Robert T. Dirksen, Ph.D.

Robert T. Dirksen, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Office: (585) 275-4824
Lab: (585) 273-2170
Fax: (585) 273-2652

Journal Articles

Showing all 94 journal articles available.

2013 Feb
Kraeva N, Zvaritch E, Rossi AE, Goonasekera SA, Zaid H, Frodis W, Kraev A, Dirksen RT, Maclennan DH, Riazi S. "Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease." Neuromuscular disorders : NMD. 2013 Feb; 23(2):120-32. Epub 2012 Nov 24.
2012 Jul 18
Yarotskyy V, Dirksen RT. "Temperature and RyR1 regulate the activation rate of store-operated Ca²+ entry current in myotubes." Biophysical journal. 2012 Jul 18; 103(2):202-11. Epub 2012 Jul 17.
2012 Jun
Sheu SS, Dirksen RT, Pugh EN. "Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondria take center stage." The Journal of general physiology. 2012 Jun; 139(6):391-3.
2012 Jun
Wei L, Dirksen RT. "Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial superoxide flashes: from discovery to new controversies." The Journal of general physiology. 2012 Jun; 139(6):425-34.
2012 Mar 15
Tang ZZ, Yarotskyy V, Wei L, Sobczak K, Nakamori M, Eichinger K, Moxley RT, Dirksen RT, Thornton CA. "Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel." Human molecular genetics. 2012 Mar 15; 21(6):1312-24. Epub 2011 Dec 02.
2012 Mar
Liu X, Yu L, Wang Q, Pelletier J, Fausther M, Sévigny J, Malmström HS, Dirksen RT, Ren YF. "Expression of ecto-ATPase NTPDase2 in human dental pulp." Journal of dental research. 2012 Mar; 91(3):261-7. Epub 2011 Dec 14.
2012 Feb
Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL. "AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation." Nature medicine. 2012 Feb; 18(2):244-51. Epub 2012 Jan 08.
2012 Jan 6
Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG. "Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1." Circulation research. 2012 Jan 6; 110(1):59-70. Epub 2011 Nov 10.
2012
Lanner, J.T.; Georgiou, D.K.; Dagnino-Acosta, A.; Ainbinder, A.; Cheng, Q.; Joshi, A.D.; Chen, Z.; Yarotskyy, V.; Oakes, J.M.; Lee, C.S.; Monroe, T.O.; Santillan, A.; Dong, K.; Goodyear, L.; Ismailov II; Rodney, G.G.; Dirksen, R.T.; Hamilton, S.L. "AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation." Nat. Med. 2012; 18: 244-51.
2012
Loy RE, Lueck JD, Mostajo-Radji MA, Carrell EM, Dirksen RT. "Allele-specific gene silencing in two mouse models of autosomal dominant skeletal myopathy." PloS one. 2012 7(11):e49757. Epub 2012 Nov 12.
2011 Nov 15
Huang Z, Zhang W, Fang H, Zheng M, Wang X, Xu J, Cheng H, Gong G, Wang W, Dirksen RT, Sheu SS. "Response to "A critical evaluation of cpYFP as a probe for superoxide"." Free radical biology & medicine. 2011 Nov 15; 51(10):1937-40. Epub 2011 Aug 30.
2011 Nov 15
Lefebvre R, Legrand C, González-Rodríguez E, Groom L, Dirksen RT, Jacquemond V. "Defects in Ca2+ release associated with local expression of pathological ryanodine receptors in mouse muscle fibres." The Journal of physiology. 2011 Nov 15; 589(Pt 22):5361-82. Epub 2011 Oct 03.
2011 Nov
Rossi AE, Boncompagni S, Wei L, Protasi F, Dirksen RT. "Differential impact of mitochondrial positioning on mitochondrial Ca(2+) uptake and Ca(2+) spark suppression in skeletal muscle." American journal of physiology. Cell physiology. 2011 Nov; 301(5):C1128-39. Epub 2011 Aug 17.
