Philip J. Fay, Ph.D.

Philip J. Fay, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Office: (585) 275-6576
Fax: (585) 473-4314

Books

Journal Articles

Showing all 140 journal articles available.

2013 Jun 4
Wakabayashi H, Fay PJ. "Modification of interdomain interfaces within the A3C1C2 subunit of factor VIII affects its stability and activity." Biochemistry.. 2013 Jun 4; 52(22):3921-9. Epub 2013 May 21.
2013 Jun 1
Wakabayashi H, Fay PJ. "Molecular orientation of factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer." The Biochemical journal. 2013 Jun 1; 452(2):293-301.
2013 Jun
Yada K, Nogami K, Wakabayashi H, Fay PJ, Shima M. "The mild phenotype in severe hemophilia A with Arg1781His mutation is associated with enhanced binding affinity of factor VIII for factor X." Thrombosis and haemostasis.. 2013 Jun; 109(6):1007-15. Epub 2013 Mar 07.
2013 May 24
Griffiths AE, Rydkin I, Fay PJ. "Factor VIIIa A2 subunit shows a high affinity interaction with factor IXa: contribution of A2 subunit residues 707-714 to the interaction with factor IXa." The Journal of biological chemistry.. 2013 May 24; 288(21):15057-64. Epub 2013 Apr 11.
2013 Apr 2
Takeyama M, Wintermute JM, Manithody C, Rezaie AR, Fay PJ. "Variable contributions of basic residues forming an APC exosite in the binding and inactivation of factor VIIIa." Biochemistry.. 2013 Apr 2; 52(13):2228-35. Epub 2013 Mar 22.
2013 Feb
Takeyama M, Wakabayashi H, Fay PJ. "Contribution of factor VIII light-chain residues 2007-2016 to an activated protein C-interactive site." Thrombosis and haemostasis.. 2013 Feb; 109(2):187-98. Epub 2012 Dec 06.
2012 May 4
Deangelis JP, Wakabayashi H, Fay PJ. "Sequences flanking Arg336 in factor VIIIa modulate factor Xa-catalyzed cleavage rates at this site and cofactor function." The Journal of biological chemistry.. 2012 May 4; 287(19):15409-17. Epub 2012 Mar 12.
2012 Apr 24
Newell-Caito JL, Griffiths AE, Fay PJ. "P3-P3' residues flanking scissile bonds in factor VIII modulate rates of substrate cleavage and procofactor activation by thrombin." Biochemistry.. 2012 Apr 24; 51(16):3451-9. Epub 2012 Apr 10.
2012 Mar
Wakabayashi H, Griffiths AE, Fay PJ. "Enhancing factor VIII and VIIIa stability by combining mutations at the A2 domain interface and A1-C2 domain interface." Journal of thrombosis and haemostasis : JTH.. 2012 Mar; 10(3):492-5.
2012 Jan 24
Takeyama M, Wakabayashi H, Fay PJ. "Factor VIII light chain contains a binding site for factor X that contributes to the catalytic efficiency of factor Xase." Biochemistry.. 2012 Jan 24; 51(3):820-8. Epub 2012 Jan 17.
2011 Nov
Deangelis JP, Varfaj F, Wakabayashi H, Fay PJ. "The role of P4-P3' residues flanking Arg336 in facilitating activated protein C-catalyzed cleavage and inactivation of factor VIIIa." Thrombosis research.. 2011 Nov; 128(5):470-6. Epub 2011 Apr 05.
2011 Aug
Griffiths AE, Wang W, Hagen FK, Fay PJ. "Use of affinity-directed liquid chromatography-mass spectrometry to map the epitopes of a factor VIII inhibitor antibody fraction." Journal of thrombosis and haemostasis : JTH.. 2011 Aug; 9(8):1534-40.
2011 Jul 22
Wakabayashi H, Griffiths AE, Fay PJ. "Increasing hydrophobicity or disulfide bridging at the factor VIII A1 and C2 domain interface enhances procofactor stability." The Journal of biological chemistry.. 2011 Jul 22; 286(29):25748-55. Epub 2011 May 31.
2011 Apr 1
Novakovic VA, Cullinan DB, Wakabayashi H, Fay PJ, Baleja JD, Gilbert GE. "Membrane-binding properties of the Factor VIII C2 domain." The Biochemical journal. 2011 Apr 1; 435(1):187-96.
2010 Aug 13
Wakabayashi H, Griffiths AE, Fay PJ. "Factor VIII lacking the C2 domain retains cofactor activity in vitro." The Journal of biological chemistry.. 2010 Aug 13; 285(33):25176-84. Epub 2010 Jun 07.
