Mahin D. Maines, Ph.D.

Mahin D. Maines, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Office: (585) 275-5383
Fax: (585) 275-6007

Journal Articles

Showing all 186 journal articles available.

2010 Sep
Gibbs PE, Miralem T, Maines MD. "Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 Sep; 24(9):3239-54. Epub 2010 Apr 21.
2009
Kapitulnik, J.; Maines, M. D.;. "Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin". Trends Pharmacol Sci. 2009; 30(33): 129-137. Link
2008
Tudor, C.; Lerner-Marmarosh, N.; Engelborghs, Y.; Gibbs, P. E.; Maines, M. D.;. "Biliverdin reductase is a transporter of heme into the nucleus and is essential to regulation of HO-1 gene expression by hematin". Biochem J. 2008; . Link
2008
Lerner-Marmarosh, N.; Miralem, T.; Gibbs, P. E.; Maines, M. D.;. "Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling". Proc Natl Acad Sci U S A. 2008; 105(319): 6870-5. Link
2007 Mar 16
Maines MD, Miralem T, Lerner-Marmarosh N, Shen J, Gibbs PE. "Human biliverdin reductase, a previously unknown activator of protein kinase C betaII." The Journal of biological chemistry. 2007 Mar 16; 282(11):8110-22. Epub 2007 Jan 16.
2007
Gibbs PE, Maines MD. "Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase." International journal of cancer. Journal international du cancer. 2007 121(11):2567-74.
2007
Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD. "Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2007 21(14):3949-62. Epub 2007 Jul 17.
2006 Apr
Ewing JF, Maines MD. "Regulation and expression of heme oxygenase enzymes in aged-rat brain: age related depression in HO-1 and HO-2 expression and altered stress-response." Journal of neural transmission. 2006 Apr; 113(4):439-54. Epub 2006 Feb 16.
2006
Calabrese V, Maines MD. "Antiaging medicine: antioxidants and aging." Antioxidants & redox signaling. 2006 8(3-4):362-4.
2006
Calabrese V, Butterfield DA, Scapagnini G, Stella AM, Maines MD. "Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity." Antioxidants & redox signaling. 2006 8(3-4):444-77.
2005 May 17
Lerner-Marmarosh N, Shen J, Torno MD, Kravets A, Hu Z, Maines MD. "Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity." Proceedings of the National Academy of Sciences of the United States of America. 2005 May 17; 102(20):7109-14. Epub 2005 May 03.
2005 Apr 29
Miralem T, Hu Z, Torno MD, Lelli KM, Maines MD. "Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells." The Journal of biological chemistry. 2005 Apr 29; 280(17):17084-92. Epub 2005 Feb 28.
2005
Maines MD, Gibbs PE. "30 some years of heme oxygenase: from a "molecular wrecking ball" to a "mesmerizing" trigger of cellular events." Biochemical and biophysical research communications. 2005 338(1):568-77. Epub 2005 Aug 24.
2005
Maines MD. "New insights into biliverdin reductase functions: linking heme metabolism to cell signaling." Physiology (Bethesda, Md.). 2005 20:382-9.
2005
Maines MD. "The heme oxygenase system: update 2005." Antioxidants & redox signaling. 2005 7(11-12):1761-6.
2004 Oct
Maines MD. "The heme oxygenase system: past, present, and future." Antioxidants & redox signaling. 2004 Oct; 6(5):797-801.
2004 May 7
Kravets A, Hu Z, Miralem T, Torno MD, Maines MD. "Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1." The Journal of biological chemistry. 2004 May 7; 279(19):19916-23. Epub 2004 Feb 25.
2003 Jul
Mayer RD, Wang X, Maines MD. "Nitric oxide inhibitor N omega -nitro-l-arginine methyl ester potentiates induction of heme oxygenase-1 in kidney ischemia/reperfusion model: a novel mechanism for regulation of the oxygenase." The Journal of pharmacology and experimental therapeutics. 2003 Jul; 306(1):43-50. Epub 2003 Apr 03.
2003 Feb 7
Wang X, Hauptmann N, Taylor E, Foreman M, Khawli LA, Maines MD. "Neotrofin increases heme oxygenase-1 selectively in neurons." Brain research. 2003 Feb 7; 962(1-2):1-14.
2003 Jan
Maines MD. "Bile pigments: newcomers to the cell signaling arena." Toxicological sciences : an official journal of the Society of Toxicology. 2003 Jan; 71(1):9-10.
2002 Jun 21
Whitby FG, Phillips JD, Hill CP, McCoubrey W, Maines MD. "Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex." Journal of molecular biology. 2002 Jun 21; 319(5):1199-210.
2002 Mar 15
Ahmad Z, Salim M, Maines MD. "Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress." The Journal of biological chemistry. 2002 Mar 15; 277(11):9226-32. Epub 2001 Dec 31.
2002
Maines, M.D.; Panahian, N.;. "The heme oxygenase system and cellular defense mechanisms: Do HO-1 and HO-2 have different functions? Hypoxia from Genese to the Bedside". Advances in Experimental Medicine and Biology (Roach, R.C., Wagner, P.G., Hackett, P.H. eds.) Kluwer Academic/Plenum Pub., New York. 2002; 502(3): 249-271. Link
2002
Maines MD. "Heme oxygenase 1 transgenic mice as a model to study neuroprotection." Methods in enzymology. 2002 353:374-88.
2001 Aug
Huang TJ, McCoubrey WK, Maines MD. "Heme oxygenase-2 interaction with metalloporphyrins: function of heme regulatory motifs." Antioxidants & redox signaling. 2001 Aug; 3(4):685-96.