2011 Nov
Groom L, Muldoon SM, Tang ZZ, Brandom BW, Bayarsaikhan M, Bina S, Lee HS, Qiu X, Sambuughin N, Dirksen RT. "Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families." Anesthesiology. 2011 Nov; 115(5):938-45.
2011 Sep
Wei L, Salahura G, Boncompagni S, Kasischke KA, Protasi F, Sheu SS, Dirksen RT. "Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2011 Sep; 25(9):3068-78. Epub 2011 Jun 06.
2011 Jun 17
Ryu SY, Beutner G, Kinnally KW, Dirksen RT, Sheu SS. "Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts." The Journal of biological chemistry. 2011 Jun 17; 286(24):21324-9. Epub 2011 Apr 27.
2011 Jan
Loy RE, Orynbayev M, Xu L, Andronache Z, Apostol S, Zvaritch E, MacLennan DH, Meissner G, Melzer W, Dirksen RT. "Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum." The Journal of general physiology. 2011 Jan; 137(1):43-57. Epub 2010 Dec 13.
2011
Tae H, Wei L, Willemse H, Mirza S, Gallant EM, Board PG, Dirksen RT, Casarotto MG, Dulhunty A. "The elusive role of the SPRY2 domain in RyR1." Channels. 2011 5(2):148-60. Epub 2011 Mar 01.
2011
Sheu SS, Dirksen RT, Pugh EN. "The 65th Symposium of the Society for General Physiologists: energizing research in mitochondrial physiology and medicine." The Journal of general physiology. 2011 138(6):563-7.
2010 Jul
Dirksen RT, Pugh EN. "Emerging questions about the macromolecular machines of muscle." The Journal of general physiology. 2010 Jul; 136(1):3-5.
2010 May 17
Ryu SY, Beutner G, Dirksen RT, Kinnally KW, Sheu SS. "Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels." FEBS letters. 2010 May 17; 584(10):1948-55. Epub 2010 Jan 21.
2010 Mar
Zhou H, Lillis S, Loy RE, Ghassemi F, Rose MR, Norwood F, Mills K, Al-Sarraj S, Lane RJ, Feng L, Matthews E, Sewry CA, Abbs S, Buk S, Hanna M, Treves S, Dirksen RT, Meissner G, Muntoni F, Jungbluth H. "Multi-minicore disease and atypical periodic paralysis associated with novel mutations in the skeletal muscle ryanodine receptor (RYR1) gene." Neuromuscular disorders : NMD. 2010 Mar; 20(3):166-73. Epub 2010 Jan 18.
2010
Boncompagni S, Loy RE, Dirksen RT, Franzini-Armstrong C. "The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging." Aging cell. 2010 9(6):958-70. Epub 2010 Oct 21.
2010
Lueck JD, Rossi AE, Thornton CA, Campbell KP, Dirksen RT. "Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle." The Journal of general physiology. 2010 136(6):597-613. Epub 2010 Nov 15.
2009
Kimura, K; Lueck, JD; Harvey, PJ; Pace, SM; Ikemoto, N; Casarotto, MG; *Dirksen, RT; and *Dulhunty, AF. "Alternative splicing of RyR1 influences the efficacy of skeletal EC coupling." Cell Calcium. 2009; In Press.
2009
Boncompagni, S; Rossi, AE; Micaroni, M; Beznoussenko, GV; Polishchuk, RS; *Dirksen, RT; and *Protasi, F. "Muscle mitochondria are structurally linked to Ca2+ release units by developmentally regulated tethering structures." Mol. Biol. Cell. 2009; : 1058-1067.
2009
Oestreich, EA; Malik, S; Goonasekera, SA; Blaxall, BC; Kelley, GG; Dirksen, RT; and Smrcka, AV. "Epac and PLC? regulate Ca2+ release in the heart by activation of PKC? and CaMKII." J. Biol. Chem. 2009; 284: 1514-1522.
