated macrophages and stromal TNF-? regulate collagen structure in a breast tumor model as visualized by second harmonic generation." Journal of biomedical optics. 2013 Aug; 18(8):86003.
2013 Mar
Madden KS, Szpunar MJ, Brown EB. "Early impact of social isolation and breast tumor progression in mice." Brain, behavior, and immunity. 2013 Mar; 30 Suppl:S135-41. Epub 2012 May 17.
2013
Thyagarajan S, Madden KS, Boehm GW, Stevens SY, Felten DL, Bellinger DL. "L-Deprenyl reverses age-associated decline in splenic norepinephrine, interleukin-2 and interferon-? production in old female F344 rats." Neuroimmunomodulation. 2013 20(2):72-8. Epub 2012 Nov 29.
2013
Szpunar MJ, Burke KA, Dawes RP, Brown EB, Madden KS. "The antidepressant desipramine and ?2-adrenergic receptor activation promote breast tumor progression in association with altered collagen structure." Cancer prevention research. 2013 6(12):1262-72.
2011 Apr
ThyagaRajan S, Madden KS, Teruya B, Stevens SY, Felten DL, Bellinger DL. "Age-associated alterations in sympathetic noradrenergic innervation of primary and secondary lymphoid organs in female Fischer 344 rats." Journal of neuroimmunology. 2011 Apr; 233(1-2):54-64. Epub 2010 Dec 24.

Current Appointments

Research Associate Professor - Department of Biomedical Engineering (SMD) - Primary

Education

PhD | Microbiology | Univ Rochester Sch Med/Dent1989
BS | Biology | Valparaiso University1983

Post-Doctoral Training & Residency

University of Rochester, Rochester, New York Department of Neurobiology and Anatomy Postdoctoral Fellow in Psychoneuroimmunology 1992