2001 Apr 6
Salim M, Brown-Kipphut BA, Maines MD. "Human biliverdin reductase is autophosphorylated, and phosphorylation is required for bilirubin formation." The Journal of biological chemistry. 2001 Apr 6; 276(14):10929-34. Epub 2001 Jan 17.
2001 Mar
Maines MD, Ewing JF, Huang TJ, Panahian N. "Nuclear localization of biliverdin reductase in the rat kidney: response to nephrotoxins that induce heme oxygenase-1." The Journal of pharmacology and experimental therapeutics. 2001 Mar; 296(3):1091-7.
2001 Jan
Panahian N, Maines MD. "Site of injury-directed induction of heme oxygenase-1 and -2 in experimental spinal cord injury: differential functions in neuronal defense mechanisms?" Journal of neurochemistry. 2001 Jan; 76(2):539-54.
2001
Maines MD, Panahian N. "The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions?" Advances in experimental medicine and biology. 2001 502:249-72.
2000 Nov
Panahian N, Maines MD. "Assessment of induction of biliverdin reductase in a mouse model of middle cerebral artery occlusion." Brain research. Brain research protocols. 2000 Nov; 6(1-2):53-70.
2000 Jul
Chen K, Gunter K, Maines MD. "Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death." Journal of neurochemistry. 2000 Jul; 75(1):304-13.
2000 May
Maines MD. "The heme oxygenase system and its functions in the brain." Cellular and molecular biology (Noisy-le-Grand, France). 2000 May; 46(3):573-85.
2000 May
Chen K, Maines MD. "Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38." Cellular and molecular biology (Noisy-le-Grand, France). 2000 May; 46(3):609-17.
2000 Jan 4
Liu N, Wang X, McCoubrey WK, Maines MD. "Developmentally regulated expression of two transcripts for heme oxygenase-2 with a first exon unique to rat testis: control by corticosterone of the oxygenase protein expression." Gene. 2000 Jan 4; 241(1):175-83.
1999 Nov
Maines MD, Raju VS, Panahian N. "Spin trap (N-t-butyl-alpha-phenylnitrone)-mediated suprainduction of heme oxygenase-1 in kidney ischemia/reperfusion model: role of the oxygenase in protection against oxidative injury." The Journal of pharmacology and experimental therapeutics. 1999 Nov; 291(2):911-9.
1999 Oct
Maines MD, Mayer RD, Erturk E, Huang TJ, Disantagnese A. "The oxidoreductase, biliverdin reductase, is induced in human renal carcinoma--pH and cofactor-specific increase in activity." The Journal of urology. 1999 Oct; 162(4):1467-72.
1999 Sep
Ding Y, McCoubrey WK, Maines MD. "Interaction of heme oxygenase-2 with nitric oxide donors. Is the oxygenase an intracellular 'sink' for NO?" European journal of biochemistry. 1999 Sep; 264(3):854-61.
1999 Mar
Panahian N, Yoshiura M, Maines MD. "Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice." Journal of neurochemistry. 1999 Mar; 72(3):1187-203.
1999
Panahian N, Huang T, Maines MD. "Enhanced neuronal expression of the oxidoreductase--biliverdin reductase--after permanent focal cerebral ischemia." Brain research. 1999 850(1-2):1-13.
1998 Oct 12
Morgan D, Holcomb L, Saad I, Gordon M, Mahin Maines . "Impaired spatial navigation learning in transgenic mice over-expressing heme oxygenase-1." Brain research. 1998 Oct 12; 808(1):110-2.
1998 Jun
Woo J, Iyer S, Cornejo MC, Mori N, Gao L, Sipos I, Maines M, Buelow R. "Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32)." Transplant immunology. 1998 Jun; 6(2):84-93.
1998 May
Maines MD, Polevoda B, Coban T, Johnson K, Stoliar S, Huang TJ, Panahian N, Cory-Slechta DA, McCoubrey WK. "Neuronal overexpression of heme oxygenase-1 correlates with an attenuated exploratory behavior and causes an increase in neuronal NADPH diaphorase staining." Journal of neurochemistry. 1998 May; 70(5):2057-69.
1998 Feb
Miller SM, Farrugia G, Schmalz PF, Ermilov LG, Maines MD, Szurszewski JH. "Heme oxygenase 2 is present in interstitial cell networks of the mouse small intestine." Gastroenterology. 1998 Feb; 114(2):239-44.
1998 Feb
Farrugia G, Miller SM, Rich A, Liu X, Maines MD, Rae JL, Szurszewski JH. "Distribution of heme oxygenase and effects of exogenous carbon monoxide in canine jejunum." The American journal of physiology. 1998 Feb; 274(2 Pt 1):G350-8.
1998 Jan 30
Iyer S, Woo J, Cornejo MC, Gao L, McCoubrey W, Maines M, Buelow R. "Characterization and biological significance of immunosuppressive peptide D2702.75-84(E --> V) binding protein. Isolation of heme oxygenase-1." The Journal of biological chemistry. 1998 Jan 30; 273(5):2692-7.
1997 Jul 15
McCoubrey WK, Huang TJ, Maines MD. "Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3." European journal of biochemistry. 1997 Jul 15; 247(2):725-32.
1997 May 9
McCoubrey WK, Huang TJ, Maines MD. "Heme oxygenase-2 is a hemoprotein and binds heme through heme regulatory motifs that are not involved in heme catalysis." The Journal of biological chemistry. 1997 May 9; 272(19):12568-74.