2009
Lyfenko, AD; Schuhmeier, RP; Avila, G; Melzer, W; and Dirksen, RT. "A recessive CCD mutation in RyR1 (V4849I) increases voltage-gated Ca2+ release and SR Ca2+ release flux following homozygous expression in dyspedic myotubes." 2009; In preparation.
2009
Andronache, Z.; Hamilton, SL; Dirksen, RT; and Melzer, W. "A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ leak in muscle fibers of Y522S RyR1 knock-in mice." Proc. Natl. Acad. Sci. 2009; In Press.
2009
Marco, M; Quarta, M; Lyfenko, AD; Paolini, C; Canato, M; Riggiani, C; Dirksen, RT; and Protasi, F. "Anesthetic- and heat-induced sudden death in calsequestrin-1 knockout mice." FASEB J. 2009; In Press.
2009
Fallon, JL; Baker, MR; Loy, RE; Xiong, L; Yang, G; Dirksen, RT; Hamilton, SL; Quiocho, FA. "Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+ calmodulin." Proc. Natl. Acad. Sci. 2009; In Press.
2009
Wheeler, TM; Sobczak, K; Lueck, JD; Osborne, RJ; Lix, X; Dirksen, RT; Thornton, CA. "Reversal of RNA-dominant disease by antisense displacement of protein sequestered on repetitive RNA." 2009; In Revision.
2009
Lyfenko, AD; Schuhmeier, RP; Avila, G; Melzer, W; and Dirksen, RT. "A recessive CCD mutation in RyR1 (V4849I) increases voltage-gated Ca2+ release and SR Ca2+ release flux following homozygous expression in dyspedic myotubes." 2009; In Preparation.
2009
Boncompagni, S.; Rossi, A.E.; Micaroni, M.; Hamilton, S.L.; Dirksen, R.T.; Franzini-Armstrong, C.; Protasi, F. "Characterization and temporal development of cores in a mouse model of malignant hyperthermia." Proc Natl Acad Sci USA. 2009; 106(51): 21996-2001.
2008
Durham, WJ; Aracena-Parks, P; Long, C*; Rossi, AE; Goonasekera, SA; Boncompagni, S; Gilman, CP; Galvan, DL; Baker, M; Shirokova, N; Protasi, P; Dirksen, RT; and Hamilton, S. "RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knock-in mice." Cell. 2008; 133: 1-13.
2008
Wang, W; Fang, W; Groom, L; Cheng, A; Zhang, W; Liu, J; Wang, X; Li, K; Han, P; Zhang, M; Yin, J; Wang, W; Mattson, MP; Kao, JPY; Lakatta, EG; Sheu, S-S; Ouyang, K; Chen, J; Dirksen, RT; and Cheng, H. "Superoxide flashes in single mitochondria." Cell. 2008; 134: 279-290.
2008
Lyfenko, AD; and Dirksen, RT. "Differential dependence of store-operated and excitation-coupled Ca2+ entry in skeletal muscle on Stim1 and Orai1." J. Physiol. 2008; .
2008
Marco, M; Quarta, M; Lyfenko, AD; Paolini, C; Canato, M; Dirksen, RT; Reggiani, C; and Protasi, F. "Heat- and anesthetic-induced malignant hyperthermia in calsequestrin-1 knockout mice." 2008; Submitted.
2008
Wheeler, TM; Sobczak, K; Lueck, JD; Osborne, RJ; Lin, X; Dirksen, RT; and Thornton, CA. "Reversal of RNA-dominant disease by antisense displacement of protein sequestered on repetitive RNA." 2008; Submitted.
2007
Kimura, T; Pace, SM; Wei, L; Beard, NA; Dirksen, RT; and Dulhunty, AF. "A Variable spliced region of the type 1 ryanodine receptor may participate in an interdomain interaction." Biochem. J. 2007; 401: 317-324.