2009 Nov 20
Jagannathan I, Ichikawa HT, Kruger T, Fay PJ. "Identification of residues in the 558-loop of factor VIIIa A2 subunit that interact with factor IXa." The Journal of biological chemistry.. 2009 Nov 20; 284(47):32248-55. Epub 2009 Sep 28.
2009 Apr 24
Newell JL, Fay PJ. "Cleavage at Arg-1689 influences heavy chain cleavages during thrombin-catalyzed activation of factor VIII." The Journal of biological chemistry.. 2009 Apr 24; 284(17):11080-9. Epub 2009 Feb 24.
2009 Mar
Wakabayashi H, Griffiths AE, Fay PJ. "Combining mutations of charged residues at the A2 domain interface enhances factor VIII stability over single point mutations." Journal of thrombosis and haemostasis : JTH.. 2009 Mar; 7(3):438-44. Epub 2008 Dec 04.
2008 Oct 1
Wakabayashi H, Varfaj F, Deangelis J, Fay PJ. "Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface." Blood.. 2008 Oct 1; 112(7):2761-9. Epub 2008 Jul 23.
2008 Aug 19
Newell JL, Fay PJ. "Acidic residues C-terminal to the A2 domain facilitate thrombin-catalyzed activation of factor VIII." Biochemistry.. 2008 Aug 19; 47(33):8786-95. Epub 2008 Jul 22.
2008 Apr 25
Wakabayashi H, Fay PJ. "Identification of residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIa." The Journal of biological chemistry.. 2008 Apr 25; 283(17):11645-51. Epub 2008 Feb 25.
2007 Aug 31
Newell JL, Fay PJ. "Proteolysis at Arg740 facilitates subsequent bond cleavages during thrombin-catalyzed activation of factor VIII." The Journal of biological chemistry.. 2007 Aug 31; 282(35):25367-75. Epub 2007 Jun 26.
2007 Jul 13
Varfaj F, Wakabayashi H, Fay PJ. "Residues surrounding Arg336 and Arg562 contribute to the disparate rates of proteolysis of factor VIIIa catalyzed by activated protein C." The Journal of biological chemistry.. 2007 Jul 13; 282(28):20264-72. Epub 2007 May 22.
2007 May
Wakabayashi H, Zhou Q, Varfaj F, Fay PJ. "A3 domain residue Glu1829 contributes to A2 subunit retention in factor VIIIa." Journal of thrombosis and haemostasis : JTH.. 2007 May; 5(5):996-1001. Epub 2007 Feb 26.
2006 Nov 7
Ansong C, Miles SM, Fay PJ. "Factor VIII A1 domain residues 97-105 represent a light chain-interactive site." Biochemistry.. 2006 Nov 7; 45(44):13140-9.
2006 Jun 1
Varfaj F, Neuberg J, Jenkins PV, Wakabayashi H, Fay PJ. "Role of P1 residues Arg336 and Arg562 in the activated-Protein-C-catalysed inactivation of Factor VIIIa." The Biochemical journal. 2006 Jun 1; 396(2):355-62.
2006 Jun
Wakabayashi H, Zhou Q, Nogami K, Ansong C, Varfaj F, Miles S, Fay PJ. "pH-dependent association of factor VIII chains: enhancement of affinity at physiological pH by Cu2+." Biochimica et biophysica acta.. 2006 Jun; 1764(6):1094-101. Epub 2006 Apr 22.
2006 Apr
Ansong C, Miles SM, Fay PJ. "Epitope mapping factor VIII A2 domain by affinity-directed mass spectrometry: residues 497-510 and 584-593 comprise a discontinuous epitope for the monoclonal antibody R8B12." Journal of thrombosis and haemostasis : JTH.. 2006 Apr; 4(4):842-7.
2006 Feb
Fay PJ. "Factor VIII structure and function." International journal of hematology. 2006 Feb; 83(2):103-8.
2005 Aug 2
Wakabayashi H, Su YC, Ahmad SS, Walsh PN, Fay PJ. "A Glu113Ala mutation within a factor VIII Ca2+-binding site enhances cofactor interactions in factor Xase." Biochemistry.. 2005 Aug 2; 44(30):10298-304.
2005 Jun 21
Ansong C, Fay PJ. "Factor VIII A3 domain residues 1954-1961 represent an A1 domain-interactive site." Biochemistry.. 2005 Jun 21; 44(24):8850-7.
2005 Jun 1
Nogami K, Zhou Q, Wakabayashi H, Fay PJ. "Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P1 site." Blood.. 2005 Jun 1; 105(11):4362-8. Epub 2005 Feb 10.
2005 May 6
Nogami K, Zhou Q, Myles T, Leung LL, Wakabayashi H, Fay PJ. "Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain." The Journal of biological chemistry.. 2005 May 6; 280(18):18476-87. Epub 2005 Mar 03.