1997 May
Lagarias DM, Crepeau MW, Maines MD, Lagarias JC. "Regulation of photomorphogenesis by expression of mammalian biliverdin reductase in transgenic Arabidopsis plants." The Plant cell. 1997 May; 9(5):675-88.
1997 May
Ewing JF, Maines MD. "Histochemical localization of heme oxygenase-2 protein and mRNA expression in rat brain." Brain research. Brain research protocols. 1997 May; 1(2):165-74.
1997 Mar 20
Raju VS, McCoubrey WK, Maines MD. "Regulation of heme oxygenase-2 by glucocorticoids in neonatal rat brain: characterization of a functional glucocorticoid response element." Biochimica et biophysica acta. 1997 Mar 20; 1351(1-2):89-104.
1997
Ewing, J.F.; Maines, M.D.;. "The heme oxygenase system and carbon monoxide production: A non-radical approach to cell signaling". Porphyrins. 1997; 6(3): 1-13. Link
1997
Maines MD. "The heme oxygenase system: a regulator of second messenger gases." Annual review of pharmacology and toxicology. 1997 37:517-54.
1996 Jun 7
Geddes JW, Pettigrew LC, Holtz ML, Craddock SD, Maines MD. "Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase-2, protein in rat brain." Neuroscience letters. 1996 Jun 7; 210(3):205-8.
1996 Jun
Raju VS, Maines MD. "Renal ischemia/reperfusion up-regulates heme oxygenase-1 (HSP32) expression and increases cGMP in rat heart." The Journal of pharmacology and experimental therapeutics. 1996 Jun; 277(3):1814-22.
1996 May 25
Maines MD, Eke BC, Zhao X. "Corticosterone promotes increased heme oxygenase-2 protein and transcript expression in the newborn rat brain." Brain research. 1996 May 25; 722(1-2):83-94.
1996 May
Maines MD, Abrahamsson PA. "Expression of heme oxygenase-1 (HSP32) in human prostate: normal, hyperplastic, and tumor tissue distribution." Urology. 1996 May; 47(5):727-33.
1996 May
Maines MD, Ewing JF. "Stress response of the rat testis: in situ hydridization and immunohistochemical analysis of heme oxygenase-1 (HSP32) induction by hyperthermia." Biology of reproduction. 1996 May; 54(5):1070-9.
1996 Jan 15
Maines MD, Polevoda BV, Huang TJ, McCoubrey WK. "Human biliverdin IXalpha reductase is a zinc-metalloprotein. Characterization of purified and Escherichia coli expressed enzymes." European journal of biochemistry. 1996 Jan 15; 235(1-2):372-81.
1996
Maines M. "Carbon monoxide and nitric oxide homology: differential modulation of heme oxygenases in brain and detection of protein and activity." Methods in enzymology. 1996 268:473-88.
1995 Jul 28
McCoubrey WK, Cooklis MA, Maines MD. "The structure, organization and differential expression of the rat gene encoding biliverdin reductase." Gene. 1995 Jul 28; 160(2):235-40.
1995 May
Ewing JF, Maines MD. "Distribution of constitutive (HO-2) and heat-inducible (HO-1) heme oxygenase isozymes in rat testes: HO-2 displays stage-specific expression in germ cells." Endocrinology. 1995 May; 136(5):2294-302.
1995 Apr
Maines MD, Eke BC, Weber CM, Ewing JF. "Corticosterone has a permissive effect on expression of heme oxygenase-1 in CA1-CA3 neurons of hippocampus in thermal-stressed rats." Journal of neurochemistry. 1995 Apr; 64(4):1769-79.
1995 Feb 20
Ewing JF, Maines MD. "Immunohistochemical localization of biliverdin reductase in rat brain: age related expression of protein and transcript." Brain research. 1995 Feb 20; 672(1-2):29-41.
1995
McCoubrey WK, Eke B, Maines MD. "Multiple transcripts encoding heme oxygenase-2 in rat testis: developmental and cell-specific regulation of transcripts and protein." Biology of reproduction. 1995 53(6):1330-8.
1994 Nov
Vincent SR, Das S, Maines MD. "Brain heme oxygenase isoenzymes and nitric oxide synthase are co-localized in select neurons." Neuroscience. 1994 Nov; 63(1):223-31.
1994 Oct 21
Rublevskaya I, Maines MD. "Interaction of Fe-protoporphyrin IX and heme analogues with purified recombinant heme oxygenase-2, the constitutive isozyme of the brain and testes." The Journal of biological chemistry. 1994 Oct 21; 269(42):26390-5.
1994 Oct
Ewing JF, Raju VS, Maines MD. "Induction of heart heme oxygenase-1 (HSP32) by hyperthermia: possible role in stress-mediated elevation of cyclic 3':5'-guanosine monophosphate." The Journal of pharmacology and experimental therapeutics. 1994 Oct; 271(1):408-14.
1994 Sep
Weber CM, Eke BC, Maines MD. "Corticosterone regulates heme oxygenase-2 and NO synthase transcription and protein expression in rat brain." Journal of neurochemistry. 1994 Sep; 63(3):953-62.
1994 Jun 1
McCoubrey WK, Maines MD. "Site-directed mutagenesis of cysteine residues in biliverdin reductase. Roles in substrate and cofactor binding." European journal of biochemistry. 1994 Jun 1; 222(2):597-603.
1994 Apr 6
Raju VS, Maines MD. "Coordinated expression and mechanism of induction of HSP32 (heme oxygenase-1) mRNA by hyperthermia in rat organs." Biochimica et biophysica acta. 1994 Apr 6; 1217(3):273-80.