2007
Oestreich, EA; Wang, H*; Malik, S; Kaproth-Joslin, KA; Blaxall, BC; Kelley, GG; Dirksen, RT; and Smrcka, AV. "Epac-mediated Activation of Phospholipase C? Plays a Critical Role in ?-adrenergic Receptor Dependent Enhancement of Ca2+ Mobilization in Cardiac Myocytes." J. Biol. Chem. 2007; 282: 5488-5495.
2007
Lyfenko, AD; Ducreux, S; Wang, Y; Xu, L; Zorzato, F; Ferreiro, A; Meissner, G; Treves, S; and Dirksen, RT. "Two central core disease deletions in the C-terminal region of RyR1 alter muscle EC coupling by distinct mechanisms." Hum. Mutat. 2007; 28: 61-68.
2007
Lueck, JD; Mankodi, A; Swanson, MS; Thornton, CA; and Dirksen, RT. "Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy." J. Gen. Physiol. 2007; 129: 79-94.
2007
Rossi, D; De Smet, P; Lyfenko, A; Galli, L; Lorenzini, S; Franci, D; Petrioli, F; Orrico, A; Tegazzin, V; Dirksen, RT; and Sorrentino, V. "A Truncation in the RYR1 Gene Associated with Central Core Lesions in Skeletal Muscle Fibers." J. Med. Genet. 2007; 44: e67.
2007
Lueck, JD; Lungu, C; Mankodi, A; Osborne, RJ; Welle, SL; Dirksen, RT; and Thornton, CA. "Chloride channelopathy in myotonic dystrophy resulting from loss of post-transcriptional regulation for CLCN1." Am. J. Physiol. 2007; 292: C1291-C1297.
2007
Goonasekera, S; Beard, N; Groom, L; Kimura, T; Lyfenko, AF; Rosenfeld, A; Marty, I; Dulhunty, A; and Dirksen, RT. "Triadin binding to the C-terminal luminal loop of the ryanodine receptor is important for skeletal muscle excitation-contraction coupling." J. Gen. Physiol. 2007; 130: 365-378.
2007
Wheeler, TM; Lueck, JD; Swanson, MS; Dirksen, RT; and Thornton, CA. "Correction of ClC-1 splicing eliminates the chloride channelopathy and myotonia in myotonic dystrophy." J. Clin. Invest. 2007; 117: 3952-3957.
2007
Zvaritch, E; Depreux, F; Kraeva, N; Loy, RE; Goonasekera, SA; Boncompagi, S; Kraev, A; Gramolini, AO; Dirksen, RT; Franzini-Armstrong, C; Seidman, CE; Seidman, JG; and MacLennan, DH. "A Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line." Proc. Natl. Acad. Sci. 2007; 104: 18537-18542.
2006 Jun
Rossi AE, Dirksen RT. "Sarcoplasmic reticulum: the dynamic calcium governor of muscle." Muscle & nerve. 2006 Jun; 33(6):715-31.
2006 Feb
Chelu MG, Goonasekera SA, Durham WJ, Tang W, Lueck JD, Riehl J, Pessah IN, Zhang P, Bhattacharjee MB, Dirksen RT, Hamilton SL. "Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Feb; 20(2):329-30. Epub 2005 Nov 11.
2006
Rosenberg, H.; Dirksen, R.T.;. "Malignant Hyperthermia Susceptibility". GeneReviews. 2006; .
2006
Kannankeril,P.J.; Mitchell,B.M.; Goonasekera,S.A.; Chelu,M.G.; Zhang,W.; Sood,S.; Kearney,D.L.; Danila,C.I.; De Biasi,M.; Wehrens,X.H.; Pautler,R.G.; Roden,D.M.; Taffet,G.E.; Dirksen,R.T.; Anderson,M.E.; Hamilton,S.L.;. "Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy". Proceedings National Academy Sciences United States of America. 2006; 103: 12179-12184.