2005 Jan
Fay PJ, Jenkins PV. "Mutating factor VIII: lessons from structure to function." Blood reviews. 2005 Jan; 19(1):15-27.
2004 Sep 1
Nogami K, Wakabayashi H, Ansong C, Fay PJ. "Localization of a pH-dependent, A2 subunit-interactive surface within the factor VIIIa A1 subunit." Biochimica et biophysica acta.. 2004 Sep 1; 1701(1-2):25-35.
2004 Aug 6
Nogami K, Freas J, Manithody C, Wakabayashi H, Rezaie AR, Fay PJ. "Mechanisms of interactions of factor X and factor Xa with the acidic region in the factor VIII A1 domain." The Journal of biological chemistry.. 2004 Aug 6; 279(32):33104-13. Epub 2004 May 27.
2004 May 4
Jenkins PV, Dill JL, Zhou Q, Fay PJ. "Contribution of factor VIIIa A2 and A3-C1-C2 subunits to the affinity for factor IXa in factor Xase." Biochemistry.. 2004 May 4; 43(17):5094-101.
2004 Apr 16
Nogami K, Lapan KA, Zhou Q, Wakabayashi H, Fay PJ. "Identification of a factor Xa-interactive site within residues 337-372 of the factor VIII heavy chain." The Journal of biological chemistry.. 2004 Apr 16; 279(16):15763-71. Epub 2004 Feb 04.
2004 Mar 26
Wakabayashi H, Freas J, Zhou Q, Fay PJ. "Residues 110-126 in the A1 domain of factor VIII contain a Ca2+ binding site required for cofactor activity." The Journal of biological chemistry.. 2004 Mar 26; 279(13):12677-84. Epub 2004 Jan 13.
2004 Mar 15
Peng H, Sahni A, Fay P, Bellum S, Prudovsky I, Maciag T, Francis CW. "Identification of a binding site on human FGF-2 for fibrinogen." Blood.. 2004 Mar 15; 103(6):2114-20. Epub 2003 Nov 20.
2004 Mar
Fay PJ. "Activation of factor VIII and mechanisms of cofactor action." Blood reviews. 2004 Mar; 18(1):1-15.
2004 Mar
Jenkins PV, Dill JL, Zhou Q, Fay PJ. "Clustered basic residues within segment 484-510 of the factor VIIIa A2 subunit contribute to the catalytic efficiency for factor Xa generation." Journal of thrombosis and haemostasis : JTH.. 2004 Mar; 2(3):452-8.
2003 Jun 15
Manithody C, Fay PJ, Rezaie AR. "Exosite-dependent regulation of factor VIIIa by activated protein C." Blood.. 2003 Jun 15; 101(12):4802-7. Epub 2003 Feb 20.
2003 May 9
Nogami K, Wakabayashi H, Fay PJ. "Mechanisms of factor Xa-catalyzed cleavage of the factor VIIIa A1 subunit resulting in cofactor inactivation." The Journal of biological chemistry.. 2003 May 9; 278(19):16502-9. Epub 2003 Feb 26.
2003 Apr
Balakrishnan M, Roques BP, Fay PJ, Bambara RA. "Template dimerization promotes an acceptor invasion-induced transfer mechanism during human immunodeficiency virus type 1 minus-strand synthesis." Journal of virology.. 2003 Apr; 77(8):4710-21.
2003 Mar 7
Chen Y, Balakrishnan M, Roques BP, Fay PJ, Bambara RA. "Mechanism of minus strand strong stop transfer in HIV-1 reverse transcription." The Journal of biological chemistry.. 2003 Mar 7; 278(10):8006-17. Epub 2002 Dec 23.
2003 Jan 17
Nogami K, Wakabayashi H, Schmidt K, Fay PJ. "Altered interactions between the A1 and A2 subunits of factor VIIIa following cleavage of A1 subunit by factor Xa." The Journal of biological chemistry.. 2003 Jan 17; 278(3):1634-41. Epub 2002 Nov 07.
2003 Jan 14
Wakabayashi H, Zhen Z, Schmidt KM, Fay PJ. "Mn2+ binding to factor VIII subunits and its effect on cofactor activity." Biochemistry.. 2003 Jan 14; 42(1):145-53.
2002 Aug 9
Wisniewski M, Chen Y, Balakrishnan M, Palaniappan C, Roques BP, Fay PJ, Bambara RA. "Substrate requirements for secondary cleavage by HIV-1 reverse transcriptase RNase H." The Journal of biological chemistry.. 2002 Aug 9; 277(32):28400-10. Epub 2002 May 21.
2002 Jul 15
Jenkins PV, Freas J, Schmidt KM, Zhou Q, Fay PJ. "Mutations associated with hemophilia A in the 558-565 loop of the factor VIIIa A2 subunit alter the catalytic activity of the factor Xase complex." Blood.. 2002 Jul 15; 100(2):501-8.