1994 Feb 25
McCoubrey WK, Maines MD. "The structure, organization and differential expression of the gene encoding rat heme oxygenase-2." Gene. 1994 Feb 25; 139(2):155-61.
1993 Oct
Maines MD. "Carbon Monoxide: An Emerging Regulator of cGMP in the Brain." Molecular and cellular neurosciences. 1993 Oct; 4(5):389-97.
1993 Oct
Maines MD, Mark JA, Ewing JF. "Heme Oxygenase, a Likely Regulator of cGMP Production in the Brain: Induction in Vivo of HO-1 Compensates for Depression in NO Synthase Activity." Molecular and cellular neurosciences. 1993 Oct; 4(5):396-405.
1993 Sep
Ewing JF, Weber CM, Maines MD. "Biliverdin reductase is heat resistant and coexpressed with constitutive and heat shock forms of heme oxygenase in brain." Journal of neurochemistry. 1993 Sep; 61(3):1015-23.
1993 May
McCoubrey WK, Maines MD. "Domains of rat heme oxygenase-2: the amino terminus and histidine 151 are required for heme oxidation." Archives of biochemistry and biophysics. 1993 May; 302(2):402-8.
1993 Apr
Ewing JF, Maines MD. "Glutathione depletion induces heme oxygenase-1 (HSP32) mRNA and protein in rat brain." Journal of neurochemistry. 1993 Apr; 60(4):1512-9.
1993 Jan
Maines MD, Mayer RD, Ewing JF, McCoubrey WK. "Induction of kidney heme oxygenase-1 (HSP32) mRNA and protein by ischemia/reperfusion: possible role of heme as both promotor of tissue damage and regulator of HSP32." The Journal of pharmacology and experimental therapeutics. 1993 Jan; 264(1):457-62.
1993 Jan
Maines MD, Trakshel GM. "Purification and characterization of human biliverdin reductase." Archives of biochemistry and biophysics. 1993 Jan; 300(1):320-6.
1993
Terry MJ, Maines MD, Lagarias JC. "Inactivation of phytochrome- and phycobiliprotein-chromophore precursors by rat liver biliverdin reductase." The Journal of biological chemistry. 1993 268(35):26099-106.
1993
Maines, M.D.; Mark, J.; Ewing, J.;. "Heme oxygenase, a likely regulator of cGMP production in the brain: induction in vivo of HO-1 compensates for depression in NO synthase activity". Molecular and Cellular Neuroscience. 1993; 4(3): 398-405. Link
1993
Maines, M.D.;. "Carbon Monoxide: An emerging regulator of cGMP in the brain (invited review)". Molecular and Cellular Neuroscience. 1993; 4(3): 389-397. Link
1992 Sep
Mark JA, Maines MD. "Tin-protoporphyrin-mediated disruption in vivo of heme oxygenase-2 protein integrity and activity in rat brain." Pediatric research. 1992 Sep; 32(3):324-9.
1992 Jun 15
Maines MD, Trakshel GM. "Differential regulation of heme oxygenase isozymes by Sn- and Zn-protoporphyrins: possible relevance to suppression of hyperbilirubinemia." Biochimica et biophysica acta. 1992 Jun 15; 1131(2):166-74.
1992 May 15
McCoubrey WK, Ewing JF, Maines MD. "Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal." Archives of biochemistry and biophysics. 1992 May 15; 295(1):13-20.
1992 Mar
Ewing JF, Haber SN, Maines MD. "Normal and heat-induced patterns of expression of heme oxygenase-1 (HSP32) in rat brain: hyperthermia causes rapid induction of mRNA and protein." Journal of neurochemistry. 1992 Mar; 58(3):1140-9.
1992 Feb 25
Fakhrai H, Maines MD. "Expression and characterization of a cDNA for rat kidney biliverdin reductase. Evidence suggesting the liver and kidney enzymes are the same transcript product." The Journal of biological chemistry. 1992 Feb 25; 267(6):4023-9.
1992 Feb
Maines MD, Trakshel GM. "Tin-protoporphyrin: a potent inhibitor of hemoprotein-dependent steroidogenesis in rat adrenals and testes." The Journal of pharmacology and experimental therapeutics. 1992 Feb; 260(2):909-16.
1992 Feb
Trakshel GM, Sluss PM, Maines MD. "Comparative effects of tin- and zinc-protoporphyrin on steroidogenesis: tin-protoporphyrin is a potent inhibitor of cytochrome P-450-dependent activities in the rat adrenals." Pediatric research. 1992 Feb; 31(2):196-201.
1992
Ewing, J.F.; aines, M.D.;. "In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: differential distribution of isozyme 1 and 2". Molecular and Cellular Neuroscience. 1992; 3(3): 559-570. Link
1992
Ewing JF, Maines MD. "In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: Differential distribution of isozyme 1 and 2." Molecular and cellular neurosciences. 1992 3(6):559-70.
1991 Nov 1
Rotenberg MO, Maines MD. "Characterization of a cDNA-encoding rabbit brain heme oxygenase-2 and identification of a conserved domain among mammalian heme oxygenase isozymes: possible heme-binding site?" Archives of biochemistry and biophysics. 1991 Nov 1; 290(2):336-44.
1991 Nov
Krueger BA, Trakshel GM, Sluss PM, Maines MD. "Cyclosporin-mediated depression of luteinizing hormone receptors and heme biosynthesis in rat testes: a possible mechanism for decrease in serum testosterone." Endocrinology. 1991 Nov; 129(5):2647-54.