2006
Kannankeril, PJ; Mitchell, BM; Goonasekera, SA; Chelu, MG; Zhang, W; Sood, S; Kearney, DL; Danila, C; DeBiasi, M; Wehrens, X; Pautler, RG; Roden, DM; Taffet, GE; Dirksen, RT; Anderson, ME; and Hamilton, SL. "Mice with the R176Q Cardiac Ryanodine Receptor Mutation Exhibit Catecholamine-Induced Ventricular Tachycardia and Mild Cardiomyopathy." Proc. Natl. Acad. Sci. 2006; 103: 12179-12184.
2006
Aracena-Parks, P; Goonasekera, SA; Gilman, C; Dirksen, RT; Hidalgo, C; and Hamilton, SL. "Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in RyR1." J. Biol. Chem. 2006; 281: 40354-40368.
2005 Aug 1
Kimura T, Nakamori M, Lueck JD, Pouliquin P, Aoike F, Fujimura H, Dirksen RT, Takahashi MP, Dulhunty AF, Sakoda S. "Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1." Human molecular genetics. 2005 Aug 1; 14(15):2189-200. Epub 2005 Jun 22.
2005 Jul
Avila G, Dirksen RT. "Rapamycin and FK506 reduce skeletal muscle voltage sensor expression and function." Cell calcium. 2005 Jul; 38(1):35-44.
2005
Wang H, Oestreich EA, Maekawa N, Bullard TA, Vikstrom KL, Dirksen RT, Kelley GG, Blaxall BC, Smrcka AV. "Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy." Circulation research. 2005 97(12):1305-13. Epub 2005 Nov 17.
2005
Beutner,G.; Sharma,V.K.; Lin,L.; Ryu,S.Y.; Dirksen,R.T.; Sheu,S.S.;. "Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling". Biochemica Biophysica ACTA. 2005; 1717(1): 1-10. Link
2005
Goonasekera SA, Chen SR, Dirksen RT. "Reconstitution of local Ca2+ signaling between cardiac L-type Ca2+ channels and ryanodine receptors: insights into regulation by FKBP12.6." American journal of physiology. Cell physiology. 2005 289(6):C1476-84. Epub 2005 Jul 27.
2004 Nov
Dirksen RT, Avila G. "Distinct effects on Ca2+ handling caused by malignant hyperthermia and central core disease mutations in RyR1." Biophysical journal. 2004 Nov; 87(5):3193-204. Epub 2004 Sep 03.
2004 Oct
Weiss RG, O'Connell KM, Flucher BE, Allen PD, Grabner M, Dirksen RT. "Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling." American journal of physiology. Cell physiology. 2004 Oct; 287(4):C1094-102. Epub 2004 Jun 16.
2004 Sep 3
Du GG, Avila G, Sharma P, Khanna VK, Dirksen RT, MacLennan DH. "Role of the sequence surrounding predicted transmembrane helix M4 in membrane association and function of the Ca(2+) release channel of skeletal muscle sarcoplasmic reticulum (ryanodine receptor isoform 1)." The Journal of biological chemistry. 2004 Sep 3; 279(36):37566-74. Epub 2004 Jun 28.
2004
Lyfenko,A.D.; Goonasekera,S.A.; Dirksen,R.T.;. "Dynamic alterations in myoplasmic Ca2+ in malignant hyperthermia and central core disease". Biochemical Biophysical Research Communications. 2004; 322(4): 1256-1266. Link
2003 Jul
He X, Liu Y, Sharma V, Dirksen RT, Waugh R, Sheu SS, Min W. "ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes." The American journal of pathology. 2003 Jul; 163(1):243-51.
2003 Jun 20
Avila G, Lee EH, Perez CF, Allen PD, Dirksen RT. "FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes." The Journal of biological chemistry. 2003 Jun 20; 278(25):22600-8. Epub 2003 Apr 17.
2003 Jun
Leuranguer V, Dirksen RT, Beam KG. "Potentiated L-type Ca2+ channels rectify." The Journal of general physiology. 2003 Jun; 121(6):541-50. Epub 2003 May 12.
