Research Bio
Dr. McGrath's research interests are:
1) Red Blood Cell transcriptome and development (Erythroid progenitor cells)
2) Blood development in the murine embryo
3) Developmental Biology
4) Molecular Biology.
Her research interest is based on a fundamental curiosity about how cells decide which fate to adopt as embryos develop. Simplistically, this involves a dynamic interplay between the potential each cell has and the signals that it receives that narrow that potential into specific fates. As part of Jim Palis' research group, she applies that paradigm to the development of the blood system in the mouse embryo.
Recently, Dr. McGrath has focused on the initial appearance of the linked fates of blood and vascular systems in the embryo and roles of signaling systems active at the time and place of these initial fate choices (e.g. Notch, BMP and Wnt signaling systems). She has also begun to examine the genetic control of later steps in the maturation of specific lineages within the blood system in the embryo versus the adult utilizing cell sorting technologies.
2013 Feb 7
Kingsley PD, Greenfest-Allen E, Frame JM, Bushnell TP, Malik J, McGrath KE, Stoeckert CJ, Palis J. "Ontogeny of erythroid gene expression." Blood. 2013 Feb 7; 121(6):e5-e13. Epub 2012 Dec 12. |
2013 Feb
Porter RL, Georger M, Bromberg O, McGrath KE, Frisch BJ, Becker MW, Calvi LM. "Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury." Stem cells (Dayton, Ohio). 2013 Feb 0; 31(2):372-83. |
2012 Sep 20
Peslak SA, Wenger J, Bemis JC, Kingsley PD, Koniski AD, McGrath KE, Palis J. "EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress." Blood. 2012 Sep 20; 120(12):2501-11. Epub 2012 Aug 13. |
2011 May 12
Fromm G, Cadiz-Rivera B, de Vries C, Getman M, McGrath KE, Kingsley PD, Fields J, Fiering S, Bulger M. "An embryonic stage-specific enhancer within the murine ?-globin locus mediates domain-wide histone hyperacetylation." Blood. 2011 May 12; 117(19):5207-14. Epub 2011 Feb 14. |
2011 Apr 28
McGrath KE, Frame JM, Fromm GJ, Koniski AD, Kingsley PD, Little J, Bulger M, Palis J. "A transient definitive erythroid lineage with unique regulation of the ?-globin locus in the mammalian embryo." Blood. 2011 Apr 28; 117(17):4600-8. Epub 2011 Mar 04. |