2002 Jul 2
Wakabayashi H, Schmidt KM, Fay PJ. "Ca(2+) binding to both the heavy and light chains of factor VIII is required for cofactor activity." Biochemistry.. 2002 Jul 2; 41(26):8485-92.
2002 Apr 5
Koszelak Rosenblum ME, Schmidt K, Freas J, Mastri M, Fay PJ. "Cofactor activities of factor VIIIa and A2 subunit following cleavage of A1 subunit at Arg336." The Journal of biological chemistry.. 2002 Apr 5; 277(14):11664-9. Epub 2002 Jan 17.
2002
Roda RH, Balakrishnan M, Kim JK, Roques BP, Fay PJ, Bambara RA. "Strand transfer occurs in retroviruses by a pause-initiated two-step mechanism." The Journal of biological chemistry.. 2002 277(49):46900-11. Epub 2002 Oct 04.
2001 Sep 28
Balakrishnan M, Fay PJ, Bambara RA. "The kissing hairpin sequence promotes recombination within the HIV-I 5' leader region." The Journal of biological chemistry.. 2001 Sep 28; 276(39):36482-92. Epub 2001 Jun 29.
2001 Aug 28
Wakabayashi H, Koszelak ME, Mastri M, Fay PJ. "Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinity." Biochemistry.. 2001 Aug 28; 40(34):10293-300.
2001 Jul 9
Fay PJ, Mastri M, Koszelak ME. "Factor VIIIa cofactor activity shows enhanced ionic strength sensitivity in the absence of phospholipid." Biochimica et biophysica acta.. 2001 Jul 9; 1548(1):159-68.
2001 May 11
Bajaj SP, Schmidt AE, Mathur A, Padmanabhan K, Zhong D, Mastri M, Fay PJ. "Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIa." The Journal of biological chemistry.. 2001 May 11; 276(19):16302-9. Epub 2001 Feb 14.
2001 Apr 13
Fay PJ, Mastri M, Koszelak ME, Wakabayashi H. "Cleavage of factor VIII heavy chain is required for the functional interaction of a2 subunit with factor IXA." The Journal of biological chemistry.. 2001 Apr 13; 276(15):12434-9. Epub 2001 Jan 22.
2000 Oct 24
Wisniewski M, Balakrishnan M, Palaniappan C, Fay PJ, Bambara RA. "Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H." Proceedings of the National Academy of Sciences of the United States of America.. 2000 Oct 24; 97(22):11978-83.
2000 Sep 1
Koszelak ME, Huggins CF, Fay PJ. "Sites in the A2 subunit involved in the interfactor VIIIa interaction." The Journal of biological chemistry.. 2000 Sep 1; 275(35):27137-44.
2000 Mar 1
O'Brien LM, Mastri M, Fay PJ. "Regulation of factor VIIIa by human activated protein C and protein S: inactivation of cofactor in the intrinsic factor Xase." Blood.. 2000 Mar 1; 95(5):1714-20.
2000
Wisniewski M, Balakrishnan M, Palaniappan C, Fay PJ, Bambara RA. "The sequential mechanism of HIV reverse transcriptase RNase H." The Journal of biological chemistry.. 2000 275(48):37664-71.
1999 Oct 15
Fay PJ, Scandella D. "Human inhibitor antibodies specific for the factor VIII A2 domain disrupt the interaction between the subunit and factor IXa." The Journal of biological chemistry.. 1999 Oct 15; 274(42):29826-30.
1999 Aug
Fay PJ. "Regulation of factor VIIIa in the intrinsic factor Xase." Thrombosis and haemostasis.. 1999 Aug; 82(2):193-200.
1999 Jul
Gerondelis P, Archer RH, Palaniappan C, Reichman RC, Fay PJ, Bambara RA, Demeter LM. "The P236L delavirdine-resistant human immunodeficiency virus type 1 mutant is replication defective and demonstrates alterations in both RNA 5'-end- and DNA 3'-end-directed RNase H activities." Journal of virology.. 1999 Jul; 73(7):5803-13.
1999 May 28
Fay PJ, Koshibu K, Mastri M. "The A1 and A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity." The Journal of biological chemistry.. 1999 May 28; 274(22):15401-6.
1998 Sep
Lapan KA, Fay PJ. "Interaction of the A1 subunit of factor VIIIa and the serine protease domain of factor X identified by zero-length cross-linking." Thrombosis and haemostasis.. 1998 Sep; 80(3):418-22.
1998 Jul 24
Fay PJ, Koshibu K. "The A2 subunit of factor VIIIa modulates the active site of factor IXa." The Journal of biological chemistry.. 1998 Jul 24; 273(30):19049-54.