1991 Aug 1
Saunders EL, Maines MD, Meredith MJ, Freeman ML. "Enhancement of heme oxygenase-1 synthesis by glutathione depletion in Chinese hamster ovary cells." Archives of biochemistry and biophysics. 1991 Aug 1; 288(2):368-73.
1991 Jun 15
Ewing JF, Maines MD. "Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein." Proceedings of the National Academy of Sciences of the United States of America. 1991 Jun 15; 88(12):5364-8.
1991 Apr 1
Trakshel GM, Ewing JF, Maines MD. "Heterogeneity of haem oxygenase 1 and 2 isoenzymes. Rat and primate transcripts for isoenzyme 2 differ in number and size." The Biochemical journal. 1991 Apr 1; 275 ( Pt 1):159-64.
1990 Nov 1
Sun Y, Maines MD. "Heme oxygenase-2 mRNA: developmental expression in the rat liver and response to cobalt chloride." Archives of biochemistry and biophysics. 1990 Nov 1; 282(2):340-5.
1990 Oct
Maines MD. "Multiple forms of biliverdin reductase: age-related change in pattern of expression in rat liver and brain." Molecular pharmacology. 1990 Oct; 38(4):481-5.
1990 Jun 29
Iscan M, Reuhl K, Weiss B, Maines MD. "Regional and subcellular distribution of cytochrome P-450-dependent drug metabolism in monkey brain: the olfactory bulb and the mitochondrial fraction have high levels of activity." Biochemical and biophysical research communications. 1990 Jun 29; 169(3):858-63.
1990 May 15
Sun Y, Rotenberg MO, Maines MD. "Developmental expression of heme oxygenase isozymes in rat brain. Two HO-2 mRNAs are detected." The Journal of biological chemistry. 1990 May 15; 265(14):8212-7.
1990 May 15
Mayer RD, Maines MD. "Promotion of trans-platinum in vivo effects on renal heme and hemoprotein metabolism by D,L-buthionine-S,R-sulfoximine. Possible role of glutathione." Biochemical pharmacology. 1990 May 15; 39(10):1565-71.
1990 May 5
Rotenberg MO, Maines MD. "Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2." The Journal of biological chemistry. 1990 May 5; 265(13):7501-6.
1990 May
Maines MD, Sluss PM, Iscan M. "cis-platinum-mediated decrease in serum testosterone is associated with depression of luteinizing hormone receptors and cytochrome P-450scc in rat testis." Endocrinology. 1990 May; 126(5):2398-406.
1990 Apr
Iscan M, Maines MD. "Differential regulation of heme and drug metabolism in rat testis and prostate: response to cis-platinum and human chorionic gonadotropin." The Journal of pharmacology and experimental therapeutics. 1990 Apr; 253(1):73-9.
1990 Jan
Huang TJ, Maines MD. "Bromobenzene-mediated alteration in activity and electrophoretic pattern of biliverdin reductase variants in rat kidney." Molecular pharmacology. 1990 Jan; 37(1):25-9.
1990
Maines MD. "Effect of cis-platinum on heme, drug, and steroid metabolism pathways: possible involvement in nephrotoxicity and infertility." Critical reviews in toxicology. 1990 21(1):1-20.
1989 Nov 1
Huang TJ, Trakshel GM, Maines MD. "Microheterogeneity of biliverdin reductase in rat liver and spleen: selective suppression of enzyme variants in liver by bromobenzene." Archives of biochemistry and biophysics. 1989 Nov 1; 274(2):617-25.
1989 May 15
Huang TJ, Trakshel GM, Maines MD. "Detection of 10 variants of biliverdin reductase in rat liver by two-dimensional gel electrophoresis." The Journal of biological chemistry. 1989 May 15; 264(14):7844-9.
1989 May 1
Huang TJ, Trakshel GM, Maines MD. "Multiple forms of biliverdin reductase: modification of the pattern of expression in rat liver by bromobenzene." Archives of biochemistry and biophysics. 1989 May 1; 270(2):513-20.
1989 Mar 15
Mayer RD, Berman S, Cockett AT, Maines MD. "Differential effects of cyclosporin on hepatic and renal heme, cytochrome P-450 and drug metabolism. Possible role in nephrotoxicity of the drug." Biochemical pharmacology. 1989 Mar 15; 38(6):1001-7.
1989 Jan 15
Trakshel GM, Maines MD. "Multiplicity of heme oxygenase isozymes. HO-1 and HO-2 are different molecular species in rat and rabbit." The Journal of biological chemistry. 1989 Jan 15; 264(2):1323-8.
1989 Jan
Kutty RK, Maines MD. "Selective induction of heme oxygenase-1 isozyme in rat testis by human chorionic gonadotropin." Archives of biochemistry and biophysics. 1989 Jan; 268(1):100-7.
1989 Jan
Liccione JJ, Maines MD. "Manganese-mediated increase in the rat brain mitochondrial cytochrome P-450 and drug metabolism activity: susceptibility of the striatum." The Journal of pharmacology and experimental therapeutics. 1989 Jan; 248(1):222-8.
1988 Oct
Liccione JJ, Maines MD. "Selective vulnerability of glutathione metabolism and cellular defense mechanisms in rat striatum to manganese." The Journal of pharmacology and experimental therapeutics. 1988 Oct; 247(1):156-61.
1988 Jul 15
Trakshel GM, Maines MD. "Detection of two heme oxygenase isoforms in the human testis." Biochemical and biophysical research communications. 1988 Jul 15; 154(1):285-91.
