William H. Merigan, Ph.D.

William H. Merigan, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 314
Rochester, NY 14642

Office: (585) 275-4872

Lab Information

Merigan Lab

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Professional Bio

Dr. Merigan's research examines the role of retinal ganglion cells in visual perception in the primate (human and macaque). The primate retina contains at least 14 different types of retinal ganglion cells, and each type forms a complete network across the retina. Because the size, shape andprojections of each of the cell types is distinctive, it is thought that they may play quite different and possibly independent roles invisual function,but at present relatively little is known about this question.

Some clues about possible functions of different ganglion cell classes comes from their structure (some extend across large swaths of retina, while others get input from tiny regions of retina), their physiology (some ganglion cells respond to color, while others are color blind), and their projections into the brain (some ganglion cells project to visual cortex while others reach the superchiasmatic nucleus, which is thought to be important in diurnal rhythms).

Recent Journal Articles

Showing the 5 most recent journal articles. 51 available »

2011 Mar
Rossi EA, Chung M, Dubra A, Hunter JJ, Merigan WH, Williams DR. "Imaging retinal mosaics in the living eye." Eye (London, England). 2011 Mar; 25(3):301-8.
2009 Mar
Morgan JI, Dubra A, Wolfe R, Merigan WH, Williams DR. "In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic." Investigative ophthalmology & visual science.. 2009 Mar; 50(3):1350-9. Epub 2008 Oct 24.
2009 Mar
Mitsuyasu RT, Merigan TC, Carr A, Zack JA, Winters MA, Workman C, Bloch M, Lalezari J, Becker S, Thornton L, Akil B, Khanlou H, Finlayson R, McFarlane R, Smith DE, Garsia R, Ma D, Law M, Murray JM, von Kalle C, Ely JA, Patino SM, Knop AE, Wong P, Todd AV, Haughton M, Fuery C, Macpherson JL, Symonds GP, Evans LA, Pond SM, Cooper DA. "Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells." Nature medicine.. 2009 Mar; 15(3):285-92. Epub 2009 Feb 15.
2009
Morgan JI, Hunter JJ, Merigan WH, Williams DR. "The reduction of retinal autofluorescence caused by light exposure." Investigative ophthalmology & visual science.. 2009 50(12):6015-22. Epub 2009 Jul 23.
2009
Scoles D, Gray DC, Hunter JJ, Wolfe R, Gee BP, Geng Y, Masella BD, Libby RT, Russell S, Williams DR, Merigan WH. "In-vivo imaging of retinal nerve fiber layer vasculature: imaging histology comparison." BMC ophthalmology. 2009 9:9. Epub 2009 Aug 23.

Current Appointments

Professor - Department of Ophthalmology (SMD) - Primary

Education

PhD | Psychology, All Other | Univ of Maryland1975
MS | Psychology | Univ of Maryland1972
BA | Psychology | Boston College1967