1998 May 12
Sudhakar K, Fay PJ. "Effects of copper on the structure and function of factor VIII subunits: evidence for an auxiliary role for copper ions in cofactor activity." Biochemistry.. 1998 May 12; 37(19):6874-82.
1998 Mar 15
Siddiqi F, Odrljin TM, Fay PJ, Cox C, Francis CW. "Binding of tissue-plasminogen activator to fibrin: effect of ultrasound." Blood.. 1998 Mar 15; 91(6):2019-25.
1998 Feb 13
Palaniappan C, Kim JK, Wisniewski M, Fay PJ, Bambara RA. "Control of initiation of viral plus strand DNA synthesis by HIV reverse transcriptase." The Journal of biological chemistry.. 1998 Feb 13; 273(7):3808-16.
1997 Nov 15
O'Brien LM, Huggins CF, Fay PJ. "Interacting regions in the A1 and A2 subunits of factor VIIIa identified by zero-length cross-linking." Blood.. 1997 Nov 15; 90(10):3943-50.
1997 Jul 4
Kim JK, Palaniappan C, Wu W, Fay PJ, Bambara RA. "Evidence for a unique mechanism of strand transfer from the transactivation response region of HIV-1." The Journal of biological chemistry.. 1997 Jul 4; 272(27):16769-77.
1997 Apr 25
Palaniappan C, Wisniewski M, Jacques PS, Le Grice SF, Fay PJ, Bambara RA. "Mutations within the primer grip region of HIV-1 reverse transcriptase result in loss of RNase H function." The Journal of biological chemistry.. 1997 Apr 25; 272(17):11157-64.
1997 Jan 24
Lapan KA, Fay PJ. "Localization of a factor X interactive site in the A1 subunit of factor VIIIa." The Journal of biological chemistry.. 1997 Jan 24; 272(4):2082-8.
1996 Nov 22
Fuentes GM, Palaniappan C, Fay PJ, Bambara RA. "Strand displacement synthesis in the central polypurine tract region of HIV-1 promotes DNA to DNA strand transfer recombination." The Journal of biological chemistry.. 1996 Nov 22; 271(47):29605-11.
1996 Sep 20
Sudhakar K, Fay PJ. "Exposed hydrophobic sites in factor VIII and isolated subunits." The Journal of biological chemistry.. 1996 Sep 20; 271(38):23015-21.
1996 Sep 13
Palaniappan C, Wisniewski M, Wu W, Fay PJ, Bambara RA. "Misincorporation by HIV-1 reverse transcriptase promotes recombination via strand transfer synthesis." The Journal of biological chemistry.. 1996 Sep 13; 271(37):22331-8.
1996 May 1
Wu W, Palaniappan C, Bambara RA, Fay PJ. "Differences in mutagenesis during minus strand, plus strand and strand transfer (recombination) synthesis of the HIV-1 gene in vitro." Nucleic acids research.. 1996 May 1; 24(9):1710-8.
1996 May 1
Fuentes GM, Fay PJ, Bambara RA. "Relationship between plus strand DNA synthesis removal of downstream segments of RNA by human immunodeficiency virus, murine leukemia virus and avian myeloblastoma virus reverse transcriptases." Nucleic acids research.. 1996 May 1; 24(9):1719-26.
1996 Mar 15
Fay PJ, Beattie TL, Regan LM, O'Brien LM, Kaufman RJ. "Model for the factor VIIIa-dependent decay of the intrinsic factor Xase. Role of subunit dissociation and factor IXa-catalyzed proteolysis." The Journal of biological chemistry.. 1996 Mar 15; 271(11):6027-32.
1996 Feb 23
Regan LM, O'Brien LM, Beattie TL, Sudhakar K, Walker FJ, Fay PJ. "Activated protein C-catalyzed proteolysis of factor VIIIa alters its interactions within factor Xase." The Journal of biological chemistry.. 1996 Feb 23; 271(8):3982-7.
1996 Jan 26
Fuentes GM, Rodríguez-Rodríguez L, Palaniappan C, Fay PJ, Bambara RA. "Strand displacement synthesis of the long terminal repeats by HIV reverse transcriptase." The Journal of biological chemistry.. 1996 Jan 26; 271(4):1966-71.
1996 Jan 26
Palaniappan C, Fuentes GM, Rodríguez-Rodríguez L, Fay PJ, Bambara RA. "Helix structure and ends of RNA/DNA hybrids direct the cleavage specificity of HIV-1 reverse transcriptase RNase H." The Journal of biological chemistry.. 1996 Jan 26; 271(4):2063-70.