1988 Jul
Maines MD. "Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1988 Jul; 2(10):2557-68.
1988 May 15
Bell JE, Maines MD. "Kinetic properties and regulation of biliverdin reductase." Archives of biochemistry and biophysics. 1988 May 15; 263(1):1-9.
1988 May 15
Trakshel GM, Maines MD. "Characterization of glutathione S-transferases in rat kidney. Alteration of composition by cis-platinum." The Biochemical journal. 1988 May 15; 252(1):127-36.
1988 Mar 5
Cruse I, Maines MD. "Evidence suggesting that the two forms of heme oxygenase are products of different genes." The Journal of biological chemistry. 1988 Mar 5; 263(7):3348-53.
1988 Feb 1
Kutty RK, Daniel RF, Ryan DE, Levin W, Maines MD. "Rat liver cytochrome P-450b, P-420b, and P-420c are degraded to biliverdin by heme oxygenase." Archives of biochemistry and biophysics. 1988 Feb 1; 260(2):638-44.
1988 Feb 1
Trakshel GM, Kutty RK, Maines MD. "Resolution of the rat brain heme oxygenase activity: absence of a detectable amount of the inducible form (HO-1)." Archives of biochemistry and biophysics. 1988 Feb 1; 260(2):732-9.
1987 Sep 1
Kutty RK, Maines MD. "Characterization of an NADH-dependent haem-degrading system in ox heart mitochondria." The Biochemical journal. 1987 Sep 1; 246(2):467-74.
1987 Sep
Trakshel GM, Rowley PT, Maines MD. "Regulation of the activity of heme degradative enzymes in K562 erythroleukemic cells: induction by thymidine." Experimental hematology. 1987 Sep; 15(8):859-63.
1987 Apr 15
Chung AS, Maines MD. "Differential effect of cadmium on GSH-peroxidase activity in the Leydig and the Sertoli cells of rat testis. Suppression by selenium and the possible relationship to heme concentration." Biochemical pharmacology. 1987 Apr 15; 36(8):1367-72.
1986 Nov 15
Trakshel GM, Kutty RK, Maines MD. "Cadmium-mediated inhibition of testicular heme oxygenase activity: the role of NADPH-cytochrome c (P-450) reductase." Archives of biochemistry and biophysics. 1986 Nov 15; 251(1):175-87.
1986 Sep 1
Veltman JC, Maines MD. "Regulatory effect of copper on rat adrenal cytochrome P-450 and steroid metabolism." Biochemical pharmacology. 1986 Sep 1; 35(17):2903-9.
1986 Aug 25
Trakshel GM, Kutty RK, Maines MD. "Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform." The Journal of biological chemistry. 1986 Aug 25; 261(24):11131-7.
1986 Aug 1
Maines MD. "Differential effect of cis-platinum (cis-diamminedichloroplatinum) on regulation of liver and kidney haem and haemoprotein metabolism. Possible involvement of gamma-glutamyl-cycle enzymes." The Biochemical journal. 1986 Aug 1; 237(3):713-21.
1986 Aug 1
Veltman JC, Maines MD. "Alterations of heme, cytochrome P-450, and steroid metabolism by mercury in rat adrenal." Archives of biochemistry and biophysics. 1986 Aug 1; 248(2):467-78.
1986 Jan 5
Maines MD, Trakshel GM, Kutty RK. "Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible." The Journal of biological chemistry. 1986 Jan 5; 261(1):411-9.
1986
Braggins PE, Trakshel GM, Kutty RK, Maines MD. "Characterization of two heme oxygenase isoforms in rat spleen: comparison with the hematin-induced and constitutive isoforms of the liver." Biochemical and biophysical research communications. 1986 141(2):528-33.
1985 Oct
Veltman JC, Maines MD. "Sex difference in adrenal heme and cytochrome P-450 metabolism: evidence for the repressive regulatory role of testosterone." The Journal of pharmacology and experimental therapeutics. 1985 Oct; 235(1):71-5.
1985 Jul
Jollie DR, Maines MD. "Effect of cis-platinum on kidney cytochrome P-450 and heme metabolism: evidence for the regulatory role of the pituitary hormones." Archives of biochemistry and biophysics. 1985 Jul; 240(1):51-9.
1985 May 25
Maines MD, Mayer RD. "Inhibition of testicular cytochrome P-450-dependent steroid biosynthesis by cis-platinum. Reversal by human chorionic gonadotropin." The Journal of biological chemistry. 1985 May 25; 260(10):6063-8.
1985 Apr 16
Qato MK, Maines MD. "Regulation of heme and drug metabolism activities in the brain by manganese." Biochemical and biophysical research communications. 1985 Apr 16; 128(1):18-24.
1985 Feb 15
Qato MK, Maines MD. "Prevention of neonatal hyperbilirubinaemia in non-human primates by Zn-protoporphyrin." The Biochemical journal. 1985 Feb 15; 226(1):51-7.
1984 Sep 15
Kutty RK, Maines MD. "Effects of induction of heme oxygenase by cobalt and tin on the in vivo degradation of myoglobin." Biochemical pharmacology. 1984 Sep 15; 33(18):2924-6.
1984 Aug 10
Maines MD, Jollie DR. "Dissociation of heme metabolic activities from the microsomal cytochrome P-450 turnover in testis of hypophysectomized rats." The Journal of biological chemistry. 1984 Aug 10; 259(15):9557-62.
1984 Jul 18
Kutty RK, Maines MD. "Hepatic heme metabolism: possible role of biliverdin in the regulation of heme oxygenase activity." Biochemical and biophysical research communications. 1984 Jul 18; 122(1):40-6.