2003 Apr
Avila G, O'Connell KM, Dirksen RT. "The pore region of the skeletal muscle ryanodine receptor is a primary locus for excitation-contraction uncoupling in central core disease." The Journal of general physiology. 2003 Apr; 121(4):277-86. Epub 2003 Mar 17.
2002 Sep
O'Connell KM, Yamaguchi N, Meissner G, Dirksen RT. "Calmodulin binding to the 3614-3643 region of RyR1 is not essential for excitation-contraction coupling in skeletal myotubes." The Journal of general physiology. 2002 Sep; 120(3):337-47.
2002 Jul
Dirksen RT, Avila G. "Altered ryanodine receptor function in central core disease: leaky or uncoupled Ca(2+) release channels?" Trends in cardiovascular medicine. 2002 Jul; 12(5):189-97.
2002 Feb
Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS. "Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation." Journal of neurochemistry. 2002 Feb; 80(3):531-8.
2002
Papineni RV, O'Connell KM, Zhang H, Dirksen RT, Hamilton SL. "Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1." The Journal of biological chemistry. 2002 277(51):49167-74. Epub 2002 Oct 02.
2002
Dirksen,R.T.;. "Bi-directional coupling between dihydropyridine receptors and ryanodine receptors". Frontiers Bioscience. 2002; 7:d659-70.: d659-d670. Link
2002
Dirksen RT. "Reactive oxygen/nitrogen species and the aged brain: radical impact of ion channel function." Neurobiology of aging. 2002 23(5):837-9; discussion 841-2.
2001 Sep
Avila G, Dirksen RT. "Functional effects of central core disease mutations in the cytoplasmic region of the skeletal muscle ryanodine receptor." The Journal of general physiology. 2001 Sep; 118(3):277-90.
2001 May 25
Avila G, O'Connell KM, Groom LA, Dirksen RT. "Ca2+ release through ryanodine receptors regulates skeletal muscle L-type Ca2+ channel expression." The Journal of biological chemistry. 2001 May 25; 276(21):17732-8. Epub 2001 Jan 22.
2001
Avila,G.; O'Brien,J.J.; Dirksen,R.T.;. "Excitation--contraction uncoupling by a human central core disease mutation in the ryanodine receptor". Proceedings National Academy Sciences United States of America. 2001; 98(7): 4215-4220. Link
2000 Apr
Avila G, Dirksen RT. "Functional impact of the ryanodine receptor on the skeletal muscle L-type Ca(2+) channel." The Journal of general physiology. 2000 Apr; 115(4):467-80.
2000
O'Connell,K.M.; Dirksen,R.T.;. "Prolonged depolarization promotes fast gating kinetics of L-type Ca2+ channels in mouse skeletal myotubes". Journal Physiology. 2000; 529: 647-659. Link
2000
Suda,N.; Dirksen,R.T.; Gonzalez,A.; Beam,K.G.;. "Low serum promotes maturation of excitation-contraction coupling in myotubes". Pflugers Archive. 2000; 439(5): 555-558. Link
1999 Sep
Dirksen RT, Beam KG. "Role of calcium permeation in dihydropyridine receptor function. Insights into channel gating and excitation-contraction coupling." The Journal of general physiology. 1999 Sep; 114(3):393-403.
1999 Jul 30
Grabner M, Dirksen RT, Suda N, Beam KG. "The II-III loop of the skeletal muscle dihydropyridine receptor is responsible for the Bi-directional coupling with the ryanodine receptor." The Journal of biological chemistry. 1999 Jul 30; 274(31):21913-9.