1995 Nov 24
Fuentes GM, Rodríguez-Rodríguez L, Fay PJ, Bambara RA. "Use of an oligoribonucleotide containing the polypurine tract sequence as a primer by HIV reverse transcriptase." The Journal of biological chemistry.. 1995 Nov 24; 270(47):28169-76.
1995 Nov 10
O'Brien LM, Medved LV, Fay PJ. "Localization of factor IXa and factor VIIIa interactive sites." The Journal of biological chemistry.. 1995 Nov 10; 270(45):27087-92.
1995 Jun 23
Rodríguez-Rodríguez L, Tsuchihashi Z, Fuentes GM, Bambara RA, Fay PJ. "Influence of human immunodeficiency virus nucleocapsid protein on synthesis and strand transfer by the reverse transcriptase in vitro." The Journal of biological chemistry.. 1995 Jun 23; 270(25):15005-11.
1995 Apr 14
Regan LM, Fay PJ. "Cleavage of factor VIII light chain is required for maximal generation of factor VIIIa activity." The Journal of biological chemistry.. 1995 Apr 14; 270(15):8546-52.
1995 Mar 3
Palaniappan C, Fay PJ, Bambara RA. "Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase." The Journal of biological chemistry.. 1995 Mar 3; 270(9):4861-9.
1995 Jan 6
Wu W, Blumberg BM, Fay PJ, Bambara RA. "Strand transfer mediated by human immunodeficiency virus reverse transcriptase in vitro is promoted by pausing and results in misincorporation." The Journal of biological chemistry.. 1995 Jan 6; 270(1):325-32.
1995
Bambara RA, Fay PJ, Mallaber LM. "Methods of analyzing processivity." Methods in enzymology. 1995 262:270-80.
1994 Oct 18
DeStefano JJ, Wu W, Seehra J, McCoy J, Laston D, Albone E, Fay PJ, Bambara RA. "Characterization of an RNase H deficient mutant of human immunodeficiency virus-1 reverse transcriptase having an aspartate to asparagine change at position 498." Biochimica et biophysica acta.. 1994 Oct 18; 1219(2):380-8.
1994 Sep 11
DeStefano JJ, Mallaber LM, Fay PJ, Bambara RA. "Quantitative analysis of RNA cleavage during RNA-directed DNA synthesis by human immunodeficiency and avian myeloblastosis virus reverse transcriptases." Nucleic acids research.. 1994 Sep 11; 22(18):3793-800.
1994 Aug 12
Fay PJ, Beattie T, Huggins CF, Regan LM. "Factor VIIIa A2 subunit residues 558-565 represent a factor IXa interactive site." The Journal of biological chemistry.. 1994 Aug 12; 269(32):20522-7.
1994 Apr 1
Regan LM, Lamphear BJ, Huggins CF, Walker FJ, Fay PJ. "Factor IXa protects factor VIIIa from activated protein C. Factor IXa inhibits activated protein C-catalyzed cleavage of factor VIIIa at Arg562." The Journal of biological chemistry.. 1994 Apr 1; 269(13):9445-52.
1994 Jan 7
DeStefano JJ, Bambara RA, Fay PJ. "The mechanism of human immunodeficiency virus reverse transcriptase-catalyzed strand transfer from internal regions of heteropolymeric RNA templates." The Journal of biological chemistry.. 1994 Jan 7; 269(1):161-8.
1993 Nov 1
Wolf RJ, Lee MW, Davis RC, Fay PJ, Ray JR. "Pressure-composition isotherms for palladium hydride." Physical review. B, Condensed matter. 1993 Nov 1; 48(17):12415-12418.
1993 Oct 19
Buiser RG, Bambara RA, Fay PJ. "Pausing by retroviral DNA polymerases promotes strand transfer from internal regions of RNA donor templates to homopolymeric acceptor templates." Biochimica et biophysica acta.. 1993 Oct 19; 1216(1):20-30.
1993 Oct 15
Lawrence SO, Wright TW, Francis CW, Fay PJ, Haidaris PJ. "Purification and functional characterization of homodimeric gamma B-gamma B fibrinogen from rat plasma." Blood.. 1993 Oct 15; 82(8):2406-13.
1993 Sep 11
DeStefano JJ, Mallaber LM, Fay PJ, Bambara RA. "Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase." Nucleic acids research.. 1993 Sep 11; 21(18):4330-8.
1993 Aug 25
Fay PJ, Haidaris PJ, Huggins CF. "Role of the COOH-terminal acidic region of A1 subunit in A2 subunit retention in human factor VIIIa." The Journal of biological chemistry.. 1993 Aug 25; 268(24):17861-6.
1993 Jul 13
DeStefano JJ, Bambara RA, Fay PJ. "Parameters that influence the binding of human immunodeficiency virus reverse transcriptase to nucleic acid structures." Biochemistry.. 1993 Jul 13; 32(27):6908-15.