1984 May 1
Maines MD. "Characterization of heme oxygenase activity in Leydig and Sertoli cells of the rat testes. Differential distribution of activity and response to cadmium." Biochemical pharmacology. 1984 May 1; 33(9):1493-502.
1984 Jan 15
Maines MD, Veltman JC. "Phenylhydrazine-mediated induction of haem oxygenase activity in rat liver and kidney and development of hyperbilirubinaemia. Inhibition by zinc-protoporphyrin." The Biochemical journal. 1984 Jan 15; 217(2):409-17.
1984
Maines MD. "New developments in the regulation of heme metabolism and their implications." Critical reviews in toxicology. 1984 12(3):241-314.
1983 Oct 1
Maines MD, Kutty RK. "Differential response of testicular and ovarian heme oxygenase activity to metal ions." Archives of biochemistry and biophysics. 1983 Oct 1; 226(1):134-44.
1983 Jul 1
Kutty RK, Maines MD. "Biliverdin reductase: characterization in the rat kidney and the inhibition of activity by mercuric chloride." Biochemical pharmacology. 1983 Jul 1; 32(13):2095-102.
1982 Oct 1
Chung AS, Maines MD, Reynolds WA. "Inhibition of the enzymes of glutathione metabolism by mercuric chloride in the rat kidney: reversal by selenium." Biochemical pharmacology. 1982 Oct 1; 31(19):3093-100.
1982 Sep 10
Kutty RK, Maines MD. "Oxidation of heme c derivatives by purified heme oxygenase. Evidence for the presence of one molecular species of heme oxygenase in the rat liver." The Journal of biological chemistry. 1982 Sep 10; 257(17):9944-52.
1982 Jun
Maines MD. "Enhancement and inhibition of enzymes of heme metabolism by diethyl maleate in the rat kidney." Archives of biochemistry and biophysics. 1982 Jun; 216(1):17-26.
1982
Maines MD, Chung AS, Kutty RK. "The inhibition of testicular heme oxygenase activity by cadmium. A novel cellular response." The Journal of biological chemistry. 1982 257(23):14116-21.
1981 Sep
Maines MD, Senft AW. "Host heme biosynthesis and degradation in schistosomiasis." The American journal of tropical medicine and hygiene. 1981 Sep; 30(5):1010-9.
1981 Apr 25
Kutty RK, Maines MD. "Purification and characterization of biliverdin reductase from rat liver." The Journal of biological chemistry. 1981 Apr 25; 256(8):3956-62.
1981 Apr 15
Maines MD. "Effect of allylisopropylacetamide on glutathione metabolism in the rat liver. The possible role of glutathione in the induction of 5-aminolaevulinate synthase." The Biochemical journal. 1981 Apr 15; 196(1):285-92.
1981 Mar 18
Maines MD. "Zinc . protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat." Biochimica et biophysica acta. 1981 Mar 18; 673(3):339-50.
1981
Chung AS, Maines MD. "Effect of selenium on glutathione metabolism. Induction of gamma-glutamylcysteine synthetase and glutathione reductase in the rat liver." Biochemical pharmacology. 1981 30(23):3217-23.
1981
Maines MD. "Enzymatic basis of metal ion alterations of cellular heme and glutathione metabolism." Fundamental and applied toxicology : official journal of the Society of Toxicology. 1981 1(5):358-67.
1980 Aug 15
Maines MD. "Regional distribution of the enzymes of haem biosynthesis and the inhibition of 5-aminolaevulinate synthase by manganese in the rat brain." The Biochemical journal. 1980 Aug 15; 190(2):315-21.
1980
Maines MD. "Evidence for the catalytic activity of endogenous iron in the lipid peroxidative destruction of heme by allylisopropylacetamide in the rat liver." The International journal of biochemistry. 1980 12(5-6):781-5.
1979
Maines MD. "Role of trace metals in regulation of cellular heme and hemoprotein metabolism: sensitizing effects of chronic iron treatment on acute gold toxicity." Drug metabolism reviews. 1979 9(2):237-55.
1978 Apr 10
Maines MD, Kappas A. "Prematurely evoked synthesis and induction of delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion repression of enzyme formation." The Journal of biological chemistry. 1978 Apr 10; 253(7):2321-6.
1978
Maines, M.D.; Tomio, J.M.; Janousek, V.;. "Effect of cobalt on enzymes of porphyrin and heme synthesis in the rat kidney and the inhibition by cobalt of 3, 5-dicarbethoxy-1, 4-dihydrocollidine and allyl- isopropyl-acetamide induction of liver d-aminolevulinate synthetase activity". Journal of Clinical Chemistry and Clinical Biochemistry. 1978; 16(3): 30-32. Link
1977 Nov 1
Maines MD, Kappas A. "Enzymes of heme metabolism in the kidney: regulation by trace metals which do not form heme complexes." The Journal of experimental medicine. 1977 Nov 1; 146(5):1286-93.
1977 Nov
Maines MD, Kappas A. "Regulation of cytochrome P-450-dependent microsomal drug-metabolizing enzymes by nickel, cobalt, and iron." Clinical pharmacology and therapeutics. 1977 Nov; 22(5 Pt 2):780-90.
1977 Aug 25
Maines MD, Ibrahim NG, Kappas A. "Solubilization and partial purification of heme oxygenase from rat liver." The Journal of biological chemistry. 1977 Aug 25; 252(16):5900-3.