1998
Grabner,M.; Dirksen,R.T.; Beam,K.G.;. "Tagging with green fluorescent protein reveals a distinct subcellular distribution of L-type and non-L-type Ca2+ channels expressed in dysgenic myotubes". Proceedings National Academy Sciences United States of America. 1998; 95(4): 1903-1908. Link
1997 Sep
Dirksen RT, Nakai J, Gonzalez A, Imoto K, Beam KG. "The S5-S6 linker of repeat I is a critical determinant of L-type Ca2+ channel conductance." Biophysical journal. 1997 Sep; 73(3):1402-9.
1996 Jun
Dirksen RT, Beam KG. "Unitary behavior of skeletal, cardiac, and chimeric L-type Ca2+ channels expressed in dysgenic myotubes." The Journal of general physiology. 1996 Jun; 107(6):731-42.
1996 Mar 7
Nakai J, Dirksen RT, Nguyen HT, Pessah IN, Beam KG, Allen PD. "Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor." Nature. 1996 Mar 7; 380(6569):72-5.
1995 Feb
Dirksen RT, Beam KG. "Single calcium channel behavior in native skeletal muscle." The Journal of general physiology. 1995 Feb; 105(2):227-47.
1994
Arreola J, Dirksen RT, Perez-Cornejo P, Piech KM, Sheu SS. "Autonomic modulation of action potential and tension in guinea pig papillary muscles." European journal of pharmacology. 1994 271(2-3):309-17.
1993 Apr
Fujita Y, Mynlieff M, Dirksen RT, Kim MS, Niidome T, Nakai J, Friedrich T, Iwabe N, Miyata T, Furuichi T. "Primary structure and functional expression of the omega-conotoxin-sensitive N-type calcium channel from rabbit brain." Neuron. 1993 Apr; 10(4):585-98.
1993
Mori,Y.; Niidome,T.; Fujita,Y.; Mynlieff,M.; Dirksen,R.T.; Beam,K.G.; Iwabe,N.; Miyata,T.; Furutama,D.; Furuichi,T.;. "Molecular diversity of voltage-dependent calcium channel". Annals New York Academy Sciences. 1993; 707:87-108.: 87-108. Link
1991
Arreola,J.; Dirksen,R.T.; Shieh,R.C.; Williford,D.J.; Sheu,S.S.;. "Ca2+ current and Ca2+ transients under action potential clamp in guinea pig ventricular myocytes". American Journal of Physiology (Cell Physiology). 1991; 261(2 Pt 1): C393-C397. Link
1991
Sheu,S.S.; Sharma,V.K.; Korth,M.; Moscucci,A.; Dirksen,R.T.; Jou,M.J.;. "Receptor-mediated inotropic effect in heart. Role of sodium-calcium exchange". Annals New York Academy Sciences. 1991; 639:398-407.: 398-407. Link
1990 May
Enyeart JJ, Dirksen RT, Sharma VK, Williford DJ, Sheu SS. "Antipsychotic pimozide is a potent Ca2+ channel blocker in heart." Molecular pharmacology. 1990 May; 37(5):752-7.
1990
Dirksen,R.T.; Sheu,S.S.;. "Modulation of ventricular action potential by alpha 1-adrenoceptors and protein kinase C". American Journal of Physiology(Heart Circulation Physiology). 1990; 258(3 Pt 2): H907-H911. Link
1986 Nov 15
Reichman M, Dirksen R, Abood LG, Gala D. "Effects of the affinity ligands 14-beta-chloroacetylnaltrexone and 14-beta-bromoacetamidomorphine on [3H]-dihydromorphine binding sites in rat brain." Biochemical pharmacology. 1986 Nov 15; 35(22):3995-8.

Books

2006
Rosenberg, H; and Dirksen, RT. "Malignant hyperthermia Susceptibility is: GeneReviews at GeneTests.". Medical Genetics Information Resource [database online]. Seattle: University of Washington, 2006. Updated 2010.
2005
Dirksen RT and Avila G. "Pathophysiology of muscle disorders linked to mutations in the skeletal muscle ryanodine receptor.". Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease. XH Wehrens and AR Marks. : Springer, 2005. 229-242