1993 Jul 1
Fay PJ. "Factor VIII structure and function." Thrombosis and haemostasis.. 1993 Jul 1; 70(1):63-7.
1993
Lollar P, Fay PJ, Fass DN. "Factor VIII and factor VIIIa." Methods in enzymology. 1993 222:128-43.
1992 Nov 25
Lollar P, Parker ET, Fay PJ. "Coagulant properties of hybrid human/porcine factor VIII molecules." The Journal of biological chemistry.. 1992 Nov 25; 267(33):23652-7.
1992 Nov
DeStefano JJ, Mallaber LM, Rodriguez-Rodriguez L, Fay PJ, Bambara RA. "Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase." Journal of virology.. 1992 Nov; 66(11):6370-8.
1992 Oct 15
Fay PJ, Ray JR. "Monte Carlo simulations in the isoenthalpic-isotension-isobaric ensemble." Physical review. A. 1992 Oct 15; 46(8):4645-4649.
1992 Jul 15
DeStefano JJ, Buiser RG, Mallaber LM, Fay PJ, Bambara RA. "Parameters that influence processive synthesis and site-specific termination by human immunodeficiency virus reverse transcriptase on RNA and DNA templates." Biochimica et biophysica acta.. 1992 Jul 15; 1131(3):270-80.
1992 Jul 5
Fay PJ, Smudzin TM. "Characterization of the interaction between the A2 subunit and A1/A3-C1-C2 dimer in human factor VIIIa." The Journal of biological chemistry.. 1992 Jul 5; 267(19):13246-50.
1992 May
Walker FJ, Fay PJ. "Regulation of blood coagulation by the protein C system." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 1992 May; 6(8):2561-7.
1992 Feb 25
Lamphear BJ, Fay PJ. "Factor IXa enhances reconstitution of factor VIIIa from isolated A2 subunit and A1/A3-C1-C2 dimer." The Journal of biological chemistry.. 1992 Feb 25; 267(6):3725-30.
1992
Lamphear BJ, Fay PJ. "Proteolytic interactions of factor IXa with human factor VIII and factor VIIIa." Blood.. 1992 80(12):3120-6.
1991 Oct 25
Fay PJ, Smudzin TM, Walker FJ. "Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity." The Journal of biological chemistry.. 1991 Oct 25; 266(30):20139-45.
1991 Jul 15
Buiser RG, DeStefano JJ, Mallaber LM, Fay PJ, Bambara RA. "Requirements for the catalysis of strand transfer synthesis by retroviral DNA polymerases." The Journal of biological chemistry.. 1991 Jul 15; 266(20):13103-9.
1991 May 15
Fay PJ, Haidaris PJ, Smudzin TM. "Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit." The Journal of biological chemistry.. 1991 May 15; 266(14):8957-62.
1991 Apr 25
DeStefano JJ, Buiser RG, Mallaber LM, Myers TW, Bambara RA, Fay PJ. "Polymerization and RNase H activities of the reverse transcriptases from avian myeloblastosis, human immunodeficiency, and Moloney murine leukemia viruses are functionally uncoupled." The Journal of biological chemistry.. 1991 Apr 25; 266(12):7423-31.
1991 Feb 5
Fay PJ, Coumans JV, Walker FJ. "von Willebrand factor mediates protection of factor VIII from activated protein C-catalyzed inactivation." The Journal of biological chemistry.. 1991 Feb 5; 266(4):2172-7.
1991
DeStefano JJ, Buiser RG, Mallaber LM, Bambara RA, Fay PJ. "Human immunodeficiency virus reverse transcriptase displays a partially processive 3' to 5' endonuclease activity." The Journal of biological chemistry.. 1991 266(36):24295-301.
1990 Oct
Fowler WE, Fay PJ, Arvan DS, Marder VJ. "Electron microscopy of human factor V and factor VIII: correlation of morphology with domain structure and localization of factor V activation fragments." Proceedings of the National Academy of Sciences of the United States of America.. 1990 Oct; 87(19):7648-52.
1990 Apr 15
Fay PJ, Smudzin TM. "Topography of the human factor VIII-von Willebrand factor complex." The Journal of biological chemistry.. 1990 Apr 15; 265(11):6197-202.
1990 Feb 5
Walker FJ, Fay PJ. "Characterization of an interaction between protein C and ceruloplasmin." The Journal of biological chemistry.. 1990 Feb 5; 265(4):1834-6.
1990 Jan 25
Walker FJ, Scandella D, Fay PJ. "Identification of the binding site for activated protein C on the light chain of factors V and VIII." The Journal of biological chemistry.. 1990 Jan 25; 265(3):1484-9.