1977 May
Maines MD, Kappas A. "Regulation of heme pathway enzymes and cellular glutathione content by metals that do not chelate with tetrapyrroles: blockade of metal effects by thiols." Proceedings of the National Academy of Sciences of the United States of America. 1977 May; 74(5):1875-8.
1977 Apr 1
Maines MD, Cohn J. "Bile pigment formation by skin heme oxygenase: studies on the response of the enzyme to heme compounds and tissue injury." The Journal of experimental medicine. 1977 Apr 1; 145(4):1054-9.
1977 Feb 8
Maines MD, Kappas A. "Enzymatic oxidation of cobalt protoporphyrin IX: observations on the mechanism of heme oxygenase action." Biochemistry. 1977 Feb 8; 16(3):419-23.
1977 Jan 10
Maines MD, Sinclair P. "Cobalt regulation of heme synthesis and degradation in avian embryo liver cell culture." The Journal of biological chemistry. 1977 Jan 10; 252(1):219-23.
1977
Maines MD, Kappas A. "Metals as regulators of heme metabolism." Science. 1977 198(4323):1215-21.
1976 May
Maines MD, Janous?k V, Tomio JM, Kappas A. "Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver." Proceedings of the National Academy of Sciences of the United States of America. 1976 May; 73(5):1499-503.
1976 Apr 2
Kappas A, Maines MD. "Tin: a potent inducer of heme oxygenase in kidney." Science. 1976 Apr 2; 192(4234):60-2.
1976 Jan 15
Maines MD, Kappas A. "Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions." The Biochemical journal. 1976 Jan 15; 154(1):125-31.
1976
Maines MD. "Evidence for the catabolism of polychlorinated biphenyl-induced cytochrome P-448 by microsomal heme oxygenase, and the inhibition of delta-aminolevulinate dehydratase by polychlorinated biphenyls." The Journal of experimental medicine. 1976 144(6):1509-19.
1976
Maines, M.D.; Kappas, A.;. "Trace Metal regulation of heme and hemoprotein oxidation". Hoppe-Seyler's Zeitschrift fur Physiologische Chemie. 1976; 357(3): 1038-1039. Link
1976
Maines MD, Kappas A. "Selenium regulation of hepatic heme metabolism: induction of delta-aminolevulinate synthase and heme oxygenase." Proceedings of the National Academy of Sciences of the United States of America. 1976 73(12):4428-31.
1976
Maines MD, Kappas A. "The induction of heme oxidation in various tissues by trace metals: evidence for the catabolism of endogenous heme by hepatic heme oxygenase." Annals of clinical research. 1976 8 Suppl 17:39-46.
1975 Jun 10
Maines MD, Kappas A. "Cobalt stimulation of heme degradation in the liver. Dissociation of microsomal oxidation of heme from cytochrome P-450." The Journal of biological chemistry. 1975 Jun 10; 250(11):4171-7.
1975 Jun 1
Maines MD, Kappas A. "Study of the developmental pattern of heme catabolism in liver and the effects of cobalt on cytochrome P-450 and the rate of heme oxidation during the neonatal period." The Journal of experimental medicine. 1975 Jun 1; 141(6):1400-10.
1975 Mar 25
Maines MD, Kappas A. "The degradative effects of porphyrins and heme compounds on components of the microsomal mixed function oxidase system." The Journal of biological chemistry. 1975 Mar 25; 250(6):2363-9.
1974 Nov
Maines MD, Kappas A. "Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity." Proceedings of the National Academy of Sciences of the United States of America. 1974 Nov; 71(11):4293-7.
1974 Mar
Maines MD, Anders MW, Muller-Eberhard U. "Studies on heme transfer from microsomal hemoproteins to heme-binding plasma proteins." Molecular pharmacology. 1974 Mar; 10(2):204-13.
1973 Nov
Maines MD, Anders MW. "Characterization of the heme of cytochrome P-450 using gas chromatography-mass spectrometry." Archives of biochemistry and biophysics. 1973 Nov; 159(1):201-5.
1973 Mar
Maines MD, Anders MW. "Reconstitution of carbon monoxide-binding particles after removal of heme by serum albumin." Molecular pharmacology. 1973 Mar; 9(2):219-28.
1973
Maines MD, Anders MW. "The possible implication of heme transfer from cytochrome P-420 to albumin in the metabolism of cytochrome P-450." Drug metabolism and disposition : the biological fate of chemicals. 1973 1(1):293-8.
1972 May
Short CR, Maines MD, Davis LE. "Preparation of hepatic microsomal fraction for drug metabolism studies by rapid decompression homogenization." Proceedings of the Society for Experimental Biology and Medicine. 1972 May; 140(1):58-65.
1972
Short CR, Maines MD, Westfall BA. "Postnatal development of drug-metabolizing enzyme activity in liver and extrahepatic tissues of swine." Biology of the neonate. 1972 21(1):54-68.
1971 Sep
Maines MD, Westfall BA. "Effect of water deprivation on the metabolism of hexobarbital in the Mongolian gerbil (Meriones unguiculatus)." Comparative and general pharmacology. 1971 Sep; 2(7):311-6.
1971 Jun
Maines MD, Wosilait WD. "An autoradiographic study of the distribution and excretion of 14C-dicoumarol in the rat." Comparative and general pharmacology. 1971 Jun; 2(6):184-8.
1971
Maines MD, Westfall BA. "Sex difference in the metabolism of hexobarbital in the mongolian gerbil (Meriones unguiculatus)." Proceedings of the Society for Experimental Biology and Medicine. 1971 138(3):820-2.