1989 Aug 25
Fay PJ, Smudzin TM. "Intersubunit fluorescence energy transfer in human factor VIII." The Journal of biological chemistry.. 1989 Aug 25; 264(24):14005-10.
1989 Feb 2
Fay PJ, Walker FJ. "Inactivation of human factor VIII by activated protein C: evidence that the factor VIII light chain contains the activated protein C binding site." Biochimica et biophysica acta.. 1989 Feb 2; 994(2):142-8.
1988 May 1
Fay PJ. "Reconstitution of human factor VIII from isolated subunits." Archives of biochemistry and biophysics.. 1988 May 1; 262(2):525-31.
1988 Jan 29
Fay PJ. "Subunit structure of thrombin-activated human factor VIIIa." Biochimica et biophysica acta.. 1988 Jan 29; 952(2):181-90.
1987 Apr
Wagner DD, Fay PJ, Sporn LA, Sinha S, Lawrence SO, Marder VJ. "Divergent fates of von Willebrand factor and its propolypeptide (von Willebrand antigen II) after secretion from endothelial cells." Proceedings of the National Academy of Sciences of the United States of America.. 1987 Apr; 84(7):1955-9.
1987 Jan
Walker FJ, Chavin SI, Fay PJ. "Inactivation of factor VIII by activated protein C and protein S." Archives of biochemistry and biophysics.. 1987 Jan; 252(1):322-8.
1987 Jan
Wagner DD, Lawrence SO, Ohlsson-Wilhelm BM, Fay PJ, Marder VJ. "Topology and order of formation of interchain disulfide bonds in von Willebrand factor." Blood.. 1987 Jan; 69(1):27-32.
1986 Jun 23
Fay PJ, Anderson MT, Chavin SI, Marder VJ. "The size of human factor VIII heterodimers and the effects produced by thrombin." Biochimica et biophysica acta.. 1986 Jun 23; 871(3):268-78.
1986 May 23
Fay PJ, Kawai Y, Wagner DD, Ginsburg D, Bonthron D, Ohlsson-Wilhelm BM, Chavin SI, Abraham GN, Handin RI, Orkin SH. "Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II." Science (New York, N.Y.). 1986 May 23; 232(4753):995-8.
1986 Feb 1
Fay PJ, Cavallaro C, Marder VJ, Pancham N, Fournel MA, Schroeder DD. "Comparison of the in vivo survival of human factor VIII with and without von Willebrand factor in the hemophilic dog." Thrombosis research.. 1986 Feb 1; 41(3):425-9.
1984 Jul 30
Fay PJ, Chavin SI, Malone JE, Schroeder D, Young FE, Marder VJ. "The effect of carbohydrate depletion on procoagulant activity and in vivo survival of highly purified human factor VIII." Biochimica et biophysica acta.. 1984 Jul 30; 800(2):152-8.
1983 Oct 25
LaDuca RJ, Fay PJ, Chuang C, McHenry CS, Bambara RA. "Site-specific pausing of deoxyribonucleic acid synthesis catalyzed by four forms of Escherichia coli DNA polymerase III." Biochemistry.. 1983 Oct 25; 22(22):5177-88.
1982 May 25
Fay PJ, Johanson KO, McHenry CS, Bambara RA. "Size classes of products synthesized processively by two subassemblies of Escherichia coli DNA polymerase III holoenzyme." The Journal of biological chemistry.. 1982 May 25; 257(10):5692-9.
1982
Fay PJ, Chavin SI, Schroeder D, Young FE, Marder VJ. "Purification and characterization of a highly purified human factor VIII consisting of a single type of polypeptide chain." Proceedings of the National Academy of Sciences of the United States of America.. 1982 79(23):7200-204.
1981 Aug 10
Villani G, Fay PJ, Bambara RA, Lehman IR. "Elongation of RNA-primed DNA templates by DNA polymerase alpha from Drosophila melanogaster embryos." The Journal of biological chemistry.. 1981 Aug 10; 256(15):8202-7.
1981 Jan 25
Fay PJ, Johanson KO, McHenry CS, Bambara RA. "Size classes of products synthesized processively by DNA polymerase III and DNA polymerase III holoenzyme of Escherichia coli." The Journal of biological chemistry.. 1981 Jan 25; 256(2):976-83.
1980 May 13
Matson SW, Fay PJ, Bambara RA. "Mechanism of inhibition of the avian myeloblastosis virus deoxyribonucleic acid polymerase by adriamycin." Biochemistry.. 1980 May 13; 19(10):2089-96.
1971 Feb
Klubes P, Fay PJ, Cerna I. "Effect of chlorpromazine on cell wall biosynthesis and incorporation of orotic acid into nucleic acids in Bacillus megaterium." Biochemical pharmacology. 1971 Feb; 20(2):265-77.